ABSTRACT
In this paper, we investigate the universal approximation property of Radial Basis Function (RBF) networks. We show that RBFs are not required to be integrable for the REF networks to be universal approximators. Instead, RBF networks can uniformly approximate any continuous function on a compact set provided that the radial basis activation function is continuous almost everywhere, locally essentially bounded, and not a polynomial. The approximation in L(p)(micro)(1 < or = p < infinity) space is also discussed. Some experimental results are reported to illustrate our findings.
Subject(s)
Neural Networks, ComputerSubject(s)
Black People/genetics , Diabetes Mellitus, Type 1/immunology , HLA-DQ Antigens/genetics , HLA-DR Antigens/genetics , Immunity, Innate , Polymorphism, Genetic , Diabetes Mellitus, Type 2/immunology , Disease Susceptibility , Gene Frequency , HLA-DQ Antigens/analysis , HLA-DR Antigens/analysis , HLA-DR3 Antigen , Humans , Phenotype , Reference Values , United StatesABSTRACT
This review analyzes the local control rate of fast neutron beam teletherapy for malignant salivary gland carcinomas compared to conventional photon irradiation at the same institution. Thirty patients with malignant parotid or submaxillary gland tumors were treated with either cobalt-60 (19 patients) or neutrons +/- photons (11 patients). The 19 photon-treated patients were historical controls. No advantage is found for neutrons in patients with tumors less than 3 cm where 100% local control was achieved with either modality. In patients with tumor masses 3-6 cm in size, neutrons demonstrated a possible advantage with a local control rate of 100% (followup, 7-18 months) compared to a control rate of 33% with conventional photon irradiation. Acute treatment-related morbidity was slightly greater in neutron-treated patients, but no long-term complications have been observed to date.
Subject(s)
Fast Neutrons/therapeutic use , Neutrons/therapeutic use , Parotid Neoplasms/radiotherapy , Salivary Gland Neoplasms/radiotherapy , Submandibular Gland , Evaluation Studies as Topic , Humans , Parotid Neoplasms/pathology , Radiation Injuries , Radioisotope Teletherapy , Remission, Spontaneous , Salivary Gland Neoplasms/pathology , Skin/radiation effectsABSTRACT
Aleutian disease of mink is a viral illness characterized by systemic plasmocytosis and hypergammaglobulinemia. Some affected mink develop a monoclonal gammaglobulin spike and Bence-Jones proteinuria. A case of multiple myeloma in a mink handler with a 15-year history of exposure to Aleutian mink is presented. Previously reported cases of possible Aleutian disease (AD) in man are discussed and the pathogenesis of AD reviewed. Aleutian disease virus (ADV) may produce asymptomatic infection in exposed individuals. Available data suggest symptomatic disease in humans is extremely rare.
