Research status of comprehensive utilization of coal-based solid waste (CSW) and key technologies of filling mining in China: A review.

Coal-based solid waste (CSW) is the solid waste generated in the process of coal mining, washing and pyrolysis, which is an important industrial solid waste. The comprehensive utilization of CSW is a key link in the process of clean and efficient utilization of coal, and the use of CSW for coal mine filling mining is an important means of "harmless, resourceful and large-scale" utilization. In order to study the research status of comprehensive utilization of CSW and key technologies of filling mining in China, this paper combs and analyzes the current situation of comprehensive utilization of CSW from three parts, namely, physical and chemical properties of CSW, Industry-related policies, and ways and means of comprehensive utilization. It is found that coal mine filling mining is a green disposal method with relatively reliable technical means, low supervision cost and large-scale disposal of CSW in the comprehensive utilization of CSW in China. Furthermore, an analysis was conducted on the current research status of key technologies in the CSW filling and mining process, including the integration of "mining, selection and filling", adsorption and complexation passivation of heavy metals in CSW, the preparation of CSW collaborative filling materials, and monitoring and control of the whole filling process, etc. Based on the above analysis and research, it was pointed out that there were some problems, namely: (1) large output of CSW and low level of comprehensive utilization; (2) high investment and high cost of CSW filling and mining; and (3) imperfect CSW waste filling mining theory and technology. In response to these issues, prospects have been made from the aspects of policy incentive mechanisms, collaborative utilization of CSW with multi-industry links, and the theory and technology of CSW filling mining. This study provided reference and inspiration for the comprehensive utilization of CSW in the world, and provides guidance for the large-scale promotion and application of CSW filling mining methods.

Efficient seawater desalination in lamellar nanochannel-based boridene filtration membrane.

With the progressively increasing demand for freshwater, the shortage of global freshwater resources has become one of the most serious events that all humans are facing now. The reverse osmosis (RO) technology that achieves freshwater from seawater is a promising strategy. However, current RO membranes suffer from the bottleneck of low efficiency. In this work, we designed a RO membrane based on a novel two-dimensional nanomaterial, boridene, prepared by stacking them into lamellar nanochannels. We employed the molecular dynamics (MD) simulation approach to investigate the desalination performance of the designed boridene lamellar membrane. Our results showed that the water permeability through the boridene membrane increased following the incremental interlayer spacing. In addition, the boridene membrane exhibits high water permeability and ideal salt rejection, featuring water permeability far beyond those obtained from commercial RO membranes with two orders of magnitude enhancement. Further free energy calculations demonstrated that the water molecules are energetically more favorable to transport through the boridene lamellar nanochannels than ions. Therefore, our results highlight that the boridene lamellar nanochannel-based filtration membrane can be utilized as a potential outstanding candidate in RO membranes for future desalination applications.

Analysis of clinical characteristics of severe pertussis in infants and children: a retrospective study.

BACKGROUND: The incidence of pertussis shows an increasing trend in recent years, but some clinicians often lack sufficient understanding of the clinical characteristics and risk factors for severe pertussis, and more effective measures should be taken to reduce the incidence and mortality of pertussis in young infants METHODS: A retrospective study was conducted, and 184 infants and children with pertussis who had been hospitalized in the Department of Pediatrics of Beijing Ditan Hospital affiliated with Capital Medical University from January 2016 to December 2017 were included. Clinical data of the patients were collected and the clinical characteristics were statistically analyzed RESULTS: Among the 184 patients, 41.85% were infants < 3 months of age, and 65.22% of the total patients were not vaccinated against pertussis. There were 22 critically ill children, among whom 4 died, and compared with mild cases, they had a higher proportion of children younger than 3 months of age and infants not vaccinated against pertussis (63.64% vs. 38.89% and 100% vs. 60.49%, respectively); a higher proportion of children with severe pneumonia (100% vs. 0%); higher leukocyte count(× 109/L , 35.80 ± 20.53 vs 19.41 ± 8.59); and a higher proportion of children with severe hyperleukocytosis (18.18% vs. 0%, respectively) (P<0.05) CONCLUSIONS: 1. Infants aged <3 months not vaccinated for pertussis appear more likely to become infected and have more severe disease. 2. Severe pneumonia and hyperleukocytosis are the main mechanisms underlying severe pertussis.

Epidemiological and clinical characteristics of 35 children with COVID-19 in Beijing, China.

IMPORTANCE: Within the coronavirus disease 2019 (COVID-19) global pandemic, more attention is warranted for whether this new infectious disease has unique manifestations in children. OBJECTIVE: To retrospectively determine the epidemiological and clinical characteristics of 35 children with COVID-19 in Beijing, China. METHODS: We collected data for 35 children diagnosed with COVID-19 who were admitted to Beijing Ditan Hospital from January 2020 to June 2020, and analyzed their epidemiological characteristics, clinical manifestations, laboratory examinations, chest imaging findings, treatments, and outcomes. RESULTS: The children comprised 18 boys (51.4%) and 17 girls (48.6%) aged 6 months to 15 years. All patients had clear epidemiological history, with family clusters accounting for 28 cases (80.0%) and clear tracing of exposure to high epidemic areas in the remaining 7 cases (20.0%). Four (11.4%) patients were classified as asymptomatic, 17 (48.6%) as acute upper respiratory infection, and 14 (40.0%) as mild pneumonia, with no severe or critical cases. Clinical manifestations were mild, including fever in 18 (51.4%), cough in 14 (40.0%), and nausea and diarrhea in 7 (20.0%) patients. White blood cell count was mostly normal (26 cases, 74.3%) or decreased (7 cases, 20.0%); lymphocyte percentage was increased in 24 (68.7%); neutrophil percentage was decreased in 25 (71.4%); alanine aminotransferase was increased in 3 (8.6%); and serum potassium was decreased in 4 (11.4%). Time to negative viral nucleic acid testing was 2-42 days (mean: 14.0 ± 9.4 days). Chest imaging examination revealed that 20 patients (57.1%) had different forms of lung inflammation. Treatment was mainly isolation and nutritional support. Eleven patients were treated with interferon atomization inhalation. No patients required oxygen therapy. All 35 children were cured and discharged. Length of hospital stay was 9-54 days (mean: 25.4 ± 13.8 days). During regular follow-up after discharge, 5 children showed positivity again in the viral nucleic acid test and were re-hospitalized for observation and treatment. The mean length of re-hospitalization stay was 10.8 days. INTERPRETATION: Children with COVID-19 mainly become infected within their family, and children of all ages are generally susceptible. The disease in children is mostly mild and the prognosis is good. Nucleic acid tests in some patients become positive again after discharge, suggesting that it is of great significance to carry out centralized isolation medical observations and active nucleic acid tests in close contacts for early detection of patients and routine epidemic prevention and control.

Unique manifestations and risk factors of Jarisch-Herxheimer reaction during treatment of child congenital syphilis.

OBJECTIVES: The objective of this retrospective study was to summarise the clinical manifestations of, and to analyse the incidence and risk factors of, Jarisch-Herxheimer reaction (JHR) during the treatment of children with symptomatic congenital syphilis. METHODS: Clinical data of 60 children with clinically and laboratory diagnosed congenital syphilis, hospitalised in Beijing Ditan Hospital between January 2010 and November 2015, were collected and analysed. RESULTS: A total of 11 patients with congenital syphilis (11/60, 18.3%) developed JHR. JHR occurred in 1-6 hour after the first dose of penicillin. Common clinical manifestations included fever (11/11, 100%), irritability (11/11, 100%), rapid pulse and breathing (11/11, 100%), exacerbation of existing rash (5/11, 45.6%) and chills (3/11, 27.3%). Of the 11 patients who developed JHR, 9 patients (9/11, 81.8%) had bone syphilis, 10 (10/11, 90.9%) had more than three organs affected by syphilis and 10 (10/11, 90.9%) had a high plasma concentration of rapid plasma reagin (RPR) (≥1:256); these percentages were significantly higher than in patients who had not developed JHR (p<0.05), suggesting that the occurrence of JHR was related to bone syphilis, having more than three organs affected by syphilis and a high plasma concentration of RPR. CONCLUSIONS: Clinicians should be familiar with the risk factors for this reaction and its common clinical manifestations.