Genetic control of experience-dependent plasticity in the visual cortex.

Depriving one eye of visual experience during a sensitive period of development results in a shift in ocular dominance (OD) in the primary visual cortex (V1). To assess the heritability of this form of cortical plasticity and identify the responsible gene loci, we studied the influence of monocular deprivation on OD in a large number of recombinant inbred mouse strains derived from mixed C57BL/6J and DBA/2J backgrounds (BXD). The strength of imaged intrinsic signal responses in V1 to visual stimuli was strongly heritable as were various elements of OD plasticity. This has important implications for the use of mice of mixed genetic backgrounds for studying OD plasticity. C57BL/6J showed the most significant shift in OD, while some BXD strains did not show any shift at all. Interestingly, the increase in undeprived ipsilateral eye responses was not correlated to the decrease in deprived contralateral eye responses, suggesting that the size of these components of OD plasticity are not genetically controlled by only a single mechanism. We identified a quantitative trait locus regulating the change in response to the deprived eye. The locus encompasses 13 genes, two of which--Stch and Nrip1--contain missense polymorphisms. The expression levels of Stch and to a lesser extent Nrip1 in whole brain correlate with the trait identifying them as novel candidate plasticity genes.

Dynamics of the batch minority game with inhomogeneous decision noise.

We study the dynamics of a version of the batch minority game, with random external information and with different types of inhomogeneous decision noise (additive and multiplicative), using generating functional techniques à la De Dominicis. The control parameters in this model are the ratio alpha=p/N of the number p of possible values for the external information over the number N of trading agents, and the statistical properties of the agents' decision noise parameters. The presence of decision noise is found to have the general effect of damping macroscopic oscillations, which explains why in certain parameter regions it can effectively reduce the market volatility, as observed in earlier studies. In the limit N-->infinity we (i) solve the first few time steps of the dynamics (for any alpha), (ii) calculate the location alpha(c) of the phase transition (signaling the onset of anomalous response), and (iii) solve the statics for alpha>alpha(c). We find that alpha(c) is not sensitive to additive decision noise, but we arrive at nontrivial phase diagrams in the case of multiplicative noise. Our theoretical results find excellent confirmation in numerical simulations.

Generating functional analysis of the dynamics of the batch minority game with random external information.

We study the dynamics of the batch minority game, with random external information, using generating functional techniques introduced by De Dominicis. The relevant control parameter in this model is the ratio alpha=p/N of the number p of possible values for the external information over the number N of trading agents. In the limit N-->infinity we calculate the location alphac of the phase transition (signaling the onset of anomalous response), and solve the statics for alpha>alphac exactly. The temporal correlations in global market fluctuations turn out not to decay to zero for infinitely widely separated times. For alpha0 we analyze our equations in leading order in alpha, and find asymptotic solutions with diverging volatility sigma=O(alpha(-1/2)) (as regularly observed in simulations), but also asymptotic solutions with vanishing volatility sigma=O(alpha(1/2)). The former, however, are shown to emerge only if the agents' initial strategy valuations are below a specific critical value.