1.
Contact Dermatitis
; 32(2): 78-82, 1995 Feb.
Article
in English
| MEDLINE
| ID: mdl-7758325
ABSTRACT
Between 1964 and 1994, at least 52 patients with cutaneous adverse effects of vitamin K have been described in the European and North American literature. A review of the details of these patients is given and 2 new cases reported. Adverse effects are seen not only in patients with liver-function disturbances but also in patients without liver diseases, and occur mostly after intramuscular or subcutaneous administration of vitamin K1, independent of the total dose. Patch and intracutaneous tests often give positive reactions. The mechanism of action is probably in many patients a delayed-type hypersensitivity reaction.
Subject(s)
Dermatitis, Contact/etiology , Erythema/etiology , Vitamin K/adverse effects , Adolescent , Adult , Aged , Child , Dermatitis, Allergic Contact/etiology , Europe , Female , Humans , Injections , Intradermal Tests , Liver Diseases/complications , Male , Middle Aged , Patch Tests , United States , Vitamin K/administration & dosage , Vitamin K/chemistry , Vitamin K 1/adverse effects
2.
Histopathology
; 23(2): 191-3, 1993 Aug.
Article
in English
| MEDLINE
| ID: mdl-8406394