ABSTRACT
We describe a case of a large chorioangioma diagnosed at 18 weeks' gestation. Because of advanced fetal heart failure at 23 weeks' gestation, embolization of the chorioangioma's vessels was performed by percutaneous injection of Glubran 2 surgical glue. There was no immediate secondary effect of treatment. Devascularization was complete and durable. Signs of fetal cardiac failure normalized after 1 month and a healthy infant was delivered at 38 weeks. To our knowledge this is the first reported case of perinatal survival after successful embolization of a chorioangioma using tissue glue.
Subject(s)
Cyanoacrylates/administration & dosage , Embolization, Therapeutic/methods , Hemangioma/therapy , Placenta Diseases/therapy , Pregnancy Complications, Neoplastic/therapy , Tissue Adhesives/administration & dosage , Adult , Female , Fetal Diseases/therapy , Gestational Age , Heart Failure/therapy , Hemangioma/diagnostic imaging , Humans , Infant, Newborn , Placenta Diseases/diagnostic imaging , Pregnancy , Pregnancy Complications, Neoplastic/diagnostic imaging , Pregnancy Outcome , UltrasonographyABSTRACT
Three related new cases with almost complete trisomy 11p due to paternal balanced translocation 46, XY, t(7; 11) (q36.1; p11.1) are reported. The proband (Case 1) was a malformed stillborn with exomphalos, case 2 was diagnosed in the first trimester by direct chromosome preparations from chorionic villi, and confirmed on fetal products after termination of pregnancy. Case 3, a cousin to cases 1 and 2, was a 29-weeks-old fetus with omphalocele discovered at ultrasound. Literature reports of trisomy 11p are reviewed with regard to those new cases, and the possible relationship of this chromosome imbalance with the Beckwith-Wiedemann Syndrome is discussed.
