1.
Bioorg Med Chem
; 15(9): 3161-70, 2007 May 01.
Article
in English
| MEDLINE
| ID: mdl-17350267
ABSTRACT
Four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine were synthesized by a stereocontrolled synthetic procedure and evaluated as mGluRs ligands. The (2S,1'R,2'S,3'R)-isomer (PPCG-2) showed to be a group III mGluRs selective ligand endowed with a moderate potency as mGluR4/mGluR6 agonist.