ABSTRACT
Leiomyomatosis peritonealis disseminata is a rare disease characterised by the occurrence of multiple smooth muscle cells building up tumour nodules within the peritoneal cavity. Approximately 50 cases of this disease have been reported in the world literature. To our knowledge, this is the first case reporting the recurrence of leiomyomatosis peritonealis disseminata during combined hormone replacement therapy after hysterectomy and bilateral salpingo-oophorectomy and six laparotomies because of recurrence of the disease.
Subject(s)
Estrogen Replacement Therapy , Fallopian Tubes/surgery , Hysterectomy , Leiomyomatosis/diagnosis , Ovariectomy , Peritoneal Neoplasms/diagnosis , Abdominal Pain , Diagnosis, Differential , Female , Humans , Leiomyomatosis/pathology , Leiomyomatosis/surgery , Middle Aged , Peritoneal Neoplasms/pathology , Peritoneal Neoplasms/surgery , RecurrenceABSTRACT
Breast cancer in men is a rare cancer manifestation, accounting for less then 1% of all breast cancers in both genders. The incidence in Germany during the last years has been approximately 1.0 per year/100,000. In the US, only 0.2% of all malignancies in men. Predisposing risk factors seem to include radiation exposure, hereditary factors, estrogen administration, and diseases associated with hyperestrogenism, such as cirrhosis of the liver or genetic syndromes (i.e. Klinefelter disease). The incidence of male breast cancer is increased in families with a number of first degree relatives affected with breast or prostate cancer. An increased risk of male breast cancer has been reported in families with a mutation of the breast cancer susceptibility gene BRCA-2. For a period of decades, prognosis of breast cancer in males was thought to be worse than that of female patients. Data and cases being published demonstrate that prognosis and strategies of treatment in male breast cancer do not differ from those in females. The cases presented clearly demonstrate that diagnostic work-up, staging procedures and treatment options for primary treatment and advanced stages are identical compared to the recommendation for female breast cancer.
Subject(s)
Breast Neoplasms, Male/therapy , Aged , Antineoplastic Agents/therapeutic use , Axilla , Biopsy, Needle , Breast Neoplasms, Male/diagnosis , Breast Neoplasms, Male/genetics , Breast Neoplasms, Male/pathology , Humans , Lymph Node Excision , Lymph Nodes/pathology , Male , Mammography , Middle Aged , Neck , Neoplasm Metastasis , Neoplasm Recurrence, Local , Neoplasm Staging , Radiography, Thoracic , Remission Induction , Surgical Procedures, Operative , Tomography, X-Ray Computed , UltrasonographyABSTRACT
OBJECTIVE: To report a case of lymphangioma of the ovary after radiation due to Wilms' tumor in the childhood. PATIENT: A 19-year-old nulliparous female. INTERVENTIONS: The vaginal ultrasound showed the left ovary enlarged to 4.4 cm x 2.9 cm x 4.5 cm in size including a 3.5 cm x 2.6 cm x 3.2 cm measuring cystic solid tumor without hypervascularity. For exclusion of a malignant tumor, a laparoscopy for excision of the tumor and deep incision of the left ovary with a bipolar needle was performed to exclude deeper tumor of stromal origin. The histological examination of the tissue showed a lymphangioma beside normal ovarian tissue. CONCLUSION: To our knowledge, this is the first report of lymphangioma of the ovary after radiation due to Wilms' tumor in the childhood. The impact of this finding on the patient's fertility remains unclear. As in other organs exposed to radiation, lymphangioma can also occur in the ovary. Careful follow up should be considered to this patients, because malignant transformation can not be excluded.
