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Br J Haematol ; 132(6): 788-90, 2006 Mar.
Article in English | MEDLINE | ID: mdl-16487181

ABSTRACT

Splenectomy predisposes for invasive pneumococcal disease. We investigated the immune response of splenectomised hereditary spherocytosis (HS) patients upon sequential pneumococcal vaccination. Thirty-nine HS-patients (2- to 18-year-old) had undergone near-total or total splenectomy. All received one dose of 7-valent pneumococcal conjugate vaccine (PCV-7) and 23-valent-pneumococcal-polysaccharide vaccine (PPV-23) 2 months apart. Pneumococcal antibodies against serotypes 5/6B/7/14/18C/19F/23F and immunoglobulin serum concentrations were determined before PCV-7 and 4 weeks after PPV-23. Significant rises in antibody geometric mean concentrations were observed after PCV-7 except for serotypes 5 and 7, which increased after PPV-23. We found no impact of the mode of splenectomy.


Subject(s)
Pneumococcal Infections/prevention & control , Pneumococcal Vaccines/immunology , Spherocytosis, Hereditary/immunology , Splenectomy/adverse effects , Adolescent , Antibodies, Bacterial/analysis , Child , Child, Preschool , Female , Humans , Immunoglobulin A/blood , Immunoglobulin G/blood , Male , Pneumococcal Infections/immunology , Pneumococcal Vaccines/blood , Prospective Studies , Serotyping/methods , Spherocytosis, Hereditary/blood , Spherocytosis, Hereditary/surgery , Splenectomy/methods , Vaccines, Conjugate/immunology
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