Surgical Treatment Selection in Adult Class III Patients With Maxillary Transverse Deficiency.

The purpose of this study was to investigate the frequency of three commonly used treatments for skeletal class III malocclusion with maxillary transverse deficiency (MTD) (SCM) patients in East Asian, to find a quantitative method for precise discrepancy evaluation, and to find other potential indicators for treatment selection. A total of 239 adult SCM patients were divided into3 groups according to treatments.Dentofacial features were measured and the initial skeletal discrepancy was evaluated with computer-aided surgical simulation (CASS). Relationship between the degree of skeletal transverse discrepancy (STD) and other dentofacial features were analyzed by Spearman's rank correlation. The STD in East Asian could be quantitatively grouped as: mild (<4 mm), moderate (4-8 mm), and severe (>8 mm). Most patients (81%) could be diagnosed with mild STD, and were treated without surgical expansion. The upper first molars inclination, the required relative movement and the required maxillary movement were correlated to the degree of STD. The conventional orthodontic and orthognathic treatment without surgical expansion is the most frequent choice for East Asian SCM adults. CASS facilitated analysis is useful in an accurate MTD evaluation. Some dentofacial features were closely correlated to STD, and thus were helpful for the treatment selection.

Virtual Surgical Planning Assisted Management for Three-Dimensional Dentomaxillofacial Deformities.

OBJECTIVE: Treatment of 3-dimensional dentomaxillofacial deformities remains a significant clinical challenge. This retrospective study aims to present the modalities of management for complex 3-dimensional dentomaxillofacial deformities with the assistance of virtual surgical planning (VSP) and 3-dimensional printed navigation templates. STUDY DESIGN: Ten patients diagnosed with complex 3-dimensional dentomaxillofacial deformities received treatment of combined orthodontics and orthognathic surgery. Various surgical techniques as well as bone graft and distraction osteogenesis were used under the guidance of VSP and 3-dimensional printed navigation templates according to the characteristics of each patient. Follow-up included clinical examination and studies of spiral computed tomography preoperatively and for an average of 12 months postoperatively. RESULT: The clinical outcomes of patients showed that VSP was successfully transferred to actual surgery in all the 10 patients. Three-dimensional dentomaxillofacial deformities were corrected significantly. Satisfactory profiles and occlusion were achieved. CONCLUSION: The management of 3-dimensional dentomaxillofacial deformities required comprehensive consideration and detailed surgical planning. Virtual surgical planning serves as a reliable assistance in the management of 3-dimensional dentomaxillofacial deformities.

Factors to Consider When Deciding on the Type of Free-Flap Reconstruction of Head and Neck Soft Tissue Defects.

OBJECTIVES: The aim of the study was to evaluate the functional and aesthetic outcomes on donor and recipient sites and to determine the effects of technical factors including flap thickness and vessel diameters measured by ultrasonography as well as the size of the defect and postoperative volume reduction of the flaps measured by magnetic resonance imaging (MRI). METHODS: In patients who had undergone soft tissue reconstructive surgery between March 2013 and March 2016 using 55 anterolateral thigh flaps (ALTFs), 30 radial forearm flaps (RFFs), and 18 latissimus dorsi flaps (LDFs), color Doppler ultrasonography was performed to measure the thickness of the flap at the site of the perforator. Preoperative color Doppler ultrasound examinations of the blood vessel diameters of donor and recipient sites were carried out. RESULTS: 97.1% of flaps showed complete survival and 2.9% complete failure (2 ALTFs and 1 LDF). The difference in flap volume of ALTFs, RFFs, and LDFs between MRI 1 (3-6 weeks) and MRI 2 (6-18 months) was 27.6, 17.9, and 36.1%, respectively. CONCLUSION: Proper selection of the flap is important for the optimization of the aesthetic and functional outcomes. Ultrasound, the surgeon's experience and the extension and nature of the defect play a key role in the selection of the flap.

The effects of combination of gefitinib and cisplatin on tongue squamous cell carcinoma cell lines.

OBJECTIVES: To study the inhibitory effect of combining the gefitinib with cisplatin on tongue squamous cell carcinoma cells. MATERIALS AND METHODS: Two cell lines were used, tca8113 which is a cisplatin-sensitive cell line, and tca8113/CDDP which is a cisplatin-resistant cell line established in Jiamusi University Laboratories. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was performed to calculate the IC 50 values of both drugs using both cell lines. Detection of Ras, Raf and ERK1/2 was done by using western blot technique after exposure to different concentrations of gefitinib and cisplatin. RESULTS: Tca8113/CDDP has shown more resistance to cisplatin than tca8113 and slightly more resistance to gefitinib than tca8113. Combination of the two drugs has shown to be more effective for both cell lines than when each alone even with lower concentrations. CONCLUSIONS: Combination of gefitinib and cisplatin is a better choice than using each drug alone.