A cryogenic torsion balance using a liquid-cryogen free, ultra-low vibration cryostat.

We describe a liquid-cryogen free cryostat with ultra-low vibration levels, which allows for continuous operation of a torsion balance at cryogenic temperatures. The apparatus uses a commercially available two-stage pulse-tube cooler and passive vibration isolation. The torsion balance exhibits torque noise levels lower than room temperature thermal noise by a factor of about four in the frequency range of 3-10 mHz, limited by residual seismic motion and by radiative heating of the pendulum body. In addition to lowering thermal noise below room-temperature limits, the low-temperature environment enables novel torsion balance experiments. Currently, the maximum duration of a continuous measurement run is limited by accumulation of cryogenic surface contamination on the optical elements inside the cryostat.

New Test of the Gravitational 1/r

We tested the gravitational 1/r^{2} law using a stationary torsion-balance detector and a rotating attractor containing test bodies with both 18-fold and 120-fold azimuthal symmetries that simultaneously tests the 1/r^{2} law at two different length scales. We took data at detector-attractor separations between 52 µm and 3.0 mm. Newtonian gravity gave an excellent fit to our data, limiting with 95% confidence any gravitational-strength Yukawa interactions to ranges <38.6 µm.

Constraints on Axionlike Dark Matter with Masses Down to 10

We analyzed a 6.7-yr span of data from a rotating torsion-pendulum containing ≈10^{23} polarized electrons to search for the "wind" arising from ultralight, axionlike dark matter with masses between 10^{-23} and 10^{-18} eV/c^{2}. Over much of this range we set a 95% confidence limit F_{a}/C_{e}>2×10^{15} eV on the axionlike decay constant.

Experimental upper bound and theoretical expectations for parity-violating neutron spin rotation in 4He.

Neutron spin rotation is expected from quark-quark weak interactions in the standard model, which induce weak interactions among nucleons that violate parity. We present the results from an experiment searching for the effect of parity violation via the spin rotation of polarized neutrons in a liquid 4He medium. The value for the neutron spin rotation angle per unit length in 4He, d ϕ / d z = [ + 2.1 ± 8.3 (stat.) - 0.2 + 2.9 (sys.) ] × 10 - 7 rad/m, is consistent with zero. The result agrees with the best current theoretical estimates of the size of nucleon-nucleon weak amplitudes from other experiments and with the expectations from recent theoretical approaches to weak nucleon-nucleon interactions. In this paper we review the theoretical status of parity violation in the n → + 4He system and discuss details of the data analysis leading to the quoted result. Analysis tools are presented that quantify systematic uncertainties in this measurement and that are expected to be essential for future measurements.

Erratum: Reduced Limit on the Permanent Electric Dipole Moment of

This corrects the article DOI: 10.1103/PhysRevLett.116.161601.

Reduced Limit on the Permanent Electric Dipole Moment of

This Letter describes the results of the most recent measurement of the permanent electric dipole moment (EDM) of neutral ^{199}Hg atoms. Fused silica vapor cells containing enriched ^{199}Hg are arranged in a stack in a common magnetic field. Optical pumping is used to spin polarize the atoms orthogonal to the applied magnetic field, and the Faraday rotation of near-resonant light is observed to determine an electric-field-induced perturbation to the Larmor precession frequency. Our results for this frequency shift are consistent with zero; we find the corresponding ^{199}Hg EDM d_{Hg}=(-2.20±2.75_{stat}±1.48_{syst})×10^{-30}e cm. We use this result to place a new upper limit on the ^{199}Hg EDM |d_{Hg}|<7.4×10^{-30}e cm (95% C.L.), improving our previous limit by a factor of 4. We also discuss the implications of this result for various CP-violating observables as they relate to theories of physics beyond the standard model.

Short-Range, Spin-Dependent Interactions of Electrons: A Probe for Exotic Pseudo-Goldstone Bosons.

We used a torsion pendulum and rotating attractor with 20-pole electron-spin distributions to probe dipole-dipole interactions mediated by exotic pseudo-Goldstone bosons with m(b)c(2)≤500 µeV and coupling strengths up to 14 orders of magnitude weaker than electromagnetism. This corresponds to symmetry-breaking scales F≤70 TeV, the highest reached in any laboratory experiment. We used an attractor with a 20-pole unpolarized mass distribution to improve laboratory bounds on CP-violating monopole-dipole forces with 1.5 µeV

A slow neutron polarimeter for the measurement of parity-odd neutron rotary power.

We present the design, description, calibration procedure, and an analysis of systematic effects for an apparatus designed to measure the rotation of the plane of polarization of a transversely polarized slow neutron beam as it passes through unpolarized matter. This device is the neutron optical equivalent of a crossed polarizer/analyzer pair familiar from light optics. This apparatus has been used to search for parity violation in the interaction of polarized slow neutrons in matter. Given the brightness of existing slow neutron sources, this apparatus is capable of measuring a neutron rotary power of dϕ/dz = 1 × 10(-7) rad/m.

Limits on exotic long-range spin-spin interactions of electrons.

We surrounded a rotating torsion pendulum containing 9.8×10(22) polarized electrons by 2 or 4 stationary sources, each with a net spin of 6.0×10(24) polarized electrons. Multiple source configurations gave sensitivity to hypothetical dipole-dipole, spin-dot-spin, and spin-cross-spin exchange interactions mediated by bosons with masses up to 20 µeV. For bosons with masses ≤0.1 µeV our null results for the dipole-dipole, spin-dot-spin, and spin-cross-spin forces imply 1σ upper limits on (g(P)(e))(2)/(hc), (g(A)(e))(2)/(hc) and (g(V)(e)g(A)(e))/(hc) of 2.2×10(-16), 3.8×10(-40), and 1.2×10(-28), respectively. We also constrain, for the first time, any possible linear combination of static spin-spin interactions. In this case our upper limits relax to 5.6×10(-16), 9.8×10(-40), and 1.2×10(-28), respectively.

Measurement of linear stark interference in 199Hg.

We present measurements of Stark interference in the (61)S(0)→6(3)P(1) transition in (199)Hg, a process whereby a static electric field E mixes magnetic dipole and electric quadrupole couplings into an electric dipole transition, leading to E-linear energy shifts similar to those produced by a permanent atomic electric dipole moment (EDM). The measured interference amplitude, a(SI) = (a(M1) + a(E2)) = (5.8 ± 1.5) × 10(-9) (kV / cm)(-1), agrees with relativistic, many-body predictions and confirms that earlier central-field estimates are a factor of 10 too large. More importantly, this study validates the capability of the (199)Hg EDM search apparatus to resolve nontrivial, controlled, and sub-nHz Larmor frequency shifts with EDM-like characteristics.

Improved constraints on an axion-mediated force.

Low mass pseudoscalars, such as the axion, can mediate macroscopic parity and time-reversal symmetry-violating forces. We searched for such a force between polarized electrons and unpolarized atoms using a novel, magnetically unshielded torsion pendulum. We improved the laboratory bounds on this force by more than 10 orders of magnitude for pseudoscalars heavier than 1 meV and have constrained this force over a broad range of astrophysically interesting masses (10 µeV to 10 meV).

Improved limit on the permanent electric dipole moment of 199Hg.

We report the results of a new experimental search for a permanent electric dipole moment of 199Hg utilizing a stack of four vapor cells. We find d(199Hg)=(0.49+/-1.29_{stat}+/-0.76_{syst})x10;{-29} e cm, and interpret this as a new upper bound, |d(199Hg)|<3.1x10;{-29} e cm (95% C.L.). This result improves our previous 199Hg limit by a factor of 7, and can be used to set new constraints on CP violation in physics beyond the standard model.

Differential impact of Cetuximab, Pertuzumab and Trastuzumab on BT474 and SK-BR-3 breast cancer cell proliferation.

OBJECTIVES: The potential of epidermal growth factor receptor (EGFR)- and Her2-targeted antibodies Cetuximab, Pertuzumab and Trastuzumab, used in combination to inhibit cell proliferation of breast cancer cells in vitro, has not been extensively investigated. It is anticipated that there would be differences between specific erbB receptor co-expression profiles that would affect tumour cell growth. MATERIALS AND METHODS: We have examined the effects of Cetuximab, Pertuzumab and Trastuzumab, applied separately or in combination, on cell proliferation of BT474 and SK-BR-3 breast cancer cell lines. Cell cycle progression of BT474 and SK-BR-3 cells was statically and dynamically assessed using flow cytometry. In order to discover a potential influence of differential EGFR co-expression on sensitivity to antibody treatment, EGFR was down-regulated by siRNA in SK-BR-3. An annexinV/propidium iodide assay was used to identify potential induction of apoptosis. RESULTS: Treatment with Pertuzumab and Trastuzumab, both targeted to Her2, resulted in a reduced fraction of proliferating cells, prolongation of G(1) phase and a great increase in quiescent BT474 cells. Cetuximab had no additional contribution to the effect of either Pertuzumab or Trastuzumab when administered simultaneously. Treatment with the antibodies did not induce an appreciable amount of apoptosis in either BT474 or SK-BR-3 cells. In contrast to SK-BR-3, the BT474 cell line appears to be more sensitive to antibody treatment due to low EGFR content besides Her2 overexpression. CONCLUSION: The extent of decelerated or blocked cell proliferation after antibody treatment that is targeted to EGFR and to Her2 depends both on EGFR and Her2 co-expression and on antibody combination used in the treatment setting. Cetuximab did not enhance any inhibitory effect of Trastuzumab or Pertuzumab, most probably due to the dominant overexpression of Her2. Cell susceptibility to Trastuzumab/Pertuzumab, both targeted to Her2, was defined by the ratio of EGFR/Her2 co-expression.

Particle-physics implications of a recent test of the gravitational inverse-square law.

We use data from our recent search for violations of the gravitational inverse-square law to constrain dilaton, radion, and chameleon exchange forces as well as arbitrary vector or scalar Yukawa interactions. We test the interpretation of the PVLAS Collaboration effect and a conjectured "fat-graviton" scenario and constrain the gamma_{5} couplings of pseuodscalar bosons and arbitrary power-law interactions.

Tests of the gravitational inverse-square law below the dark-energy length scale.

We conducted three torsion-balance experiments to test the gravitational inverse-square law at separations between 9.53 mm and 55 microm, probing distances less than the dark-energy length scale lambda(d)=[4 -root](variant Planck's over 2pic/rho(d) approximately 85 microm. We find with 95% confidence that the inverse-square law holds (|alpha|

New CP-violation and preferred-frame tests with polarized electrons.

We used a torsion pendulum containing approximately 9 x 10(22) polarized electrons to search for CP-violating interactions between the pendulum's electrons and unpolarized matter in the laboratory's surroundings or the Sun, and to test for preferred-frame effects that would precess the electrons about a direction fixed in inertial space. We find, /g(P)(e)g(S)(N)//(Planck's constant x c) < 1.7 x 10(-36), and /g(A)(e)g(V)(N)//(Planck's constant x c) < 4.8 x 10(-56) for lambda > 1 AU. Our preferred-frame constraints, interpreted in the Kostelecký framework, set an upper limit on the parameter /b(e)/

Measurement of the Parity-Violating Neutron Spin Rotation in (4) He.

In the meson exchange model of weak nucleon-nucleon (NN) interactions, the exchange of virtual mesons between the nucleons is parameterized by a set of weak meson exchange amplitudes. The strengths of these amplitudes from theoretical calculations are not well known, and experimental measurements of parity-violating (PV) observables in different nuclear systems have not constrained their values. Transversely polarized cold neutrons traveling through liquid helium experience a PV spin rotation due to the weak interaction with an angle proportional to a linear combination of these weak meson exchange amplitudes. A measurement of the PV neutron spin rotation in helium (φ PV ( n ,α)) would provide information about the relative strengths of the weak meson exchange amplitudes, and with the longitudinal analyzing power measurement in the p + α system, allow the first comparison between isospin mirror systems in weak NN interaction. An earlier experiment performed at NIST obtained a result consistent with zero: φ PV ( n ,α) = (8.0 ±14(stat) ±2.2(syst)) ×10(-7) rad / m[1]. We describe a modified apparatus using a superfluid helium target to increase statistics and reduce systematic effects in an effort to reach a sensitivity goal of 10(-7) rad/m.

Submillimeter test of the gravitational inverse-square law: a search for "large" extra dimensions.

Motivated by higher-dimensional theories that predict new effects, we tested the gravitational 1/r(2) law at separations ranging down to 218 microm using a 10-fold symmetric torsion pendulum and a rotating 10-fold symmetric attractor. We improved previous short-range constraints by up to a factor of 1000 and find no deviations from Newtonian physics.