ABSTRACT
PIP: A portable unit was developed to provide uniform irradiation of the human testes. The device had built-in radiological protection and provided a dosage independent of the subject geometry, uniform to within +or- 5%. Single doses, between 8-600 rad were administered to the testes of human subjects. Observations were made both before and following irradiation. Parameters evaluated included sperm concentration, motility and morphology, seminal fluid volume, plasma and urinary gonadotropin and testosterone levels, urinary estrogens, and comparison of testicular biopsies taken before and after irradiation in the same subject. Dose-response relationships and recovery times were determined for each dose range studied.^ieng
Subject(s)
Radiation Effects , Testis/radiation effects , Adult , Dose-Response Relationship, Radiation , Estrogens/urine , Follicle Stimulating Hormone/blood , Follicle Stimulating Hormone/urine , Humans , Leydig Cells/radiation effects , Luteinizing Hormone/blood , Luteinizing Hormone/urine , Male , Middle Aged , Sertoli Cells/radiation effects , Spermatogenesis/radiation effects , Spermatozoa/radiation effects , Testosterone/blood , Testosterone/urineSubject(s)
Hydroxysteroid Dehydrogenases/analysis , Testis/enzymology , Cyanides , Dimethyl Sulfoxide , Formamides , Histocytochemistry , Humans , Male , Methods , Potassium , Povidone , Tetrazolium SaltsSubject(s)
Androgen Antagonists , Pregnadienes/pharmacology , Spermatozoa/drug effects , Adult , Contraceptive Agents , Cyproterone/pharmacology , Follicle Stimulating Hormone/blood , Follicle Stimulating Hormone/urine , Humans , Leydig Cells/drug effects , Libido/drug effects , Luteinizing Hormone/blood , Luteinizing Hormone/urine , Male , Semen/drug effects , Spermatogenesis/drug effects , Testis/cytology , Testis/drug effects , Testosterone/blood , Testosterone/urineSubject(s)
Sertoli Cells , Testis/cytology , Adult , Biopsy , Chromosomes , Epithelial Cells , Humans , Male , Semen/cytology , SpermatogenesisABSTRACT
Electron micrographs of human testicular capsule reveal large numbers of branching smooth muscle cells coursing through collagenous tissue of the tunica albuginea. These cells have subcellular morphology characteristic of smooth muscle cells, and they associate with one another through areas of close contact. These are the contractile cells responsible for spontaneous contractions of the human testicular capsule-contractions that may be important in transporting nonmotile sperm out of the testis.