1.
Org Lett
; 14(22): 5628-31, 2012 Nov 16.
Article
in English
| MEDLINE
| ID: mdl-23137072
ABSTRACT
Transannular O-heterocyclization is applied as a key step in a total synthesis. This highly stereoselective and metal-free transformation introduces four stereocenters in one step. It was chosen to be the pivotal step in the synthesis of Murisolin and 16,19-cis-Murisolin, two annonaceous acetogenins. The efficiency of this synthesis is further illustrated by a stereodivergent late-stage separation of both synthetic routes.