ABSTRACT
The aim was to evaluate the effect of perinatal BPA exposure of one or both parents on the implantation index and expression of talin, occludin and E-cadherin in the uterine epithelial cells (UEC) of the offspring. Pregnant Wistar dams (F0) received BPA or vehicle from gestational day (GD) 6 to lactation day 21. F1 animals were mated forming four groups: Control dam-Control sire (Câ-Câ), BPA dam -Control sire (Bâ-Câ), Control dam -BPA sire (Câ-Bâ), BPA dam -BPA sire (Bâ-Bâ). F1 dams were sacrificed at GD 6. Significantly decreased number of implantation sites was observed in the Bâ-Bâ group as compared to the Câ-Câ group, which correlated with decreased talin apical/basal expression ratio, occludin apical expression, and E-cadherin apical/lateral expression ratio in the UEC. Furthermore, decreased E-cadherin expression in the blastocyst was observed. Our data suggest that reduced protein expressions in F1 BPA offspring could result from decreased progesterone serum levels.
