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1.
Dis Colon Rectum ; 60(3): 274-283, 2017 Mar.
Article in English | MEDLINE | ID: mdl-28177989

ABSTRACT

BACKGROUND: Patients with a locally advanced rectal carcinoma benefit from preoperative chemoradiotherapy. MRI is considered the first choice imaging modality after preoperative chemoradiation, although its reliability for restaging is debatable. OBJECTIVE: The purpose of this study was to determine the accuracy of MRI in restaging locally advanced rectal cancer after preoperative chemoradiation. DESIGN: This was a retrospective study. SETTINGS: The study was conducted in a Dutch high-volume rectal cancer center. PATIENTS: A consecutive cohort of 48 patients with locally advanced rectal cancer treated with a curative intent was identified. MAIN OUTCOME MEASURES: Three readers independently evaluated the MRI both for primary staging and for restaging after preoperative chemoradiation and were blinded to results from the other readers as well as histological results. Interobserver variability was determined. Accuracy of the restaging MRI was assessed through the comparison of tumor characteristics on MRI with histopathologic outcomes. RESULTS: T stage was correctly predicted by the 3 readers in 47% to 68% and N stage in 68% to 70%. Overstaging was more common than understaging. Positive predictive values (PPV) among the 3 readers for T0 were 0%, and negative predictive values (NPVs) varied from 84% to 85%. For T1/2, PPVs and NPVs were 50% to 67% and 72% to 90%, and for T3/4 they were 54% to 62% and 33% to 78%. PPVs and NPVs for N0 stage were 81% to 95% and 58% to 73%. Tumor regression grade on MRI did not correspond with histopathologic tumor regression grade; PPVs for good response (tumor regression grade on MRI 1-2) were 48% to 61%, and NPVs were 42% to 58%. Interobserver agreement was fair to moderate for T stage, N stage, and tumor response (κ = 0.20-0.41) and fair to substantial for the relation with the mesorectal fascia (κ = 0.33-0.77). In none of the patients was the surgical plan changed after the restaging MRI. LIMITATIONS: This study was limited by its small sample size and retrospective nature. CONCLUSIONS: MRI has low accuracy for restaging locally advanced rectal cancer after preoperative chemoradiation, and the interobserver variability is significant.


Subject(s)
Chemoradiotherapy, Adjuvant , Magnetic Resonance Imaging , Rectal Neoplasms/pathology , Rectal Neoplasms/therapy , Aged , Combined Modality Therapy , Female , Humans , Male , Middle Aged , Neoplasm Staging , Netherlands , Observer Variation , Rectal Neoplasms/mortality , Retrospective Studies , Sensitivity and Specificity
2.
Clin Imaging ; 33(4): 267-73, 2009.
Article in English | MEDLINE | ID: mdl-19559348

ABSTRACT

PURPOSE: This study aimed to determine the reliability of magnetic resonance imaging (MRI) without luminal contrast medium versus MR enteroclysis for evaluating small bowel pathology, to compare MRI and MRE findings per observer, and to compare these findings with those of an expert reader in order to determine the influence of luminal contrast medium on morphological evaluations. CONCLUSION: The use of luminal contrast medium bowel improves reliability for measuring bowel wall thickness and for the diagnosis and grading of obstruction when evaluating the small bowel.


Subject(s)
Gadolinium DTPA , Image Enhancement/methods , Image Interpretation, Computer-Assisted/methods , Intestinal Diseases/pathology , Intestine, Small/pathology , Magnetic Resonance Imaging/methods , Adult , Aged , Aged, 80 and over , Contrast Media , Female , Humans , Male , Middle Aged , Observer Variation , Reproducibility of Results , Sensitivity and Specificity , Young Adult
3.
Respir Med ; 101(10): 2227-9, 2007 Oct.
Article in English | MEDLINE | ID: mdl-17616383

ABSTRACT

Low-grade bronchus-associated lymphoid tissue (BALT) lymphoma is a rare tumour originating from the marginal zone of lymphoid tissue. It is a subgroup of B-cell extranodal non-Hodgkin's lymphoma with an indolent course. We report a case of this tumour with characteristic histologic feature. The patient had non-specific respiratory complaints. The tumour occluded the right bronchus intermedius. He received radiation therapy alone, resulting in complete remission of the tumour and disappearance of symptoms.


Subject(s)
Bronchial Neoplasms/radiotherapy , Lymphoma, Non-Hodgkin/radiotherapy , Bronchial Neoplasms/diagnosis , Humans , Lymphoma, Non-Hodgkin/diagnosis , Male , Middle Aged , Positron-Emission Tomography , Respiratory Function Tests , Tomography, X-Ray Computed , Treatment Outcome
4.
AJR Am J Roentgenol ; 187(2): 522-31, 2006 Aug.
Article in English | MEDLINE | ID: mdl-16861559

ABSTRACT

OBJECTIVE: MR enteroclysis has been introduced in the workup of small-bowel diseases. The major advantage of this technique over others is the combined visualization of luminal, mural, and extramural abnormalities. In this article we propose an MR enteroclysis protocol, present a stepwise approach for evaluation of these examinations, and discuss the different inflammatory conditions that can be detected. CONCLUSION: MR enteroclysis can be considered the current first-line imaging technique for inflammatory small-bowel disorders.


Subject(s)
Crohn Disease/diagnosis , Magnetic Resonance Imaging , Adult , Aged , Crohn Disease/diagnostic imaging , Female , Humans , Inflammatory Bowel Diseases/diagnosis , Male , Middle Aged , Radiography
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