ABSTRACT
The anatomical-pathological findings of 15 woolly monkeys were comparable with those described in man with essential benign or malignant hypertension. Kidneys revealed arterio- and arteriolosclerosis or an onion peel-like proliferation, in some cases necrotizing endarteritis. Obesity due to restricted physical activity, unnatural feeding, and psychical and physical stress could have contributed to the development of this condition. Further, high vulnerability of the genus woolly monkey is postulated. Thus, essential hypertension of woolly monkeys appears to be a multifactorial disease.
Subject(s)
Cebidae , Disease Models, Animal , Hypertension/pathology , Animals , Arteries/pathology , Female , Kidney/pathology , MaleSubject(s)
Animal Diseases/pathology , Strepsirhini , Animals , Carcinoma, Hepatocellular/pathology , Carcinoma, Hepatocellular/veterinary , Communicable Diseases/pathology , Communicable Diseases/veterinary , Congenital Abnormalities/pathology , Congenital Abnormalities/veterinary , Funnel Chest/pathology , Funnel Chest/veterinary , Hemosiderosis/pathology , Hemosiderosis/veterinary , Islets of Langerhans/pathology , Lemur , Liver Neoplasms/pathology , Liver Neoplasms/veterinary , Mortality , Pancreatic Diseases/pathology , Pancreatic Diseases/veterinarySubject(s)
Encephalitis/veterinary , Listeriosis/veterinary , Pan troglodytes , Animals , Brain/microbiology , Brain/pathology , Cerebrospinal Fluid/microbiology , Encephalitis/microbiology , Encephalitis/pathology , Female , Listeria monocytogenes/isolation & purification , Listeriosis/microbiology , Listeriosis/pathology , Meninges/pathology , Palatine Tonsil/microbiologyABSTRACT
Latent diabetes was induced in rats by injecting subdiabetogenic doses of streptozotocin. Four months later, the pancreas was examined and morphology, number and size of Langerhans islets were studied and compared with those of control and overt diabetic animals. In latent diabetics and in diabetics, islet surface per unit pancreas surface was significantly lower (p less than 0.01) than in controls. Immunoreactive insulin in beta cells was visualized by the peroxidase reaction and quantitated by densitometry. Assuming insulin in islets of controls equal to 100%, insulin in islets of latent diabetic rats was reduced to 38% (p less than 0.05) and in diabetics to 6% (p less than 0.01). Differences between latent and overt diabetics were not significant. At the same time occurrence of microangiopathy was taken in consideration and the basement membrane thickness of retinal capillaries was measured on electron micrographs by means of an image analyzer. Compared to controls, retinal capillary basement membranes of latent diabetics had increased by 49% (p = 0.01) and of diabetics by 68% (p less than 0.01). Differences between latent diabetics and diabetics were not significant. These observations demonstrate the induction of microangiopathic changes in rats in absence of hyperglycemia and of a genetic prediabetic disposition. Other mechanisms, possibly related to the induced islet abnormality, may be involved in the basement membrane thickening.
Subject(s)
Diabetes Mellitus, Experimental/pathology , Islets of Langerhans/pathology , Retina/pathology , Animals , Basement Membrane/ultrastructure , Blood Glucose/analysis , Body Weight , Insulin/analysis , Islets of Langerhans/ultrastructure , Male , Microscopy, Electron , Rats , Retina/ultrastructureABSTRACT
A 13-day-old lowland gorilla died from a generalized herpesvirus infection shortly after the onset of clinical signs. The pathologic-anatomical findings were compatible with those described for generalized herpes simplex infection in the human neonate. Electron microscopic examination of lung tissue revealed the presence of herpesvirus which was identified with the fluorescent antibody technique as Herpes simplex virus type I. Tests with related sera of the herpes group (varicella, herpesvirus-B) revealed no specific immunoflourescence.
