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Reprod Toxicol ; 75: 10-22, 2018 01.
Article in English | MEDLINE | ID: mdl-29154916

ABSTRACT

The use of silver nanoparticles (AgNP) raises safety concerns during susceptible life stages such as pregnancy. We hypothesized that acute intravenous exposure to AgNP during late stages of pregnancy will increase vascular tissue contractility, potentially contributing to alterations in fetal growth. Sprague Dawley rats were exposed to a single dose of PVP or Citrate stabilized 20 or 110nm AgNP (700µg/kg). Differential vascular responses and EC50 values were observed in myographic studies in uterine, mesenteric arteries and thoracic aortic segments, 24h post-exposure. Reciprocal responses were observed in aortic and uterine vessels following PVP stabilized AgNP with an increased force of contraction in uterine artery and increased relaxation responses in aorta. Citrate stabilized AgNP exposure increased contractile force in both uterine and aortic vessels. Intravenous AgNP exposure during pregnancy displayed particle size and vehicle dependent moderate changes in vascular tissue contractility, potentially influencing fetal blood supply.


Subject(s)
Maternal Exposure/adverse effects , Metal Nanoparticles/toxicity , Muscle Contraction/drug effects , Muscle, Smooth, Vascular/drug effects , Pharmaceutical Vehicles/toxicity , Silver/toxicity , Animals , Aorta, Thoracic/drug effects , Citric Acid/toxicity , Female , Fetal Development/drug effects , Injections, Intravenous , Mesenteric Arteries/drug effects , Particle Size , Povidone/toxicity , Pregnancy , Rats, Sprague-Dawley , Surface Properties , Uterine Artery/drug effects
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