Tracking the misallocation and reallocation of spatial attention towards auditory stimuli.

Completely ignoring a salient distractor presented concurrently with a target is difficult and sometimes attention is involuntarily attracted to the distractor's location (attentional capture). Employing the N2ac component as a marker of attention allocation towards sounds, in this study we investigate the spatio-temporal dynamics of auditory attention across two experiments. Human participants (male and female) performed an auditory search task, where the target was accompanied by a distractor in 2/3rd of the trials. For a distractor more salient than target (Exp. 1), we observe not only a distractor N2ac (indicating attentional capture), but the full chain of attentional dynamics implied by the notion of attentional capture, namely: (a) the distractor captures attention before the target is attended, (b) allocation of attention to the target is delayed by distractor presence, and (c) the target is attended after the distractor. Conversely, for a distractor less salient than the target (Exp. 2), although responses were delayed, no attentional capture was observed. Together, these findings reveal two types of spatial-attentional dynamics in the auditory modality (distraction with and without attentional capture).Significance Statement Oftentimes, we find it hard to avoid attending to a salient sound that distracts us from our current tasks. Although, a common everyday experience, little is known about how spatial distraction unfolds at the neural level in the auditory modality. Using electrophysiological markers of attention allocations, we report comprehensive evidence of spatial attentional capture by a salient auditory distractor, indicating that attention is first misallocated to the distractor and only afterwards reallocated towards the target. Similar patterns were observed earlier only in vision and their discovery in the auditory modality indicates towards the existence of domain-general spatial attentional dynamics consistent across sensory modalities. We also demonstrate that only a distractor more salient than the target reliably captures attention.

Interplay Between Systemic Inflammation, Myocardial Injury, and Coronary Microvascular Dysfunction in Rheumatoid Arthritis: Results From the LiiRA Study.

BACKGROUND: Coronary microvascular dysfunction as measured by myocardial flow reserve (MFR) is associated with increased cardiovascular risk in rheumatoid arthritis (RA). The objective of this study was to determine the association between reducing inflammation with MFR and other measures of cardiovascular risk. METHODS AND RESULTS: Patients with RA with active disease about to initiate a tumor necrosis factor inhibitor were enrolled (NCT02714881). All subjects underwent a cardiac perfusion positron emission tomography scan to quantify MFR at baseline before tumor necrosis factor inhibitor initiation, and after tumor necrosis factor inhibitor initiation at 24 weeks. MFR <2.5 in the absence of obstructive coronary artery disease was defined as coronary microvascular dysfunction. Blood samples at baseline and 24 weeks were measured for inflammatory markers (eg, high-sensitivity C-reactive protein [hsCRP], interleukin-1b, and high-sensitivity cardiac troponin T [hs-cTnT]). The primary outcome was mean MFR before and after tumor necrosis factor inhibitor initiation, with Δhs-cTnT as the secondary outcome. Secondary and exploratory analyses included the correlation between ΔhsCRP and other inflammatory markers with MFR and hs-cTnT. We studied 66 subjects, 82% of which were women, mean RA duration 7.4 years. The median atherosclerotic cardiovascular disease risk was 2.5%; 47% had coronary microvascular dysfunction and 23% had detectable hs-cTnT. We observed no change in mean MFR before (2.65) and after treatment (2.64, P=0.6) or hs-cTnT. A correlation was observed between a reduction in hsCRP and interleukin-1b with a reduction in hs-cTnT. CONCLUSIONS: In this RA cohort with low prevalence of cardiovascular risk factors, nearly 50% of subjects had coronary microvascular dysfunction at baseline. A reduction in inflammation was not associated with improved MFR. However, a modest reduction in interleukin-1b and no other inflammatory pathways was correlated with a reduction in subclinical myocardial injury. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02714881.

Toward Sound Localization Testing in Virtual Reality to Aid in the Screening of Auditory Processing Disorders.

Sound localization testing is key for comprehensive hearing evaluations, particularly in cases of suspected auditory processing disorders. However, sound localization is not commonly assessed in clinical practice, likely due to the complexity and size of conventional measurement systems, which require semicircular loudspeaker arrays in large and acoustically treated rooms. To address this issue, we investigated the feasibility of testing sound localization in virtual reality (VR). Previous research has shown that virtualization can lead to an increase in localization blur. To measure these effects, we conducted a study with a group of normal-hearing adults, comparing sound localization performance in different augmented reality and VR scenarios. We started with a conventional loudspeaker-based measurement setup and gradually moved to a virtual audiovisual environment, testing sound localization in each scenario using a within-participant design. The loudspeaker-based experiment yielded results comparable to those reported in the literature, and the results of the virtual localization test provided new insights into localization performance in state-of-the-art VR environments. By comparing localization performance between the loudspeaker-based and virtual conditions, we were able to estimate the increase in localization blur induced by virtualization relative to a conventional test setup. Notably, our study provides the first proxy normative cutoff values for sound localization testing in VR. As an outlook, we discuss the potential of a VR-based sound localization test as a suitable, accessible, and portable alternative to conventional setups and how it could serve as a time- and resource-saving prescreening tool to avoid unnecessarily extensive and complex laboratory testing.

The surprising robustness of visual search against concurrent auditory distraction.

People often complain about distraction by irrelevant sounds that reportedly hamper performance on concurrent visual tasks demanding the allocation of focused attention toward relevant stimuli, such as processing street signs during driving. To study this everyday issue experimentally, we devised a cross-modal distraction paradigm, inspired by a standard visual-distraction paradigm (additional-singleton paradigm) that is highly sensitive to measure interference on the allocation of attention. In a visual-search pop-out task, participants reported whether a salient target (a tilted bar) was present or absent, while a completely irrelevant, but salient auditory distractor accompanied some trials. To our surprise, the results revealed no notable distraction on visual-search performance (controlled for speed-accuracy tradeoffs). Reliable auditory distraction failed to occur even when the distractor was a (highly salient) auditory oddball or was additionally presented with a temporal advantage of 300 ms. However, when the auditory modality was made relevant globally while maintaining its irrelevance to the visual-search task, we finally observed the expected interference effect. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Terms of debate: Consensus definitions to guide the scientific discourse on visual distraction.

Hypothesis-driven research rests on clearly articulated scientific theories. The building blocks for communicating these theories are scientific terms. Obviously, communication - and thus, scientific progress - is hampered if the meaning of these terms varies idiosyncratically across (sub)fields and even across individual researchers within the same subfield. We have formed an international group of experts representing various theoretical stances with the goal to homogenize the use of the terms that are most relevant to fundamental research on visual distraction in visual search. Our discussions revealed striking heterogeneity and we had to invest much time and effort to increase our mutual understanding of each other's use of central terms, which turned out to be strongly related to our respective theoretical positions. We present the outcomes of these discussions in a glossary and provide some context in several essays. Specifically, we explicate how central terms are used in the distraction literature and consensually sharpen their definitions in order to enable communication across theoretical standpoints. Where applicable, we also explain how the respective constructs can be measured. We believe that this novel type of adversarial collaboration can serve as a model for other fields of psychological research that strive to build a solid groundwork for theorizing and communicating by establishing a common language. For the field of visual distraction, the present paper should facilitate communication across theoretical standpoints and may serve as an introduction and reference text for newcomers.

The Distractor Positivity Component and the Inhibition of Distracting Stimuli.

There has been a long-lasting debate about whether salient stimuli, such as uniquely colored objects, have the ability to automatically distract us. To resolve this debate, it has been suggested that salient stimuli do attract attention but that they can be suppressed to prevent distraction. Some research supporting this viewpoint has focused on a newly discovered ERP component called the distractor positivity (PD), which is thought to measure an inhibitory attentional process. This collaborative review summarizes previous research relying on this component with a specific emphasis on how the PD has been used to understand the ability to ignore distracting stimuli. In particular, we outline how the PD component has been used to gain theoretical insights about how search strategy and learning can influence distraction. We also review alternative accounts of the cognitive processes indexed by the PD component. Ultimately, we conclude that the PD component is a useful tool for understanding inhibitory processes related to distraction and may prove to be useful in other areas of study related to cognitive control.

Increased display complexity reveals effects of salience in action control.

In action-control research, typically, stimulus sparse displays are used. This might be one reason why previous theorizing focuses on the (top-down) demands of response selection (e.g., what key to press), while often ignoring (bottom-up) demands of stimulus selection (e.g., what stimulus to attend). However, complex perceptual situations may pose selection demands that make additional, response-unrelated feature dimensions relevant for response selection. The major stimulus characteristic affecting perceptual selection is salience. In research on visual attention, there is a debate about the conditions under which salience becomes effective. We related both debates in two experiments, in which we modulated display set size as well as salience in a stimulus-response binding task. In sum, the data of these experiments (pooled N = 138) demonstrated that salience furthered the integration of stimulus features in displays with many stimuli more than in sparse displays. Our results demonstrate the neglected impact of salience on action-control when going beyond the very simplistic displays common in action-control research. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Target Salience and Search Modes: A Commentary on Theeuwes (2023).

In a healthy scientific community, theories influence each other and promising ideas are embraced by competing theoretical camps. We are therefore pleased that Theeuwes (2023) now agrees with core points of our theoretical position (Liesefeld et al., 2021; Liesefeld & Müller, 2020), most notably, the central role target salience plays for interference by salient distractors and the conditions that facilitate clump scanning. The present commentary traces the development of Theeuwes' theorizing and carves out remaining discrepancies, most notably the conjecture of two qualitatively distinct search modes. Such a dichotomy is embraced by us, but decidedly rejected by Theeuwes. Accordingly, we selectively review some evidence in favor of search modes that appear crucial to the current debate.

Effects of salience are long-lived and stubborn.

Salience is a core determinant of attentional processing. Although information on salience has been shown to dissipate within a few hundred milliseconds, we recently observed massive effects of salience on the delayed recall from visual working memory more than 1,300 ms after stimulus onset. Here, we manipulated presentation duration of the memory display and found that effects of salience, albeit decreasing over time, were still markedly present after 3,000 ms (2,000 ms presentation; Experiment 1). In an attempt to overrule this persistent influence of salience, we made less salient stimuli more relevant (by rewarding their prioritized processing in Experiment 2 or by probing them more often in Experiment 3). Participants were unable to reliably prioritize low-salience stimuli. Thus, our results demonstrate that effects of salience or their repercussions have surprisingly long-lasting effects on cognitive performance that reach even relatively late processing stages and are difficult to overrule by volition. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Myocardial Perfusion PET for the Detection and Reporting of Coronary Microvascular Dysfunction: A JACC: Cardiovascular Imaging Expert Panel Statement.

Angina pectoris and dyspnea in patients with normal or nonobstructive coronary vessels remains a diagnostic challenge. Invasive coronary angiography may identify up to 60% of patients with nonobstructive coronary artery disease (CAD), of whom nearly two-thirds may, in fact, have coronary microvascular dysfunction (CMD) that may account for their symptoms. Positron emission tomography (PET) determined absolute quantitative myocardial blood flow (MBF) at rest and during hyperemic vasodilation with subsequent derivation of myocardial flow reserve (MFR) affords the noninvasive detection and delineation of CMD. Individualized or intensified medical therapies with nitrates, calcium-channel blockers, statins, angiotensin-converting enzyme inhibitors, angiotensin II type 1-receptor blockers, beta-blockers, ivabradine, or ranolazine may improve symptoms, quality of life, and outcome in these patients. Standardized diagnosis and reporting criteria for ischemic symptoms caused by CMD are critical for optimized and individualized treatment decisions in such patients. In this respect, it was proposed by the cardiovascular council leadership of the Society of Nuclear Medicine and Molecular Imaging to convene thoughtful leaders from around the world to serve as an independent expert panel to develop standardized diagnosis, nomenclature and nosology, and cardiac PET reporting criteria for CMD. This consensus document aims to provide an overview of the pathophysiology and clinical evidence of CMD, its invasive and noninvasive assessment, standardization of PET-determined MBFs and MFR into "classical" (predominantly related to hyperemic MBFs) and "endogen" (predominantly related to resting MBF) normal coronary microvascular function or CMD that may be critical for diagnosis of microvascular angina, subsequent patient care, and outcome of clinical CMD trials.

Same same but different: Subtle but consequential differences between two measures to linearly integrate speed and accuracy (LISAS vs. BIS).

Condition-specific speed-accuracy trade-offs (SATs) are a pervasive issue in experimental psychology, because they sometimes render impossible an unambiguous interpretation of experimental effects on either mean response times (mean RT) or percentage of correct responses (PC). For between-participants designs, we have recently validated a measure (Balanced Integration Score, BIS) that integrates standardized mean RT and standardized PC and thereby controls for cross-group variation in SAT. Another related measure (Linear Integrated Speed-Accuracy Score, LISAS) did not fulfill this specific purpose in our previous simulation study. Given the widespread and seemingly interchangeable use of the two measures, we here illustrate the crucial differences between LISAS and BIS related to their respective choice of standardization variance. We also disconfirm the recently articulated hypothesis that the differences in the behavior of the two combined performance measures observed in our previous simulation study were due to our choice of a between-participants design and we demonstrate why a previous attempt to validate BIS (and LISAS) for within-participants designs has failed, pointing out several consequential issues in the respective simulations and analyses. In sum, the present study clarifies the differences between LISAS and BIS, demonstrates that the choice of the variance used for standardization is crucial, provides further guidance on the calculation and use of BIS, and refutes the claim that BIS is not useful for attenuating condition-specific SATs in within-participants designs.

Unintended emotions in the laboratory: Emotions incidentally induced by a standard visual working memory task relate to task performance.

The ability to temporarily hold information in visual working memory (VWM) is among the most crucial and most extensively examined human cognitive functions. Here, we empirically confirm previous speculations (a) that a standard VWM task arouses emotions in participants and (b) that these task-induced emotions are related to VWM performance. In a first qualitative study (N = 19), by adapting a qualitative method of inquiry, the think-aloud technique, we found that the task induced different positive and negative emotions, such as joy and anger, which varied on the inter- as well as on the intraindividual level. The emotional experiences seemed to be tied to the implicit achievement requirement of the VWM task (getting it right vs. wrong). Encouraged by these findings, two quantitative studies (N = 45, and N = 44, respectively) revealed that VWM performance was positively linked to joy and pride, and negatively linked to anger, frustration, and boredom on the inter- and on the intraindividual level. Notably, these emotions were also affected by an experimental manipulation of task difficulty (set size 4 vs. 8). Further, the findings from Study 3 were replicated in a fourth high-powered online study (N = 110). This research is the first to demonstrate that a task designed to measure VWM in itself triggers emotions, specifically achievement emotions, which, in turn, are linked with VWM performance. Our findings suggest that these task-induced emotions should be considered as potential confounding variables in future research on VWM and in cognitive research in general. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Assessment of cerebral glucose metabolism in patients with heart failure by 18F-FDG PET/CT imaging.

BACKGROUND: To evaluate the cerebral metabolism in patients with heart failure (HF). METHODS: One hundred and two HF patients were prospectively enrolled, who underwent gated 99mTc-sestamibi single photon emission computed tomography (SPECT)/CT, cardiac and cerebral 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT. Fifteen healthy volunteers served as controls. Patients were stratified by extent of hibernating myocardium (HM) and left ventricular ejection fraction (LVEF) into 4 groups where Group1: HM < 10% (n = 33); Group2: HM ≥ 10%, LVEF < 25% (n = 34); Group3: HM ≥ 10%, 25% ≤ LVEF ≤ 40% (n = 16) and Group 4: LVEF > 40% (n = 19). The standardized uptake value (SUV) in the whole brain (SUVwhole-brain) and the SUV ratios (SUVR) in 24 cognition-related brain regions were determined. SUVwhole-brain and SUVRs were compared between the 4 patient groups and the healthy controls. RESULTS: SUVwhole-brain (r = 0.245, P = 0.013) and SUVRs in frontal areas, hippocampus, and para-hippocampus (r: 0.213 to 0.308, all P < 0.05) were correlated with HM. SUVwhole-brain differed between four patient groups and the healthy volunteers (P = 0.016) and SUVwhole-brain in Group 1 was lower than that in healthy volunteers (P < 0.05). SUVRs of Group 3 in frontal areas were the highest among four patient subgroups (P < 0.05). CONCLUSIONS: Cerebral metabolism in the whole brain was reduced but maintained in cognition-related frontal areas in HF patients with HM and moderately impaired global left ventricular function.

Preparatory Control Against Distraction Is Not Feature-Based.

Salient-but-irrelevant stimuli (distractors) co-occurring with search targets can capture attention against the observer's will. Recently, evidence has accumulated that preparatory control can prevent this misguidance of spatial attention in predictable situations. However, the underlying mechanisms have remained elusive. Most pertinent theories assume that attention is guided by specific features. This widespread theoretical claim provides several strong predictions with regard to distractor handling that are disconfirmed here: Employing electrophysiological markers of covert attentional dynamics, in three experiments, we show that distractors standing out by a feature that is categorically different from the target consistently captures attention. However, equally salient distractors standing out in a different feature dimension are effectively down-weighted, even if unpredictably swapping their defining feature with the target. This shows that preparing for a distractor's feature is neither necessary nor sufficient for successful avoidance of attentional capture. Rather, capture is prevented by preparing for the distractor's feature dimension.

EEG evidence for enhanced attentional performance during moderate-intensity exercise.

Research on attentional control within real-world contexts has become substantially more feasible and thus frequent over the past decade. However, relatively little is known regarding how these processes may be influenced by common naturalistic behaviors such as engaging in physical activity, which is thought to modulate the availability of neurometabolic resources. Here, we used an event-related potential (ERP) approach to determine whether various intensities of aerobic exercise might affect the concurrent performance of attentional control mechanisms. Participants performed an additional-singleton visual search task across three levels of aerobic activity while seated on a stationary bicycle: at rest, during moderate-intensity exercise, and during vigorous-intensity exercise. In addition to behavioral measures, attentional processing was assessed via lateralized ERPs referencing target selection (PCN) and distractor suppression (PD ) mechanisms. Whereas engaging in exercise resulted in speeded response times overall, moderate-intensity exercise was found to uniquely eliminate the expression of distractor interference by the PCN while also giving rise to an unanticipated distractor-elicited Ppc. These findings demonstrate workload-specific and object-selective influences of aerobic exercise on attentional processing, providing insights not only for approaching attention in real-world contexts but also for understanding how attentional resources are used overall.

#EEGManyLabs: Investigating the replicability of influential EEG experiments.

There is growing awareness across the neuroscience community that the replicability of findings about the relationship between brain activity and cognitive phenomena can be improved by conducting studies with high statistical power that adhere to well-defined and standardised analysis pipelines. Inspired by recent efforts from the psychological sciences, and with the desire to examine some of the foundational findings using electroencephalography (EEG), we have launched #EEGManyLabs, a large-scale international collaborative replication effort. Since its discovery in the early 20th century, EEG has had a profound influence on our understanding of human cognition, but there is limited evidence on the replicability of some of the most highly cited discoveries. After a systematic search and selection process, we have identified 27 of the most influential and continually cited studies in the field. We plan to directly test the replicability of key findings from 20 of these studies in teams of at least three independent laboratories. The design and protocol of each replication effort will be submitted as a Registered Report and peer-reviewed prior to data collection. Prediction markets, open to all EEG researchers, will be used as a forecasting tool to examine which findings the community expects to replicate. This project will update our confidence in some of the most influential EEG findings and generate a large open access database that can be used to inform future research practices. Finally, through this international effort, we hope to create a cultural shift towards inclusive, high-powered multi-laboratory collaborations.