ABSTRACT
Respiratory syncytial virus (RSV) is a significant viral pathogen that causes respiratory infections in infants, the elderly, and immunocompromised individuals. RSV-related illnesses impose a substantial economic burden worldwide annually. The molecular structure, function, and in vivo interaction mechanisms of RSV have received more comprehensive attention in recent times, and significant progress has been made in developing inhibitors targeting various stages of the RSV replication cycle. These include fusion inhibitors, RSV polymerase inhibitors, and nucleoprotein inhibitors, as well as FDA-approved RSV prophylactic drugs palivizumab and nirsevimab. The research community is hopeful that these developments might provide easier access to knowledge and might spark new ideas for research programs.
Subject(s)
Respiratory Syncytial Virus Infections , Respiratory Syncytial Virus, Human , Humans , Infant , Aged , Antiviral Agents/pharmacology , Antiviral Agents/therapeutic use , Palivizumab/pharmacology , Palivizumab/therapeutic use , Respiratory Syncytial Virus Infections/drug therapy , Respiratory Syncytial Virus Infections/prevention & control , Anti-Retroviral Agents/therapeutic useABSTRACT
Two unexpected chiral organometallic triangles rather than squares from newly designed 90° chiral di-Pt(II) acceptors were obtained through coordination-driven self-assembly. Their structures were well characterized by multinuclear NMR ((1)H and (31)P) and variable-temperature NMR experiments, ESI-TOF-MS, and elemental analysis. The PM6 semiempirical molecular simulation was employed for the interpretation of the formation and stability of such chiral triangles.
Subject(s)
Organoplatinum Compounds/chemistry , Platinum/chemistry , Crystallography, X-Ray , Magnetic Resonance Spectroscopy , Molecular Structure , Nuclear Magnetic Resonance, Biomolecular , StereoisomerismABSTRACT
A simple quinoline-based fluorescent probe, PBQ, which contained a tweezer-like receptor, was successfully developed via one-step synthesis. PBQ exhibited a 40-fold fluorescence enhancement response to Cd(2+) in aqueous solution. PBQ was found to have excellent selectivity for Cd(2+) over many other metal ions (Ba(2+), Mn(2+), Hg(2+), Ni(2+), Ca(2+), Cu(2+), Co(2+), Pb(2+), Mg(2+), Zn(2+), Fe(2+), Fe(3+), Cr(3+), Ag(+), Li(+), Na(+), K(+)). Significantly, its fluorescence intensity was enhanced in a linear fashion with the concentration of Cd(2+). Thus PBQ can be potentially used for the quantification of Cd(2+). Moreover, a series of model compounds were rationally designed and synthesized in order to explore the binding mode of PBQ with Cd(2+).
