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Org Biomol Chem
; 16(16): 3012-3017, 2018 04 25.
Article
in English
| MEDLINE
| ID: mdl-29633771
ABSTRACT
The direct enantioselective amination of nitroolefins has been performed with l-tert-leucine-derived squaramide-scaffold bifunctional phase-transfer catalysts under base-free and water-rich conditions with low catalyst loading (0.5-1 mol%) to provide 2-aminonitroalkanes in good yields (up to 96%) and enantioselectivities (up to 93% ee).