Idiopathic Intracranial Hypertension After Abrupt Cessation of Medication: A Case Report of Abrupt Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist Cessation and Review of the Literature.

PURPOSE OF REVIEW: The purpose of this review is two-fold: (1) to discuss a case report of idiopathic intracranial hypertension (IIH) after abrupt cessation of a glucagon-like peptide-1 (GLP-1) receptor agonist with resultant rapid weight gain and (2) to review the literature regarding the potential role of GLP-1 receptor agonists in the treatment of IIH as well as potential pitfalls. RECENT FINDINGS: GLP-1 receptor agonists have become widely used to treat obesity. Obesity is a known risk factor for the development of IIH, though the precise pathophysiology is unclear. GLP-1 receptor agonists may help treat IIH by promoting weight loss, lipolysis of adipose tissue, and potentially decreasing the secretion of CSF, as was seen in rat models. Abrupt cessation of GLP-1 receptor agonists can result in regaining lost weight rapidly. In the case that we present, the patient stopped duraglutide abruptly due to lack of insurance coverage and regained the weight she had lost within a month. She subsequently developed IIH. GLP-1 receptor agonists have the potential to help treat IIH; however, this class of medication needs to be used carefully, as cessation of the medication and resultant rapid weight gain can result in IIH.

Crossmodal encoding of motor sequence memories.

In this study, we tested the hypothesis that exposure to specific auditory sequences could lead to the crossmodal induction of new motor memories. Twenty young, healthy participants memorized a melody without moving. Each tone in the memorized melody had previously been associated with a particular finger movement. For ten of the participants, the contour of the melody memorized was congruent to a subsequently performed, but never practiced, finger movement sequence (C group, n = 10). For the other ten participants, the melody memorized was incongruent to the subsequent finger movement sequence (InC group, n = 10). Results showed faster performance of the movement sequence in the C group than in the InC group. This difference in motor performance was most pronounced 6 h after melody learning and then dissipated over 30 days. These results provide evidence of a specific, crossmodal encoding of a movement sequence representation through an auditory sequence with the effect on motor performance lasting for several hours. The findings of this study are significant, as the formation of new motor memories through exposure to auditory stimuli may be useful in rehabilitation settings where the initial encoding of motor memories through physical training is disrupted.