In Situ Construction of (NiCo)3Se4 Nanobeads Embedded in N-Doped Carbon 3D Interconnected Networks for Enhanced Sodium Storage.

Transition metal selenides, boasting remarkable specific capacity, have emerged as a promising electrode material. However, the substantial volume fluctuations during sodium ion insertion and extraction result in inadequate cyclic stability and rate performance, impeding their practical utility. Here, we synthesized N-doped carbon three-dimensional (3D) interconnected networks encapsulating (NiCo)3Se4 nanoparticles, denoted as ((NiCo)3Se4/N-C), exhibiting a bead-like structure and carbon confinement through electrospinning and subsequent thermal treatment. The N-doped carbon 3D interconnected networks possess high porosity and ample volume buffering capacity, enhance conductivity, shorten ion diffusion paths, and mitigate mechanical stress induced by volume changes during cycling. The uniformly distributed (NiCo)3Se4 nanoparticles, featuring a stable structure, demonstrate rapid electrochemical kinetics and numerous available active sites. The distinctive structure and composition of the optimized (NiCo)3Se4/N-C material showcase a high specific capacity (656.2 mAh g-1 at 0.1 A g-1) and an outstanding rate capability. A kinetic analysis confirms that (NiCo)3Se4/N-C stimulates the pseudocapacitive Na+ storage mechanism with capacitance contributing up to 89.2% of the total capacity. This unique structure design and doping approach provide new insights into the design of electrode materials for high-performance batteries.

Pathogenicity of a novel bovine adenovirus type 3 with a natural deletion partial fiber gene in BALB/c mice.

Objective: A novel Bovine adenovirus type 3 (BAdV-3) with a natural deletion partial fiber gene was isolated in 2020 and named BO/YB24/17/CH. The objective of this study was to understand the pathogenicity of this virus. Methods: Thiry-two 3-week-old BALB/c mice were divided into three experimental groups and a control group. Mice in the experimental groups were intranasally inoculated with virus, and mice in the control group were inoculated with MDBK cell supernatant. Mice were weighed and clinically examined daily for appearance of any clinical signs. Three infected mice and one control mouse were euthanized at 1, 3, 5, 7, 9, 11, 13, and 15 days after inoculation. Tissue samples were collected for histopathological examination, immunohistochemical staining, and detection of the replication dynamics of virus. Results: All infected mice developed mild clinical signs such as lethargy, weight loss, loss of appetite, and a rough hair coat, and gross lesions were observed as pulmonary punctate hemorrhage, lobular atrophy and splenomegaly. Histopathological examination revealed thickening of alveolar septa and mildly dilated splenic nodules and blurred red-white medullary demarcation in the spleen. Immunohistochemical results further confirmed that the production of the above lesions was due to viral infection. Importantly, unlike previously reported BAdV-3 detection only in the lungs and trachea, this isolate could be detected in multiple organs such as the heart, liver, spleen, kidney, and even blood by virus isolation and titration and real-time PCR methods. Clinical significance: This study provides further insight into the pathogenicity of the fiber region deletion strain BO/YB24/17/CH in BALB/c mice, which provides a reference for the prevention and control of BAdV-3 as well as the development of vaccines.

Concise Total Synthesis of (-)-Quinocarcin Enabled by Catalytic Enantioselective Reductive 1,3-Dipolar Cycloaddition of Secondary Amides.

A concise asymmetric total synthesis of (-)-quinocarcin has been accomplished with high step economy from commercially available starting materials. A catalytic enantioselective reductive 1,3-dipolar cycloaddition reaction of N-heteroaryl secondary amides with reactive dipolarophiles using iridium/copper relay catalysis was developed to prepare the key chiral pyrrolidine intermediate with three stereocenters. This protocol features excellent regio-, exo- and enantioselectivities, broad substrate scope, and good functional group tolerance. The high efficiency was also ensured by a RhIII -catalyzed C-H activation/cyclization and a tandem diastereoselective hydrogenation/cyclization to construct the tetrahydroisoquinoline-pyrrolidine tetracyclic core unit of quinocarcin.

Chemoselective Reactions of Isocyanates with Secondary Amides: One-Pot Construction of 2,3-Dialkyl-Substituted Quinazolinones.

A facile method for the preparation of 2,3-dialkyl-substituted quinazolinones from readily available N-arylamides and commercial isocyanates was developed. This one-pot procedure involves the chemoselective activation of the secondary amide with Tf2O/2-Br-Pyr, the sequential addition of isocyanate, and cyclization. The mild reaction is general for a wide range of substrates and can be run on a gram scale.