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1.
Scand J Urol ; 55(1): 27-32, 2021 Feb.
Article in English | MEDLINE | ID: mdl-33380254

ABSTRACT

OBJECTIVE: To evaluate if MRI/ultrasound fusion based targeted biopsy (FBx) leads to a reduced rate of change in Gleason score (GS) compared to prostatectomy specimen. METHODS: The histopathological findings of the biopsy of the prostate and the radical prostatectomy (RP) specimen of 210 patients who were referred to our hospital between 2012 and 2017 were compared retrospectively in this study. One hundred and five patients who underwent FBx combined with ultrasound-guided 12-core biopsy of the prostate (SBx) were matched with 105 patients who underwent SBx only. This study evaluated the rate of up- or downgrading in the RP specimen in both groups and compared the results via matched pair analysis. RESULTS: Concordance in Gleason grade group (GGG) was found in 52/105 patients (49.5%) in SBx and in 49/105 patients (46.7%) with FBx (p = 0.679). The rate of downgrading was statistically significant (p = 0.014) and was higher in the FBx group (14/105 patients, 13.3%) than in the SBx group (4/105 patients, 3.8%). A higher rate of upgrading was seen in SBx (49/105 patients; 46.7%) compared to FBx (42/105 patients; 40%), with no statistical significance (p = 0.331). The change in GGG from biopsy to final pathology in patients with GGG 1 and 2 at biopsy level was not statistically significant (p = 0.168). CONCLUSION: FBx does not decrease the rate of upgrading between biopsy and final pathology in RP specimens. Our results indicate that FBx tends to overestimate the final GGG compared to SBx.


Subject(s)
Prostatic Neoplasms/pathology , Prostatic Neoplasms/surgery , Aged , Biopsy, Large-Core Needle , Humans , Image-Guided Biopsy , Magnetic Resonance Imaging , Male , Matched-Pair Analysis , Middle Aged , Neoplasm Grading , Postoperative Period , Retrospective Studies , Ultrasonography, Interventional
2.
Urologe A ; 56(11): 1430-1434, 2017 Nov.
Article in German | MEDLINE | ID: mdl-28983651

ABSTRACT

The resection of the primary tumor in patients with metastatic prostate cancer is controversially debated. Retrospective clinical studies indicate survival benefits and prevention of secondary, locoregional complications; however, results of ongoing multicenter prospective studies are still lacking. This review highlights the rationale behind the cytoreductive prostatectomy and summarizes current clinical study results.


Subject(s)
Bone Neoplasms/secondary , Bone Neoplasms/surgery , Cytoreduction Surgical Procedures/methods , Lymphatic Metastasis/pathology , Prostatectomy/methods , Prostatic Neoplasms/surgery , Bone Neoplasms/mortality , Bone Neoplasms/pathology , Combined Modality Therapy , Guideline Adherence , Humans , Male , Neoplasm Staging , Prostatic Neoplasms/mortality , Prostatic Neoplasms/pathology , Retrospective Studies
3.
Urologe A ; 56(7): 857-860, 2017 Jul.
Article in German | MEDLINE | ID: mdl-28349187

ABSTRACT

Primary prostatic sarcomas are rare, reportedly comprising less than 1% of all prostate malignancies. Most patients present with lower urinary tract symptoms due to bladder outlet obstruction. Prostate-specific antigen (PSA) is typically normal. Histological confirmation and staging by a computed tomography (CT) or magnetic resonance imaging (MRI) scan of the pelvis and abdomen are essential for diagnosis and treatment planning. The differential diagnosis includes sarcomatoid prostate cancer or benign spindle cell tumors. Primary prostatic sarcomas are often aggressive and require multimodal treatment with surgery and (neo)adjuvant radiation and/or chemotherapy. The risk of local recurrence is high and the long-term prognosis is poor.


Subject(s)
Prostatic Neoplasms/diagnosis , Sarcoma/diagnosis , Chemoradiotherapy, Adjuvant , Combined Modality Therapy , Diagnosis, Differential , Endosonography , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Neoplasm Recurrence, Local/etiology , Neoplasm Recurrence, Local/mortality , Prognosis , Prostate/pathology , Prostatectomy , Prostatic Neoplasms/mortality , Prostatic Neoplasms/pathology , Prostatic Neoplasms/therapy , Sarcoma/mortality , Sarcoma/pathology , Sarcoma/therapy , Survival Rate , Tomography, X-Ray Computed , Urinary Bladder Neck Obstruction/diagnosis , Urinary Bladder Neck Obstruction/etiology , Urinary Bladder Neck Obstruction/mortality , Urinary Bladder Neck Obstruction/pathology
5.
Urologe A ; 56(5): 599-603, 2017 May.
Article in German | MEDLINE | ID: mdl-28314971

ABSTRACT

BACKGROUND: Recent improvements in imaging diagnostics has led to a rising incidence of oligometastatic prostate cancer and, most notably, an increasing incidence of nodal-only biochemical recurrences. In this clinical setting, systemic therapy is still the treatment of choice. However, there is increasing evidence for surgical approaches in this challenging clinical setting. AIM OF THE STUDY: In this comprehensive review article, current evidence regarding surgical approaches of primary nodal metastases, nodal-only biochemical recurrence following radical prostatectomy, and osseous metastatic prostate cancer will be discussed. RESULTS: If nodal metastasis is clinically suspected, a significant survival benefit was observed in retrospective studies if radical prostatectomy and extended pelvic lymphadenectomy was performed within a multimodal therapeutic setting. Salvage lymphadenectomy as a therapeutic option for nodal-only biochemical recurrence is clinically feasible and can postpone systemic therapy significantly. However, since most patients do not have a lasting PSA response, a survival benefit of this therapeutic approach is questionable based on current evidence. Regarding osseous metastatic prostate cancer, the surgical approach has an inferior position compared to conservative management and radiotherapy. CONCLUSION: Evidence regarding a surgical approach towards oligometastatic prostate cancer is increasing. However, current evidence is mainly based on retrospective studies that were conducted in the pre-PSMA-PET/CT era.


Subject(s)
Clinical Decision-Making/methods , Lymph Node Excision/methods , Prostatectomy/methods , Prostatic Neoplasms/pathology , Prostatic Neoplasms/surgery , Sentinel Lymph Node/diagnostic imaging , Sentinel Lymph Node/surgery , Evidence-Based Medicine , Humans , Male , Neoplasm Metastasis , Prostatic Neoplasms/diagnostic imaging , Treatment Outcome
6.
Urologe A ; 55(5): 584-92, 2016 May.
Article in German | MEDLINE | ID: mdl-27142799

ABSTRACT

BACKGROUND: Prostate cancer (PCa) is the most common cancer in men, which is increasingly diagnosed at a localized stage due to the widespread use of PSA (prostate-specific antigen)-screening. METHOD: Traditionally, definite treatment options for PCa include radical prostatectomy, external beam radiotherapy, or brachytherapy. However, treatment-related side effects such as urinary incontinence and erectile dysfunction are common. Alternatively, national and international guidelines recommend active surveillance (AS) as a treatment option for low-risk PCa. Organ-preserving surgery is commonly used in other organs, such as organ-conserving surgery for breast cancer. Focal therapy (FT) for PCa may close the gap between radical treatment options and active surveillance while reducing side effects. AIM: This article highlights the current therapy options for FT in Germany including their limitations and perspectives. Currently, different therapy options are available for FT in PCa. However, the use of FT is still embedded in clinical trials and has not been approved for routine use yet. Initial results seem to be promising, but most studies are currently enrolling or have not been published yet.


Subject(s)
Biomarkers, Tumor/blood , Organ Sparing Treatments/methods , Prostatic Neoplasms/therapy , Guideline Adherence , Humans , Magnetic Resonance Imaging , Male , Neoplasm Staging , Prognosis , Prostate-Specific Antigen/blood , Prostatic Neoplasms/diagnosis , Prostatic Neoplasms/pathology , Watchful Waiting
7.
Aktuelle Urol ; 47(3): 203-9, 2016 05.
Article in German | MEDLINE | ID: mdl-27008434

ABSTRACT

Urinary tract infections are among the most common bacterial infectious diseases worldwide. Every second woman will experience at least one urinary tract infection in her lifetime. The administration of antibiotics has been a safe and efficient treatment modality so far. However, due to the emergence of multi-resistant pathogens and the developmental void of new antimicrobial drugs, the therapy of infections mighty become more challenging in the near future. So, knowledge of the complex host-pathogen interaction is of great importance. Common phenotypes observed in clinical practice suggest basic principles, which are relevant for the development of novel antimicrobial strategies. With invading pathogens forming intracellular bacterial communities they evade host response and provide a nidus for recurrent infection. A plethora of virulence factors allow uropathogenic bacteria to colonize and to establish infections in the urinary tract. In response, host responses seem to address specific virulence mechanisms that are essential to pathogenicity. Deciphering the molecular mechanisms underlying the complex host-pathogen interaction is critical to devise novel treatment options.


Subject(s)
Bacterial Infections/etiology , Escherichia coli Infections/etiology , Urinary Tract Infections/etiology , Anti-Bacterial Agents/therapeutic use , Bacterial Infections/drug therapy , Catheter-Related Infections/drug therapy , Catheter-Related Infections/etiology , Drug Resistance, Bacterial , Escherichia coli/pathogenicity , Escherichia coli Infections/drug therapy , Female , Humans , Recurrence , Urinary Catheters/microbiology , Urinary Tract Infections/drug therapy
8.
Urologe A ; 52(2): 193-6, 2013 Feb.
Article in German | MEDLINE | ID: mdl-23417045

ABSTRACT

The diagnostic work-up of lower urinary tract symptoms (LUTS) in the German guidelines consists of obligatory and optional diagnostic parameters. Recommendations for assessing LUTS include patient history, symptom questionnaires (IPSS international prostate symptoms score), physical examination, urine analysis, prostate-specific antigen, uroflowmetry, ultrasound examination of the urinary bladder, including postvoid residual urine and ultrasound examination of the upper urinary tract. Optional tests are voiding diary, pressure-flow studies, ultrasound measurement of detrusor wall thickness, urethrocystography and urethrocystoscopy. Ultrasound measurement of detrusor wall thickness in particular has a 95 % positive predictive value in diagnosing bladder outlet obstruction. With all diagnostic parameters it is possible to treat LUTS in a risk-adapted manner.


Subject(s)
Prostatic Hyperplasia/diagnosis , Cystoscopy , Disease Progression , Guideline Adherence , Humans , Lower Urinary Tract Symptoms/diagnosis , Lower Urinary Tract Symptoms/etiology , Male , Physical Examination , Predictive Value of Tests , Prostatic Hyperplasia/pathology , Surveys and Questionnaires , Ultrasonography , Urinalysis , Urinary Bladder, Overactive/diagnosis , Urinary Bladder, Overactive/etiology , Urodynamics/physiology , Urography
9.
Urologe A ; 52(2): 204-11, 2013 Feb.
Article in German | MEDLINE | ID: mdl-23417046

ABSTRACT

Phosphodiesterase-5 (PDE5) inhibitors, such as sildenafil, tadalafil and vardenafil are first line treatment for erectile dysfunction (ED). These PDE5 inhibitors are known to increase cyclic guanosine monophosphate (cGMP) concentrations in the smooth muscle cells of the corpora cavernosa penis by inhibiting PDE5, leading to smooth muscle relaxation. This mode of action is also believed to result in prostatic smooth muscle relaxation and to improve lower urinary tract symptoms (LUTS). Randomized controlled trials have shown beneficial effects on LUTS and on objective parameters such as maximum urinary flow rate (tadalafil). Based on these data tadalafil was recently approved for treatment of patients with male LUTS; however, the mechanisms leading to improvement of symptoms are still under debate.


Subject(s)
Phosphodiesterase 5 Inhibitors/therapeutic use , Prostatic Hyperplasia/drug therapy , Carbolines/adverse effects , Carbolines/therapeutic use , Controlled Clinical Trials as Topic , Cyclic GMP/metabolism , Cyclic Nucleotide Phosphodiesterases, Type 5/metabolism , Erectile Dysfunction/drug therapy , Erectile Dysfunction/pathology , Humans , Imidazoles/adverse effects , Imidazoles/therapeutic use , Lower Urinary Tract Symptoms/diagnosis , Lower Urinary Tract Symptoms/drug therapy , Lower Urinary Tract Symptoms/pathology , Male , Phosphodiesterase 5 Inhibitors/adverse effects , Piperazines/adverse effects , Piperazines/therapeutic use , Prostatic Hyperplasia/diagnosis , Prostatic Hyperplasia/pathology , Purines/adverse effects , Purines/therapeutic use , Sildenafil Citrate , Sulfones/adverse effects , Sulfones/therapeutic use , Tadalafil , Triazines/adverse effects , Triazines/therapeutic use , Urodynamics/drug effects , Vardenafil Dihydrochloride
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