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Clin Exp Rheumatol ; 4(4): 347-50, 1986.
Article in English | MEDLINE | ID: mdl-3791717

ABSTRACT

Previous work from our laboratory has demonstrated a marked inhibitory activity of Auranofin (Au) and Gold Sodium Aurothiomalate (GST) on monocyte-macrophage function and an important role for macrophages in the pathogenesis of casein-induced experimental amyloidosis. In the present study we have looked at the in vivo effect of Au and GST on the inhibition of casein-induced macrophage activation and serum SAA levels. Au and GST markedly inhibited casein-induced macrophage activation while only Au reduced serum SAA levels to a significant degree. The present data raises the possibility that Au may be helpful in the treatment of secondary amyloid disease.


Subject(s)
Caseins/pharmacology , Gold/pharmacology , Macrophage Activation/drug effects , Macrophages/physiology , Serum Amyloid A Protein/blood , Animals , Chemotaxis, Leukocyte/drug effects , Complement C3/metabolism , Mice , Receptors, Fc/metabolism
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