Comparative Effectiveness of Surface Functionalized Poly-ε-Caprolactone Scaffold and ß-TCP Mixed PCL Scaffold for Bone Regeneration.

Physio-chemical surface properties to biomaterial has been attention in tissue engineering due to their properties on cell adhesion, proliferation, and differentiation. The object of this study is to evaluate the preosteoblast biological response on physio-chemical surface-layered 3D PCL scaffold and 3D PCL/ß-TCP scaffold. 3D scaffolds were fabricated by FDM 3D printing. Physio-chemical surface of 3D scaffolds were prepared by oxygen plasma and amine plasma-polymerization, respectively. The results of this study demonstrated that amine plasma-treated 3D scaffold on adhesion, proliferation, and osteogenic differentiation of the MC3T3-E1 was significantly increased compared to the other scaffolds.