1.
Science
; 294(5544): 983-4, 2001 Nov 02.
Article
in English
| MEDLINE
| ID: mdl-11691968
Subject(s)
Behavior, Addictive/etiology , Brain/physiology , Memory , Substance-Related Disorders/etiology , Animals , Behavior, Addictive/physiopathology , Behavior, Addictive/psychology , Brain/cytology , Brain Mapping , Cues , Dopamine/metabolism , Humans , Learning , Long-Term Potentiation , Memory/physiology , Motivation , Neural Pathways/physiology , Neurons/cytology , Neurons/physiology , Reward , Substance-Related Disorders/physiopathology , Substance-Related Disorders/psychology , Synapses/physiology
2.
Science
; 293(5536): 1758-9, 2001 Sep 07.
Article
in English
| MEDLINE
| ID: mdl-11546853
Subject(s)
Linguistics , Persons With Hearing Impairments , Sign Language , Adolescent , Adult , Child , Child, Preschool , Documentation , Education of Hearing Disabled , Humans , Infant , Linguistics/methods , Nicaragua , Schools , Space Perception , Students , Video Recording , Vocabulary
3.
Science
; 293(5536): 1746-7, 2001 Sep 07.
Article
in English
| MEDLINE
| ID: mdl-11546846
Subject(s)
Brain/cytology , Brain/embryology , Cell Movement , Telencephalon/embryology , Thalamus/embryology , Animals , Biological Evolution , Brain/anatomy & histology , Haplorhini , Humans , Mice , Neurons/cytology , Neurons/physiology , Organ Specificity , Species Specificity , Telencephalon/cytology , Thalamus/cytology
4.
Science
; 293(5537): 1971-2, 2001 Sep 14.
Article
in English
| MEDLINE
| ID: mdl-11557854
Subject(s)
Brain/physiology , Emotions , Judgment , Morals , Brain Mapping , Humans , Magnetic Resonance Imaging , Mental Processes
5.
Science
; 293(5530): 583-5, 2001 Jul 27.
Article
in English
| MEDLINE
| ID: mdl-11474073
6.
Science
; 293(5527): 27-8, 2001 Jul 06.
Article
in English
| MEDLINE
| ID: mdl-11441155
7.
Science
; 292(5525): 2233, 2001 Jun 22.
Article
in English
| MEDLINE
| ID: mdl-11423630
8.
Science
; 292(5521): 1467-8, 2001 May 25.
Article
in English
| MEDLINE
| ID: mdl-11379612
Subject(s)
Cysteine Endopeptidases/metabolism , Multienzyme Complexes/metabolism , Neurodegenerative Diseases/metabolism , Proteins/metabolism , Ubiquitins/metabolism , Animals , Cystic Fibrosis Transmembrane Conductance Regulator/chemistry , Cystic Fibrosis Transmembrane Conductance Regulator/metabolism , Humans , Huntingtin Protein , Nerve Tissue Proteins/chemistry , Nerve Tissue Proteins/metabolism , Nuclear Proteins/chemistry , Nuclear Proteins/metabolism , Proteasome Endopeptidase Complex , Protein Folding , Proteins/chemistry
9.
Science
; 292(5520): 1284-6, 2001 May 18.
Article
in English
| MEDLINE
| ID: mdl-11360975
10.
Science
; 292(5515): 185, 2001 Apr 13.
Article
in English
| MEDLINE
| ID: mdl-11305293
11.
Science
; 292(5515): 196-8, 2001 Apr 13.
Article
in English
| MEDLINE
| ID: mdl-11305304
12.
Science
; 291(5511): 2064-5, 2001 Mar 16.
Article
in English
| MEDLINE
| ID: mdl-11256391
13.
Science
; 291(5502): 229, 2001 Jan 12.
Article
in English
| MEDLINE
| ID: mdl-11253826
Subject(s)
Anti-HIV Agents/metabolism , Carrier Proteins/metabolism , HIV Envelope Protein gp41/metabolism , HIV/metabolism , Membrane Fusion , Peptides , AIDS Vaccines , Anti-HIV Agents/chemistry , CD4 Antigens/metabolism , CD4-Positive T-Lymphocytes/metabolism , CD4-Positive T-Lymphocytes/virology , Carrier Proteins/chemistry , Drug Design , HIV Envelope Protein gp41/chemistry , Humans , Protein Conformation , Protein Engineering , Protein Folding , Recombinant Proteins
14.
Science
; 291(5507): 1188, 2001 Feb 16.
Article
in English
| MEDLINE
| ID: mdl-11233430
15.
Science
; 291(5507): 1197, 2001 Feb 16.
Article
in English
| MEDLINE
| ID: mdl-11233438
16.
Science
; 291(5504): 567-9, 2001 Jan 26.
Article
in English
| MEDLINE
| ID: mdl-11229390
17.
Science
; 291(5504): 569-70, 2001 Jan 26.
Article
in English
| MEDLINE
| ID: mdl-11229391
18.
Science
; 291(5505): 806-7, 2001 Feb 02.
Article
in English
| MEDLINE
| ID: mdl-11225612
Subject(s)
Biofilms/growth & development , Nuclear Proteins , Saccharomyces cerevisiae Proteins , Saccharomyces cerevisiae/physiology , Cell Adhesion , Fungal Proteins/genetics , Fungal Proteins/metabolism , Fungal Proteins/physiology , Genes, Fungal , Glycoproteins/metabolism , Membrane Glycoproteins , Membrane Proteins/genetics , Membrane Proteins/physiology , Mutation , Plastics , Saccharomyces cerevisiae/genetics , Saccharomyces cerevisiae/growth & development , Trans-Activators/genetics , Trans-Activators/physiology
19.
Sci Aging Knowledge Environ
; 2001(1): oa2, 2001 Oct 03.
Article
in English
| MEDLINE
| ID: mdl-14602946
ABSTRACT
Alzheimer's disease (AD) afflicts 4 million people in the United States and is expected to strike 14 million by the year 2050, as the population ages. Researchers are scrambling to find genetic risk factors, decipher disease mechanisms, and develop reliable diagnostic tests that detect the illness at its earliest, potentially most treatable stage. Using these findings, they hope to devise new therapeutic approaches. Current clinical trials are testing novel techniques that stall or reverse AD-like neuropathology in mice.
Subject(s)
Alzheimer Disease , Alzheimer Disease/diagnosis , Alzheimer Disease/etiology , Alzheimer Disease/pathology , Alzheimer Disease/therapy , Animals , Humans
20.
Science
; 289(5482): 1123-5, 2000 Aug 18.
Article
in English
| MEDLINE
| ID: mdl-10970221
ABSTRACT
The secret of the success of Mycobacterium tuberculosis, the pathogen that causes tuberculosis, is that it can linger undetected in the lungs for decades, hiding from the immune system's macrophages that aim to chew it up and spit it out. Now a team of researchers has uncovered a vulnerability in this resilient bug that suggests new ways to starve it out of its bolt-hole.
