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J Am Chem Soc ; 144(25): 11081-11087, 2022 06 29.
Article in English | MEDLINE | ID: mdl-35709491

ABSTRACT

The recent surge in the applications of deuterated drug candidates has rendered an urgent need for diverse deuterium labeling techniques. Herein, an efficient Rh-catalyzed deuterated Tsuji-Wilkinson decarbonylation of naturally available aldehydes with D2O is developed. In this reaction, D2O not only acts as a deuterated reagent and solvent but also promotes Rh-catalyzed decarbonylation. In addition, decarbonylative strategies for the synthesis of terminal monodeuterated alkenes from α,ß-unsaturated aldehydes are within reach.


Subject(s)
Rhodium , Aldehydes , Alkenes , Catalysis , Deuterium Oxide
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