A model for comprehensive oral biological age score with oral and systemic clinical parameters.

BACKGROUND: Biological age reflects the functional status of an individual. The purpose of the study was to develop a model for estimating oral biological age with oral and systemic parameters. METHODS: A total of 248 subjects who had a routine health check were assessed with oral and general clinical examination. Chi-square test was performed to screen oral clinical candidate indicators. General parameters were analyzed by Pearson correlation coefficient and principal component analysis to develop a general biological age score. A final comprehensive model of oral biological age score was established by combining oral and general biological age score. RESULTS: A total of eight oral indicators (mucosal blood blister, mucosal dryness, impacted tooth, missing teeth, residual crowns, dental calculus, gingival hyperemia, and gingival recession) and 10 general clinical indicators (triglyceride, creatinine, blood urea nitrogen, glucose, total cholesterol, mean erythrocyte hemoglobin concentration, mean erythrocyte hemoglobin, uric acid, body weight, and systolic blood pressure) were selected for oral and general biological age score, respectively (r > 0.25, P < 0.05). A model of comprehensive oral biological age score was then formed by principal component analysis: 0.046 triglyceride + 0.010 creatinine + 0.141 blood urea nitrogen + 0.048 glucose + 0.068 total cholesterol + 0.014 mean erythrocyte hemoglobin concentration + 0.082 mean erythrocyte hemoglobin + 0.001 uric acid + 0.020 body weight + 0.005 systolic blood pressure + 0.037 oral biological age score -10.908. The score was increased accordingly with CA. CONCLUSION: Oral biological age can be easily estimated clinically by the model of comprehensive oral biological age score using oral and systemic clinical parameters by general practitioners.

[Simulation on area threshold of urban building land based on water environmental response in watersheds.] / 基于流域水环境响应的城市建设用地面积阈值模拟.

Urban sprawl has impacted increasingly on water environment quality in watersheds. Based on water environmental response, the simulation and prediction of expanding threshold of urban building land could provide an alternative reference for urban construction planning. Taking three watersheds (i.e., Yundang Lake at complete urbanization phase, Maluan Bay at peri-urbanization phase and Xinglin Bay at early urbanization phase) with 2009-2012 observation data as example, we calculated the upper limit of TN and TP capacity in three watersheds and identified the threshold value of urban building land in watersheds using the regional nutrient management (ReNuMa) model, and also predicted the water environmental effects associated with the changes of urban landscape pattern. Results indicated that the upper limit value of TN was 12900, 42800 and 43120 kg, while that of TP was 340, 420 and 450 kg for Yundang, Maluan and Xinglin watershed, respectively. In reality, the environment capacity of pollutants in Yundang Lake was not yet satura-ted, and annual pollutant loads in Maluan Bay and Xinglin Bay were close to the upper limit. How-ever, an obvious upward trend of annual TN and TP loads was observed in Xinglin Bay. The annual pollutant load was not beyond the annual upper limit in three watersheds under Scenario 1, while performed oppositely under Scenario 3. Under Scenario 2, the annual pollutant load in Yundang Lake was under-saturation, and the TN and TP in Maluan Bay were over their limits. The area thresholds of urban building land were 1320, 5600 and 4750 hm2 in Yundang Lake, Maluan Bay and Xinglin Bay, respectively. This study could benefit the regulation on urban landscape planning.

[Study on the influence on the content of dehydrocavidine and total alkaloids in Corydalis saxicola by different drying methods].

OBJECTIVE: To evaluate the influence of five different drying methods on the contents of dehydrocavidine, a main active constituent, and total alkaloids in Corydalis saxicola. METHODS: The whole plant samples of C. saxicola were harvested at its florescence stage, and then immediately divided into four parts of root, stem, leaf, and inflorescence. Each part of sample was dried by the following five methods, drying in a sunshine, drying in a shade, oven-drying at 60 degrees C, vacuum-drying at room temperature and frozen vacuum-drying, respectively. Then the contents of dehydrocavidine and total alkaloids were determined by RP-HPLC and ultraviolet spectrophotometry. RESULTS: The contents of dehydrocavidine and total alkaloids in all the four parts of the sample processed by drying in a shade were significantly higher than those in the samples processed by the other four drying mehods. CONCLUSION: Different drying methods could significantly influence the contents of dehydrocavidine and total alkaloids in C. saxicola. The process of drying in a shade for a long time would be the best.