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1.
Experientia ; 32(1): 77-9, 1976 Jan 15.
Article in English | MEDLINE | ID: mdl-129335

ABSTRACT

The (Na+ 4 K+)- and Mg2+-dependent ATPase distribution in several brain areas has been investigated in Quaking mutant mice characterized by myelin deficiency. A marked decrease of (Na+ + K+)-ATPase activity has been found in limbic structures, hypothalamus and cerebellum. The Mg2+-dependent activity did not change. A possible involvement of the impairment of the (Na+ + K+)-ATPase activity in the seizure susceptibility of this mice is discussed.


Subject(s)
Adenosine Triphosphatases/metabolism , Brain/enzymology , Epilepsy/enzymology , Animals , Brain/drug effects , Cerebellum/enzymology , Cerebral Cortex/enzymology , Chloromercuribenzoates/pharmacology , Fluorides/pharmacology , Hypothalamus/enzymology , Limbic System/enzymology , Magnesium/pharmacology , Male , Medulla Oblongata/enzymology , Mice , Myelin Sheath , Nerve Tissue Proteins/deficiency , Pons/enzymology , Potassium/pharmacology , Sodium/pharmacology
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