1.
Pharmazie
; 48(11): 854-5, 1993 Nov.
Article
in English
| MEDLINE
| ID: mdl-8295914
ABSTRACT
The induction of mutations at the HPRT locus and cytotoxicities of 4 vermiculin derivatives 2-4 and 6 were examined in V79 Chinese hamster cells and compared with those of the parent compound vermiculin (1). Derivatives prepared by hydrogenation were less toxic and mutagenic or non toxic and non mutagenic. The substitution at position 13 affected the evaluated biological effects. The results suggest that in vitro metabolism of vermiculin resulted in decreased cytotoxicity and mutagenicity.
Subject(s)
Antibiotics, Antineoplastic/chemical synthesis , Mutagens/chemical synthesis , Animals , Antibiotics, Antineoplastic/toxicity , Cell Line , Cell Survival/drug effects , Cricetinae , Cricetulus , Hypoxanthine Phosphoribosyltransferase/genetics , Lactones/chemical synthesis , Lactones/toxicity , Male , Mutagenicity Tests , Mutagens/toxicity , Rats , Rats, Wistar
2.
Biologia (Bratisl)
; 23(7): 536-40, 1968.
Article
in Slovak
| MEDLINE
| ID: mdl-5678317