ABSTRACT
A method is described for blood collection from the lateral saphenous vein. This enables rapid sampling, which if necessary can be repeated from the same site without a need for new puncture wounds. The method is a humane and practical alternative to cardiac and retro-orbital puncture, in species where venepuncture has traditionally been regarded as problematic.
Subject(s)
Blood Specimen Collection/methods , Saphenous Vein , Animals , Cricetinae , Ferrets , Gerbillinae , Guinea Pigs , Mice , Mink , Rats , Species SpecificityABSTRACT
Ivermectin (22, 23-dihydroavermectin B 1) in subtoxic doses was administered subcutaneously to young adult DA rats. Prior to treatment the rats had been trained in a visual discrimination learning programme until their response pattern was stable. The behavioural response data were recorded during continued discrimination testing following the Ivermectin injection and compared with those of a control group. The results showed that the Ivermectin injection reduced the total number of lever presses and reinforcement collections. Further the treatment caused an increase in the total number of erroneous responses.
Subject(s)
Behavior, Animal/drug effects , Discrimination, Psychological/drug effects , Ivermectin/toxicity , Animals , Female , Male , Rats , Specific Pathogen-Free OrganismsSubject(s)
Animals, Newborn/physiology , Behavior, Animal/physiology , Rabbits/physiology , Animals , Female , Male , Rabbits/growth & development , RatsABSTRACT
Gut contents of nude and normal mice were examined by electron microscopy in association with an outbreak of diarrhea in a colony of nude mice. Virus-like particles with a morphology consistent with previous descriptions of astroviruses of other species were demonstrated in a high percentage of the animals.
Subject(s)
Diarrhea/veterinary , Mamastrovirus/isolation & purification , Mice, Nude/microbiology , Rodent Diseases/microbiology , Virus Diseases/veterinary , Viruses, Unclassified/isolation & purification , Animals , Diarrhea/microbiology , Mice , Microscopy, Electron , Virus Diseases/microbiologyABSTRACT
Pregnant Belted Dutch rabbits were administered lynestrenol (17-alpha-ethynyl-oestr-4-en-17-beta-ol) orally on days 6-18 of gestation at a dose of 0.5 mg/kg/day. The dose littered on term and the surviving offspring were observed until four weeks old. Neurological disturbances characterized by behavioural abnormalities and locomotor disabilities were observed. About 40% of the offspring died within four weeks, and more than 70% of these had congenital malformations.
