Evaluation of IVIM in the Spinal Cord of Multiple Sclerosis Patients.

PURPOSE: To evaluate the ability of intravoxel incoherent motion (IVIM), a perfusion-weighted imaging technique, to differentiate microcirculation changes in the spinal cord of patients with multiple sclerosis (MS) compared with healthy individuals. METHODS: Fifteen healthy individuals and 15 individuals with MS underwent IVIM magnetic resonance (MR) imaging using a 3 T scanner with 2-D axial gradient recalled echo and 2-D axial diffusion-weighted imaging (DWI) sequences. The MR images underwent segmentation to produce white matter and gray matter regions of interest. IVIM metrics for perfusion fraction, pseudo-diffusion coefficients, water-diffusion coefficients, and signal without diffusion encoding were calculated using DWI data. An unpaired t test was performed on these IVIM metrics to compare imaging of healthy individuals with imaging of individuals with MS. RESULTS: No significant differences between images from healthy individuals and individuals with MS were found for any IVIM metric. The lowest P values calculated (.082 and .055) were in the white matter region of interest perfusion fraction and pseudo-diffusion measurements. The gray matter region of interest had the highest P value. DISCUSSION: The findings in this study are consistent with current perfusion-weighted imaging literature focused on MS in the brain. The gray matter in MS patients in this study showed reduced perfusion compared with healthy individuals. CONCLUSION: IVIM is a promising imaging technique for the evaluation of the spinal cord in MS patients. It has the potential to provide valuable information on microvascular perfusion and diffusion in the spinal cord, which might be related to disease progression and response to treatment.

Progress testing: An educational perspective exploring the rationale for progress testing and its introduction into a Diagnostic Radiography curriculum.

INTRODUCTION: In March 2020, the first diagnostic radiography degree apprenticeship programme in England was launched at the authors' institution. As part of the programme development and design, the programme development team explored and then implemented progress testing into a strand of the programme. The objective of this educational perspective is to scrutinise the literature around the use of progress testing in higher education programmes, namely medicine, to explain how and why this decision was reached. METHODS: The initial search strategy was developed using the electronic databases CINHAL Complete and SCOPUS. Key words included 'progress test' and 'medicine' or 'health' or 'education' or 'higher education'. Eliminating articles that were not relevant, and also identifying and adding additional articles by key authors and experts resulted in thirty-three key articles being considered for review. RESULTS: The thirty-three articles were a mixture of review articles, empirical research, case studies and conference presentations. Five key themes were identified which are discussed in this article; the evolution of progress testing; advantages of progress testing, disadvantages of progress testing, developing a test framework and academic progression and student feedback. DISCUSSION: Progress testing is now well established in pre-registration medical programmes globally. The advantages of progress testing and the use of frequent look rapid remediation appear to be undisputed. Key disadvantages with progress testing were identified as it being an administrative heavy assessment process as well as a perceived bias towards male students undertaking this type of assessment. CONCLUSION: Now this assessment practice is established within medicine, it seems reasonable to explore its use in other areas of healthcare, such as radiography.

The principles and effectiveness of X-ray scatter correction software for diagnostic X-ray imaging: A scoping review.

PURPOSE: An anti-scatter grid is often used in X-ray radiography to reduce the scattered X-rays generated from the patient. However, the presence of a grid means the patient dose subsequently increases. Recently,severalmanufacturers have developedsoftwarethat is capable of correctingfor scattered X-rays withouttheuse ofa conventional grid. This scoping review aims to systematically map the research assessing scattering correction software and to identify any existing knowledge gaps. METHODS: This scoping review involved conducting a systematic search in PubMed, Scopus, and Web of science to reveal studies that were relevant to the research question. Articles published between 01.01.2000 and 31.12.2021 examining X-ray scatter correction software for X-ray imaging were included. A part of the PRISMA model and PICO framework were utilised to establish eligibility criteria. A structured summary table was utilised to extract data from the selected articles. RESULTS: In this scoping review, 20 years of literature in X-ray conventional radiography. 11 articles were included in the data synthesis. The study populations of the included studies were varied: patients, image quality phantoms and anatomical phantoms. The clinical applications of X-ray scatter correction software were found to be limited to specific body parts (cervical spine, chest, shoulder, lumbar spine, hip and pelvis). The scatter correction software appears to be effective in terms of image quality and in reducing the radiation dose. However, the conventional grid still provides a higher image quality. CONCLUSIONS: X-ray scatter correction software can be effective and provides potentialbenefits for some circumstances or clinical scenarios.

Play simulation for children in magnetic resonance imaging.

INTRODUCTION: Magnetic Resonance Imaging (MRI) can be a challenging examination, particularly for children. The aim of this Clinical Perspective is to outline early experiences, based upon a service evaluation (defined as an assessment of how well the intended aims are achieved), of the Playful Magnetic Resonance Imaging Simulator (PMRIS) (Domed, Lyon, France) in reducing the number of children requiring general anaesthetic (GA) in order to undergo Magnetic Resonance Imaging (MRI). METHODS: Baseline data from an audit of children undergoing MRI under GA in 2017 had previously been captured as part of the funding bid for the PMRIS. Estimation of costs associated with anaesthesia were made, then combined with the overall numbers of MRI under GA to estimate projected anaesthetic related cost-savings based on the reported effectiveness of the PMRIS. Once the PMRIS was in place, data were collected for children attending a Play Specialist supervised session. The number and age of children proceeding directly to MRI without requiring a GA was determined. The associated cost benefit was calculated and compared with the projections made in the initial funding bid. RESULTS: Over a 7 month period 36 children, average age 6 years, age range 4 to 11 years, who had initially been triaged for MRI under GA, attended a Play Specialist led session on the PMRIS. Of these, 30, average age 6 years, age range 4 to 11 years proceeded directly to MRI without a GA. Based on the costings used for the initial funding bid, this equates to a gross cost-saving of £9,000 over 7 months. DISCUSSION: This service evaluation shows a positive impact of Play Specialist sessions using the PMRIS with 30 out of 36 children having a successful awake MRI as a result. There are limitations to this evaluation, particularly that whilst all these children had been triaged for MRI under GA it cannot be known how many might have had an awake MRI with different preparation. Nevertheless, according to the local referral pathways these children would otherwise have had MRI under GA. CONCLUSION: This service evaluation has shown that the number of GAs required for children having MRI has reduced for this particular service through the use of the PMRIS, with Play Specialist support, with associated reduction in risk and cost savings.

Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort.

BACKGROUND: Brain iron deposition occurs in dementia. In European ancestry populations, the HFE p.C282Y variant can cause iron overload and hemochromatosis, mostly in homozygous males. OBJECTIVE: To estimate p.C282Y associations with brain MRI features plus incident dementia diagnoses during follow-up in a large community cohort. METHODS: UK Biobank participants with follow-up hospitalization records (mean 10.5 years). MRI in 206 p.C282Y homozygotes versus 23,349 without variants, including T2* measures (lower values indicating more iron). RESULTS: European ancestry participants included 2,890 p.C282Y homozygotes. Male p.C282Y homozygotes had lower T2* measures in areas including the putamen, thalamus, and hippocampus, compared to no HFE mutations. Incident dementia was more common in p.C282Y homozygous men (Hazard Ratio HR = 1.83; 95% CI 1.23 to 2.72, p = 0.003), as was delirium. There were no associations in homozygote women or in heterozygotes. CONCLUSION: Studies are needed of whether early iron reduction prevents or slows related brain pathologies in male HFE p.C282Y homozygotes.

Investigation of changes in bone density and chemical composition associated with bone marrow oedema-type appearances in magnetic resonance images of the equine forelimb.

BACKGROUND: The aetiology of bone marrow oedema-like abnormalities (BMOA) seen on magnetic resonance imaging (MRI) is as yet not fully understood. The current study aimed to investigate the potential of projection radiography and Raman microspectroscopy to provide information regarding the underlying physiological changes associated with BMOA in equine bone samples. METHODS: MRI was used to assess 65 limbs from 43 horses. A subset of 13 limbs provided 25 samples, 8 with BMOA present and 17 as controls; these were examined with projection radiography to assess bone mineral density and Raman spectroscopy to assess bone composition. Statistical analysis was conducted using SPSS, the relationship between BMOA and age was tested using binary logistic regression, other outcome measures via unpaired t-tests. RESULTS: Overall BMOA was found to be associated with locally increased bone density (p = 0.011), suggesting increased bone formation; however, no measurable changes relating to bone remodelling were found, and there were no detectable changes in the chemical composition of bone. CONCLUSIONS: BMOA is associated with locally increased bone density, without an associated change in the chemical composition of bone, suggesting this is not linked to BMOA. The presence of increased bone density associated with BMOA does appear to suggest that an increased amount of bone formation is occurring in these regions, but as Raman microspectroscopy data do not demonstrate any significant changes in bone chemical composition associated with BMOA, it would appear that the increased bone volume is due to a greater amount of bone being formed rather than an imbalance in relation to bone remodelling. The study provides a proof of principle for the use of Raman microspectroscopy and projection radiography in in vitro studies of BMOA.