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1.
Abdom Radiol (NY) ; 44(1): 72-84, 2019 01.
Article in English | MEDLINE | ID: mdl-30032383

ABSTRACT

PURPOSE: Corrected T1 (cT1) value is a novel MRI-based quantitative metric for assessing a composite of liver inflammation and fibrosis. It has been shown to distinguish between non-alcoholic fatty liver disease (NAFL) and non-alcoholic steatohepatitis. However, these studies were conducted in patients at high risk for liver disease. This study establishes the normal reference range of cT1 values for a large UK population, and assesses interactions of age and gender. METHODS: MR data were acquired on a 1.5 T system as part of the UK Biobank Imaging Enhancement study. Measures for Proton Density Fat Fraction and cT1 were calculated from the MRI data using a multiparametric MRI software application. Data that did not meet quality criteria were excluded from further analysis. Inter and intra-reader variability was estimated in a set of data. A cohort at low risk for NAFL was identified by excluding individuals with BMI ≥ 25 kg/m2 and PDFF ≥ 5%. Of the 2816 participants with data of suitable quality, 1037 (37%) were classified as at low risk. RESULTS: The cT1 values in the low-risk population ranged from 573 to 852 ms with a median of 666 ms and interquartile range from 643 to 694 ms. Iron correction of T1 was necessary in 36.5% of this reference population. Age and gender had minimal effect on cT1 values. CONCLUSION: The majority of cT1 values are tightly clustered in a population at low risk for NAFL, suggesting it has the potential to serve as a new quantitative imaging biomarker for studies of liver health and disease.


Subject(s)
Liver/diagnostic imaging , Magnetic Resonance Imaging/methods , Non-alcoholic Fatty Liver Disease/diagnostic imaging , Adult , Aged , Biological Specimen Banks , Female , Humans , Male , Middle Aged , Reference Values , Retrospective Studies , Risk Factors , United Kingdom
2.
Aliment Pharmacol Ther ; 47(5): 631-644, 2018 03.
Article in English | MEDLINE | ID: mdl-29271504

ABSTRACT

BACKGROUND: Validated diagnostic tools that are accurate, cost effective and acceptable to patients are required for disease stratification and monitoring in NAFLD. AIMS: To investigate the performance and cost of multiparametric MRI alongside existing biomarkers in the assessment of NAFLD. METHODS: Adult patients undergoing standard of care liver biopsy for NAFLD were prospectively recruited at two UK liver centres and underwent multiparametric MRI, blood sampling and transient elastography withing 2 weeks of liver biopsy. Non-invasive markers were compared to histology as the gold standard. RESULTS: Data were obtained in 50 patients and 6 healthy volunteers. Corrected T1 (cT1) correlated with NAFLD activity score (ρ = 0.514, P < .001). cT1, enhanced liver fibrosis (ELF) test and liver stiffness differentiated patients with simple steatosis and NASH with AUROC (95% CI) of 0.69 (0.50-0.88), 0.87 (0.77-0.79) and 0.82 (0.70-0.94) respectively and healthy volunteers from patients with AUROC (95% CI) of 0.93 (0.86-1.00), 0.81 (0.69-0.92) and 0.89 (0.77-1.00) respectively. For the risk stratification of NAFLD, multiparametric MRI could save £150,218 per 1000 patients compared to biopsy. Multiparametric MRI did not discriminate between individual histological fibrosis stages in this population (P = .068). CONCLUSIONS: Multiparametric MRI accurately identified patients with steatosis, stratifies those with NASH or simple steatosis and reliably excludes clinically significant liver disease with superior negative predictive value (83.3%) to liver stiffness (42.9%) and ELF (57.1%). For the risk stratification of NAFLD, multiparametric MRI was cost effective and, combined with transient elastography, had the lowest cost per correct diagnosis.


Subject(s)
Liver/diagnostic imaging , Magnetic Resonance Imaging , Non-alcoholic Fatty Liver Disease/diagnosis , Adolescent , Adult , Aged , Biopsy , Cost-Benefit Analysis , Elasticity Imaging Techniques/economics , Elasticity Imaging Techniques/methods , Female , Healthy Volunteers , Humans , Liver/pathology , Liver Cirrhosis/diagnosis , Liver Cirrhosis/economics , Magnetic Resonance Imaging/economics , Magnetic Resonance Imaging/methods , Male , Middle Aged , Non-alcoholic Fatty Liver Disease/economics , Non-alcoholic Fatty Liver Disease/pathology , Predictive Value of Tests , Young Adult
3.
Int J Obes (Lond) ; 29(6): 603-6, 2005 Jun.
Article in English | MEDLINE | ID: mdl-15738934

ABSTRACT

OBJECTIVE: To investigate the effect of viral inoculation by adenovirus 5 (Ad5) on body composition in a mouse model. DESIGN: Longitudinal monitoring before and after a single injection of virus or saline. SUBJECTS: Two groups of CD1 mice, one group given a single intraperitoneal dose of Ad5 and the control group, saline. MEASUREMENTS: Bodyweights and food intake were recorded before and up to 21 weeks after inoculation. At the end of the study, whole-body 1H magnetic resonance spectroscopy (MRS) and localised in vivo 1H MRS spectroscopy of the liver was performed to assess whole-body adiposity and intrahepatic lipid content, respectively. RESULTS: Ad5-treated animals gained significantly more weight over a period of 21 weeks after inoculation than the controls, 21.8 g (18.8-25.0) and 18.8 g (17.3-19.8) respectively, (P<0.05). The gain in bodyweight in the former animals arises from increased deposition of adipose tissue as measured by whole-body 1H MRS. Adiposity was 6.7% (3.10-11.20%), and 2.40% (0.85-5.65%) for the Ad5-treated and control animals, respectively (P<0.05). No significant difference in intrahepatic lipid content or food intake was observed between the two groups. CONCLUSION: The significantly higher percentage of adipose tissue in the Ad5-treated mice suggest viral infection may play a contributory role to a predisposition to obesity, although its contribution relative to other factors remains to be determined.


Subject(s)
Adenoviridae Infections/complications , Adenoviridae , Obesity/virology , Adenoviridae Infections/metabolism , Animals , Body Composition , Eating , Female , Lipids/analysis , Liver/metabolism , Magnetic Resonance Spectroscopy , Mice , Mice, Inbred Strains , Models, Animal , Obesity/metabolism , Time Factors , Weight Gain
4.
Lancet ; 358(9293): 1610-1, 2001 Nov 10.
Article in English | MEDLINE | ID: mdl-11716890

ABSTRACT

Tendons do not normally produce detectable signals with conventional magnetic-resonance techniques and are recognised as dark signal voids. However, if tendons are examined at 55 degrees to the static magnetic field (the "magic angle"), signals become detectable and the tendons can become the brightest structure on the image. We have used this approach to establish tendon relaxation times and magnetisation transfer ratios and to show contrast enhancement. We have also shown more detail of acute and chronic tendon rupture by this method compared with images made with the tendon parallel to the static magnetic field.


Subject(s)
Achilles Tendon/injuries , Magnetic Resonance Imaging/methods , Adult , Humans , Male , Middle Aged , Rupture
5.
Magn Reson Med ; 46(2): 354-64, 2001 Aug.
Article in English | MEDLINE | ID: mdl-11477640

ABSTRACT

High-signal artifacts produced by cerebrospinal fluid (CSF) flow can adversely affect fluid-attenuated inversion recovery (FLAIR) imaging of the brain and spinal cord. This study explores the use of a nonslice-selective inversion pulse to eliminate CSF flow artifacts together with a technique called "K-space Reordered by Inversion-time for each Slice Position" (KRISP) to achieve constant contrast in a multislice acquisition. Theory shows that with this method the CSF point spread function (PSF) has a minimum at the center and attenuated side lobes, providing CSF suppression, but residual edge signals remain. The PSF for brain is only mildly attenuated and signals for extended regions are not attenuated. KRISP FLAIR sequences were assessed in 15 patients (10 brain and five spinal cord cases). The images showed reduced CSF and blood flow artifacts and higher conspicuity of the cortex, meninges, ventricular system, brainstem, and cerebellum when compared with conventional FLAIR sequences.


Subject(s)
Artifacts , Central Nervous System Diseases/diagnosis , Cerebrospinal Fluid/physiology , Image Processing, Computer-Assisted , Magnetic Resonance Imaging/methods , Adult , Aged , Cerebrovascular Circulation , Computer Simulation , Female , Humans , Male , Middle Aged , Phantoms, Imaging , Rheology
6.
Clin Radiol ; 56(5): 375-84, 2001 May.
Article in English | MEDLINE | ID: mdl-11384135

ABSTRACT

AIM: The aim of this study was to compare the performance of three fluid attenuated inversion recovery (FLAIR) pulse sequences for control of cerebrospinal fluid (CSF) and blood flow artifacts in imaging of the brain. The first of these sequences had an initial sinc inversion pulse which was followed by conventional k-space mapping. The second had an initial sinc inversion pulse followed by k-space re-ordered by inversion time at each slice position (KRISP) and the third had an adiabatic initial inversion pulse followed by KRISP. MATERIALS AND METHODS: Ten patients with established disease were studied with all three pulse sequences. Seven were also studied with the adiabatic KRISP sequence after contrast enhancement. Their images were evaluated for patient motion artifact, CSF and blood flow artifact as well as conspicuity of the cortex, meninges, ventricular system, brainstem and cerebellum. The conspicuity of lesions and the degree of enhancement were also evaluated. RESULTS: Both the sinc and adiabatic KRISP FLAIR sequences showed better control of CSF and blood flow artifacts than the conventional FLAIR sequence. In addition the adiabatic KRISP FLAIR sequence showed better control of CSF artifact at the inferior aspect of the posterior fossa. The lesion conspicuity was similar for each of the FLAIR sequences as was the degree of contrast enhancement to that shown with a T(1)weighted spin echo sequence. CONCLUSION: The KRISP FLAIR sequence controls high signal artifacts from CSF flow and blood flow and the adiabatic pulse controls high signal artifacts due to inadequate inversion of the CSF magnetization at the periphery of the head transmitter coil. The KRISP FLAIR sequence also improves cortical and meningeal definition as a result of an edge enhancement effect. The effects are synergistic and can be usefully combined in a single pulse sequence. Curati, W. L.et al. (2001)Clinical Radiology56, 375-384


Subject(s)
Brain Diseases/diagnosis , Magnetic Resonance Imaging/methods , Adult , Aged , Artifacts , Brain Diseases/cerebrospinal fluid , Brain Diseases/physiopathology , Cerebrovascular Circulation/physiology , Contrast Media , Female , Humans , Male , Middle Aged
7.
AJNR Am J Neuroradiol ; 22(5): 896-904, 2001 May.
Article in English | MEDLINE | ID: mdl-11337335

ABSTRACT

BACKGROUND AND PURPOSE: Our purpose was to test a new variant of the fluid-attenuated inversion-recovery (FLAIR) sequence that was designed to reduce CSF and blood flow artifacts by use of a non-slice-selective inversion pulse and k-space reordered by inversion time at each slice position (KRISP). METHODS: With the KRISP FLAIR sequence, the slice order was cycled so that each inversion time (TI) was associated with a region of k-space rather than a particular slice, and the effective inversion time (TI(eff)) was chosen to null the signal from CSF. Scans were obtained with both conventional and KRISP FLAIR sequences. Studies were performed in 20 adult patients with a variety of brain diseases. Images were evaluated for artifacts from patient motion, CSF, and blood flow, and scored on a four-point scale. The conspicuity of the cortex, meninges, ventricular system, brain stem, and cerebellum was evaluated, as was lesion number and conspicuity. RESULTS: The KRISP FLAIR sequence showed more patient motion artifacts but had a pronounced advantage over the conventional sequence in control of CSF artifacts around the foramen of Munro, in the third ventricle, aqueduct, and fourth ventricle, as well as in the basal cisterns and around the brain stem and cerebellum. Blood flow artifacts from the internal carotid, basilar, and vertebral arteries were also much better controlled. Spurious high signal in the sylvian branches of the middle cerebral artery was eliminated. The meninges, cortex, ventricular system, brain stem, and cerebellum were better seen due to improved artifact suppression and an edge enhancement effect. CONCLUSION: The KRISP FLAIR sequence can suppress CSF and blood flow artifacts and improve the conspicuity of the meninges, cortex, brain stem, and cerebellum. Its major disadvantage is its duration, which may be reducible with a fast spin-echo version.


Subject(s)
Artifacts , Brain/pathology , Cerebrospinal Fluid , Cerebrovascular Circulation , Magnetic Resonance Imaging/methods , Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Reference Values , Time Factors
8.
Neurology ; 56(9): 1195-200, 2001 May 08.
Article in English | MEDLINE | ID: mdl-11342685

ABSTRACT

OBJECTIVE: To quantify structural changes in the substantia nigra of patients with PD with inversion recovery MRI and to compare these with striatal dopaminergic function measured with (18)F-dopa PET. METHODS: The authors studied 10 patients with PD and eight age-matched control subjects with a combination of MR sequences previously reported to be sensitive to nigral cell loss. Striatal regions of interest were defined on T1-weighted MRI coregistered to (18)F-dopa PET in all subjects. RESULTS: Discriminant function analysis of the quantified MR nigral signal correctly classified 83% of the combined PD patient/control group; three of 10 PD cases were incorrectly classified as "normal" (Wilks' lambda = 0.724, p > 0.05). Discriminant function analysis correctly classified 100% of PD patients and control subjects with (18)F-dopa PET based on mean caudate and putamen K(i) values (Wilks' lambda = 0.065, p < 0.001). Correlations between mean putamen K(i) and rostral and caudal nigral MR signal changes and mean caudate K(i) and caudal nigral MR signal changes were found (r = -0.76, -0.69, -0.80, p < 0.05). CONCLUSION: (18)F-dopa PET is more reliable than inversion recovery MRI in discriminating patients with moderately severe PD from normal subjects. However, the structural changes detected within the substantia nigra of patients with PD found using inversion recovery MRI correlate with measures of striatal dopaminergic function using (18)F-dopa PET.


Subject(s)
Brain/diagnostic imaging , Brain/pathology , Dihydroxyphenylalanine , Magnetic Resonance Imaging/methods , Parkinson Disease/diagnostic imaging , Parkinson Disease/pathology , Dihydroxyphenylalanine/analogs & derivatives , Humans , Middle Aged , Tomography, Emission-Computed
9.
J Comput Assist Tomogr ; 25(2): 251-6, 2001.
Article in English | MEDLINE | ID: mdl-11242224

ABSTRACT

The objective of this study was to compare conventional and KRISP (k-space reordered by inversion time at each slice position) fluid-attenuated inversion recovery (FLAIR) sequences in high grade gliomas for artifact control, conspicuity of intracranial structures, and lesions as well as sensitivity to contrast enhancement. Artifacts were lower with the KRISP FLAIR sequence, and the conspicuity of all assessed structures and lesions was better. The degree of contrast enhancement was similar with T1-weighted and KRISP FLAIR sequences.


Subject(s)
Artifacts , Astrocytoma/diagnosis , Brain Neoplasms/diagnosis , Magnetic Resonance Imaging/methods , Adult , Brain/pathology , Cerebrospinal Fluid , Cerebrovascular Circulation , False Positive Reactions , Female , Glioblastoma/diagnosis , Humans , Image Enhancement , Male , Middle Aged , Pulsatile Flow
10.
AJNR Am J Neuroradiol ; 22(2): 317-22, 2001 Feb.
Article in English | MEDLINE | ID: mdl-11156777

ABSTRACT

The purpose of this study was to investigate the possibility that some artifactual high signals produced in CSF with fluid-attenuated inversion-recovery MR sequences could be due to inhomogeneity in the amplitude of the initial inversion pulse, and that this problem could be reduced or eliminated by the use of adiabatic inversion pulses. Studies with four volunteers showed dependence of high CSF signals in the posterior fossa on radiofrequency pulse amplitudes and that these signals could be eliminated by the use of adiabatic inversion pulses. Two illustrative clinical cases are included.


Subject(s)
Brain/anatomy & histology , Cerebrospinal Fluid , Magnetic Resonance Imaging/methods , Magnetics , Adult , Artifacts , Brain/pathology , Brain Diseases/diagnosis , Humans , Male , Middle Aged , Models, Theoretical , Reference Values
11.
J Magn Reson Imaging ; 13(2): 313-7, 2001 Feb.
Article in English | MEDLINE | ID: mdl-11169840

ABSTRACT

Increased acquisition efficiency has been achieved by exciting several slices simultaneously. The mixed data were unfolded to produce separate slices using the spatial encoding information inherent in a multicoil receiver system. Each coil yields a linear combination of signals from all excited slices weighted by the sensitivity of each coil. A matrix inversion provides a solution to unfold these images.


Subject(s)
Image Processing, Computer-Assisted , Magnetic Resonance Imaging/instrumentation , Equipment Design , Fourier Analysis , Humans , Phantoms, Imaging , Sensitivity and Specificity , Time Factors
12.
J Magn Reson Imaging ; 12(5): 795-7, 2000 Nov.
Article in English | MEDLINE | ID: mdl-11050653

ABSTRACT

Foldover artifacts arise when the same imaging frequency occurs both at a desired location within a slice and at another location within the sensitive region of the radiofrequency (RF) coil. Foldover artifacts can be caused by nonlinearity in the gradient system and by inhomogeneity in B(0). This study investigates an approach in which an extra RF receiver coil and a postprocessing method are used to identify and remove foldover artifacts.


Subject(s)
Artifacts , Electromagnetic Fields , Image Enhancement/methods , Magnetic Resonance Imaging , Hand/anatomy & histology , Humans , Models, Theoretical , Sensitivity and Specificity
13.
Pediatrics ; 101(6): 957-62, 1998 Jun.
Article in English | MEDLINE | ID: mdl-9606219

ABSTRACT

OBJECTIVE: To investigate preterm infants, we have installed in our neonatal intensive care unit a dedicated magnetic resonance (MR) imaging system which was specifically designed for neonatal use. The aim of this study was to describe the MR appearances of the brain in preterm infants who were first scanned between 25 and 32 weeks gestational age (GA) and to outline changes to the brains of these infants between their first scan and term. METHODS: Preterm infants of 25 to 32 weeks GA were imaged using the 1T neonatal MR system (Oxford Magnet Technology, Eyensham, Oxfordshire, England/Picker International, Cleveland, OH). The scanning protocol included T1-weighted conventional spin echo (repetition time [TR], 600; echo time, 20 ms), inversion recovery fast spin echo (TR, 3530; effective echo time, 30; inversion time, 950 ms), and T2-weighted fast spin echo (TR, 3500; effective echo time, 208 ms) sequences. RESULTS: Seventeen infants of median 28 weeks GA (range, 24 to 31 weeks) at birth were imaged a total of 53 times between birth and term. The median number of images per infant was two (range, 1 to 9). In infants of < 30 weeks GA, the germinal matrix was visualized at the margins of the lateral ventricles. It had a short T1 and short T2 and the bulk of it involuted at between 30 and 32 weeks GA. The white matter had a relatively homogeneous low signal except for bands of altered signal (probably originating from regions containing radial glia and migrating cells) which were most apparent anterolateral and posterolateral to the lateral ventricles. Myelination was seen in the posterior brainstem, cerebellum, and region of the ventrolateral nuclei of the thalamus. Infants had very little cortical folding at 25 weeks GA but this developed later in an orderly fashion. CONCLUSION: The neonatal MR system allowed extremely preterm infants to be studied safely with MR imaging. The images acquired demonstrated the germinal matrix, early myelination, and early cortical folding. Evolution of these features was demonstrated with serial studies.


Subject(s)
Brain/anatomy & histology , Infant, Premature , Magnetic Resonance Imaging , Brain/physiology , Cerebral Cortex/anatomy & histology , Cerebral Cortex/physiology , Cerebral Ventricles/anatomy & histology , Cerebral Ventricles/physiology , Gestational Age , Humans , Infant, Newborn , Infant, Premature/physiology , Nerve Fibers, Myelinated
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