ABSTRACT
La fibrosis pulmonar idiopática es una patología sobre la cual se está incidiendo tanto en el diagnóstico, a través de estudios acerca de las alteraciones genéticas que modifican el curso de la enfermedad, como en estudios que nos aportan diferentes alternativas en cuanto al tratamiento. Actualmente disponemos de dos fármacos que han demostrado mejorar tanto el pronóstico de la enfermedad como la calidad de vida de los pacientes que se someten a dichos tratamientos, ellos son Pirfenidona y Nintedanib
Idiopathic pulmonary fibrosis is a pathology that is affecting both the diagnosis, through studies about genetic alterations that modify the course of the disease and studies that provide us with different treatment alternatives. We currently have two drugs that have been shown to improve both the prognosis of the disease and the quality of life of patients who undergo such treatments, such as Pirfenidone and Nintedanib
Subject(s)
Humans , Male , Middle Aged , Idiopathic Pulmonary Fibrosis/drug therapy , Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors , Protein-Tyrosine Kinases/antagonists & inhibitors , Treatment Outcome , Anti-Inflammatory Agents/therapeutic useABSTRACT
CLINICAL CASE: A fair-skinned woman presented marked striate melanokeratosis in her left eye related to recurrent corneal erosion. The source of pigmentation was a conjunctival melanosis. The conjunctival melanosis responded to treatment with topical mitomycin, while the corneal pigmentation persisted. DISCUSSION: Striate melanokeratosis is a condition described in dark-skinned patients who show a well-defined pigmentation of the limbal area, with only one case of striate melanokeratosis reported previously in a Caucasian person. The stimuli for this proliferation are corneal lesions or melanosis close to the limbus. Avoiding both stimuli are the main steps in its management.
Subject(s)
Conjunctival Diseases/etiology , Corneal Diseases/etiology , Corneal Ulcer/complications , Limbus Corneae/pathology , Melanosis/etiology , Conjunctival Diseases/drug therapy , Conjunctival Diseases/pathology , Corneal Diseases/drug therapy , Corneal Diseases/pathology , Eye Color , Female , Fluorometholone/administration & dosage , Fluorometholone/therapeutic use , Humans , Melanosis/drug therapy , Melanosis/pathology , Middle Aged , Mitomycin/administration & dosage , Mitomycin/therapeutic use , Ophthalmic Solutions , Recurrence , White PeopleABSTRACT
Caso clínico: Se presenta el caso de una mujer deraza blanca y piel clara, con erosión corneal recurrentey con melanosis conjuntival en OI, que desarrollóuna opacidad corneal por melanoqueratosis estriada.La melanosis conjuntival se trató con mitomicinatópica, manteniendo la pigmentación corneal.Discusión: La melanoqueratosis estriada se presentaen personas de piel oscura, con un único casodescrito en personas de raza caucásica. Ésta se originapor daño corneal o por migración de pigmentodesde melanosis conjuntivales, debiendo tratarambas condiciones para detener la pigmentación corneal(AU)
Clinical case: A fair-skinned woman presented markedstriate melanokeratosis in her left eye related torecurrent corneal erosion. The source of pigmentationwas a conjunctival melanosis. The conjunctivalmelanosis responded to treatment with topicalmitomycin, while the corneal pigmentation persisted.Discussion: Striate melanokeratosis is a conditiondescribed in dark-skinned patients who show awell-defined pigmentation of the limbal area, withonly one case of striate melanokeratosis reportedpreviously in a Caucasian person. The stimuli forthis proliferation are corneal lesions or melanosisclose to the limbus. Avoiding both stimuli are themain steps in its management(AU)
Subject(s)
Humans , Female , Middle Aged , Keratosis/complications , Keratosis/diagnosis , Keratosis/drug therapy , Melanosis/complications , Melanosis/diagnosis , Mitomycin/therapeutic use , Administration, Topical , Corneal Diseases/complications , Corneal Diseases/drug therapy , Visual Acuity , Visual Acuity/physiology , Conjunctiva , Conjunctiva/pathology , Conjunctival Diseases/complicationsABSTRACT
Methods for cytogenetic prenatal diagnosis available in México require from women to accept the risk of procedures and to take a decision in the case of an abnormal result. We applied a questionnaire to 264 pregnant women from August 1990 to July 1991 with the purpose of describing the characteristics of these women and the factors involved in making the decision. Two hundred and nine patients (79%) accepted the procedures. The acceptance was related with a high level of studies and inversely related to their religious beliefs. The interviewer did not influence the decision; but it was important to have previous information about the procedures. Those women with the highest social, financial, and study level and those who did not practice their religion accepted the possibility of an abortion.
