ABSTRACT
Aplastic anemia (AA) or acquired aplastic anemia is an uncommon and potentially fatal disease. It is defined as reduction of at least two peripheral blood series, associated with persistent bone marrow hypocellularity. It's association with pregnancy is even more uncommon, and it may result in high mortality for the mother and the child. We report an adolescent female with aplastic anemia, which worsened during pregnancy. Her hemoglobin was 5.2 g/dl, her leukocytes were 1,833/ul and her platelets were 19,000/ul. She was initially treated with cyclosporine and horse antithymocyte globulin without hematologic improvement. At 36 weeks of pregnancy methylprednisolone and platelet transfusions were used and a cesarean section was performed. Six month later she continues to require red blood cell and platelet transfusions.
Subject(s)
Anemia, Aplastic/therapy , Pregnancy Complications, Hematologic/therapy , Adolescent , Female , Humans , Infant, Newborn , Male , Pregnancy , Pregnancy Outcome , Severity of Illness IndexABSTRACT
Aplastic anemia (AA) or acquired aplastic anemia is an uncommon and potentially fatal disease. It is defined as reduction of at least two peripheral blood series, associated with persistent bone marrow hypocellularity. It's association with pregnancy is even more uncommon, and it may result in high mortality for the mother and the child. We report an adolescent female with aplastic anemia, which worsened during pregnancy. Her hemoglobin was 5.2 g/dl, her leukocytes were 1,833/ul and her platelets were 19,000/ul. She was initially treated with cyclosporine and horse antithymocyte globulin without hematologic improvement. At 36 weeks of pregnancy methylprednisolone and platelet transfusions were used and a cesarean section was performed. Six month later she continues to require red blood cell and platelet transfusions.
Subject(s)
Humans , Male , Female , Pregnancy , Infant, Newborn , Adolescent , Pregnancy Complications, Hematologic/therapy , Anemia, Aplastic/therapy , Severity of Illness Index , Pregnancy OutcomeABSTRACT
This study explored the toxic effects of crotoxin isolated from Crotalus durissus cumanensis venom on the ultrastructure of mice cardiac autonomic nervous system. Mice were intravenously injected with saline (control group) and crotoxin diluted in saline venom (study group) at a dose of 0.107 mg/kg mouse body weight. Samples from the inter-ventricular septum were prepared for electron microscopy after 6 h (G1), 12 h (G2), 24 h (G3) and 48 h (G4). The G1 group showed some cardiomyocyte with pleomorphic mitochondria. Capillary swollen walls, nerve cholinergic endings with depleted acetylcholine vesicles in their interior and other depletions were observed. A space completely lacking in contractile elements was noticed. The G2 group demonstrated a myelinic figure, a subsarcolemic region with few myofibrils and nervous cholinergic terminal with scarce vacuoles in their interior. The G3 group demonstrated a structure with a depleted axonic terminal, mitochondrias varying in size and enhanced electron density. In addition, muscular fibers with myofibrillar structure disorganization, a depleted nervous structure surrounded by a Schwann cell along with an abundance of natriuretic peptides, were seen. An amyelinic terminal with depleted Schwann cell and with scarce vesicles was also observed. Finally, axonic lysis with autophagic vacuoles in their interior and condensed mitochondria was observed in the G4 group. This work describes the first report of ultrastructural damage caused by crotoxin on mice cardiac autonomic nervous system.
Subject(s)
Autonomic Nervous System/drug effects , Autonomic Nervous System/ultrastructure , Crotalus , Crotoxin/toxicity , Heart/innervation , Acetylcholine/metabolism , Animals , Capillaries/drug effects , Capillaries/ultrastructure , Coronary Vessels/drug effects , Coronary Vessels/ultrastructure , Crotoxin/chemistry , Male , Mice , Microscopy, Electron, Transmission , Mitochondria, Heart/drug effects , Mitochondria, Heart/ultrastructure , Motor Neurons/drug effects , Motor Neurons/metabolism , Motor Neurons/ultrastructure , Myocytes, Cardiac/drug effects , Myocytes, Cardiac/ultrastructure , Nerve Endings/drug effects , Nerve Endings/ultrastructure , Sarcoplasmic Reticulum/drug effects , Sarcoplasmic Reticulum/ultrastructure , Schwann Cells/drug effects , Schwann Cells/ultrastructureABSTRACT
Mostrar la experiencia, beneficios, complicaciones y requerimientos técnicos de la cirugía laparoscópica durante el embarazo. Servicio de Cirugía Hospital Dr. Américo Babo, CVG Ferrominera Orinoco Puerto Ordaz. Estudio retrospectivo de las historias médicas de cinco pacientes embarazadas, con diferentes edades gestacionales, que ameritaron cirugía laparoscópica por presentar abdomen agudo quirúrgico, entre marzo de 1996 y diciembre del 2000. Los procedimientos realizados fueron dos colecistectomías, dos apendicectomías y una cistectomía ovárica. Todas las pacientes evolucionaron de forma satisfactoria, sin presentar trabajo prematuro de parto o pérdidas finalizando sus embarazos en condiciones normales. La cirugía laparoscópica puede ser realizada con seguridad en las pacientes embarazadas, siguiendo una serie de precauciones que eviten el riesgo de complicaciones. Discutimos nuestra experiencia y los reportes recientes de la literatura mundial
