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Scand Cardiovasc J ; 54(5): 300-305, 2020 Oct.
Article in English | MEDLINE | ID: mdl-32274953

ABSTRACT

Objective: Congenitally corrected and surgical atrial redirected transposition of the great arteries (TGA) represents states where the morphological right ventricle serves as a systemic ventricle (S-RV). The S-RV is prone to failure, but data on medical treatment on this problem is limited. The purpose of this study was to evaluate the survival in adults with S-RV, with or without heart failure treatment. Design: The SWEDCON registry was used to collect data. All adults with S-RV and minimum follow-up of 1 year were included retrospectively. Medical treatment was defined as taking beta-blockers and/or ACE inhibitors and/or ARBs for more than 50% of the time. Results: We identified 343 patients with S-RV (median age: 21 years). Surgical atrial redirected TGA was present in 58% and congenitally corrected TGA in 42% of patients. The medically treated group (n = 126) had higher rates of impaired S-RV function, use of diuretics, pacemaker and higher NYHA functional class at baseline compared to controls. The proportion of patients with impaired functional class did not change over time in the medically treated group, but increased in controls (21% vs. 30%, p = .015). In Kaplan-Meier analysis, the mean follow-up was 10.3 years, no difference in survival was seen between the groups. Conclusions: Medical treatment may be beneficial in patients with S-RV and impaired functional class and appears to be safe in the long term. The treatment group had equal survival to controls, despite worse baseline characteristics, which might be a result of slower progression of disease in this group.


Subject(s)
Arterial Switch Operation , Cardiovascular Agents/therapeutic use , Congenitally Corrected Transposition of the Great Arteries/surgery , Heart Failure/drug therapy , Ventricular Dysfunction, Right/drug therapy , Ventricular Function, Right/drug effects , Adrenergic beta-Antagonists/therapeutic use , Adult , Angiotensin Receptor Antagonists/therapeutic use , Angiotensin-Converting Enzyme Inhibitors/therapeutic use , Arterial Switch Operation/adverse effects , Arterial Switch Operation/mortality , Cardiovascular Agents/adverse effects , Congenitally Corrected Transposition of the Great Arteries/mortality , Congenitally Corrected Transposition of the Great Arteries/physiopathology , Female , Heart Failure/etiology , Heart Failure/mortality , Heart Failure/physiopathology , Humans , Male , Registries , Retrospective Studies , Sweden , Time Factors , Treatment Outcome , Ventricular Dysfunction, Right/etiology , Ventricular Dysfunction, Right/mortality , Ventricular Dysfunction, Right/physiopathology , Young Adult
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