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4.
Rev Epidemiol Sante Publique ; 27(1): 51-15, 1979 Jul 19.
Article in French | MEDLINE | ID: mdl-515494

ABSTRACT

Incidence of cystic fibrosis has been estimated in three adjacent geographic areas of Brittany: North Finistere, South Finistere and Morbihan. This incidence is respectively 6.0 x 10(-4), 4.8 x 10(-4), 2.9 x 10(-4) in these three areas. A significant difference between North Finistere and Morbihan was found. Without proofs in favor of natural selection, genetic drift seems to be a possible explanation of this variation. Moreover, as in other studies, a genetic heterogeneity of the disease was not shown.


Subject(s)
Cystic Fibrosis/epidemiology , Cystic Fibrosis/genetics , France , Humans
5.
Tissue Antigens ; 12(3): 159-62, 1978 Sep.
Article in English | MEDLINE | ID: mdl-725903

ABSTRACT

In 94 children suffering from cystic fibrosis, no abnormal frequencies of HLA markers of the A and B locus were observed in comparison with the distribution of these antigens in control series. Furthermore, the HLA genotypes of seven pairs of diseased sibs are incompatible with the hypothesis of a closed linkage between CF--an autosomal recessive transmitted disease--and HLA.


Subject(s)
Cystic Fibrosis/genetics , HLA Antigens , Adolescent , Child , Child, Preschool , Female , Gene Frequency , HLA Antigens/analysis , Humans , Infant , Male , Pedigree
9.
Nouv Presse Med ; 2(28): 1879-80, 1973 Jul 14.
Article in French | MEDLINE | ID: mdl-4724384
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