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Spectrochim Acta A Mol Biomol Spectrosc ; 319: 124550, 2024 Oct 15.
Article in English | MEDLINE | ID: mdl-38823240

ABSTRACT

Near-infrared organic fluorescent probes have great need in biological sciences and medicine but most of them are still largely unable to meet demand. In this work, a delicate multipurpose organic fluorescent probe (DPPM-TPA) with aggregation-induced emission performances is designed and prepared by facile method to reflect fluorescence labeling, two-photon imaging, and long-term fluorescent tracking. Specifically, DPPM-TPA NPs was constructed from 4-(diphenylamino)phenylboronic acid and DPPM-Br by classical Suzuki coupling reaction and then coated with F127. Such nanoprobe possessed high stability in diverse medium under ambient temperatures, low cytotoxicity, and brilliant fluorescence performance. More importantly, DPPM-TPA NPs showed excellent two-photon imaging and extraordinary long-term fluorescence tracing capacity to malignant tumor, and it can last up to 9 days. These results indicated that DPPM-TPA NPs is expected to serve as a fluorescent probe for photodiagnostic and providing a new idea for the development of long-term fluorescent tracker.


Subject(s)
Fluorescent Dyes , Fluorescent Dyes/chemistry , Humans , Animals , Neoplasms , Mice , Spectrometry, Fluorescence , Nanoparticles/chemistry , Cell Line, Tumor , Boronic Acids/chemistry
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