ABSTRACT
The cytopathologic features of the fine needle aspiration cytology of the local recurrence of a vulvar epithelioid sarcoma were documented. The cytologic findings included round polygonal cells with abundant eosinophilic cytoplasm and an eccentrically located nucleus. Despite their epithelioid aspect, the cells in the smears had a sarcomatous arrangement, consisting of isolated cells and loosely cohesive groups. The cytologic findings correlated well with the histologic features of the tumor, which consisted of nodules of eosinophilic epithelioid cells. We discuss the clinical characteristics and prognostic factors in this unusual, vulvar location of this soft tissue sarcoma.
Subject(s)
Neoplasm Recurrence, Local/pathology , Sarcoma/pathology , Vulvar Neoplasms/pathology , Biopsy, Needle , Fatal Outcome , Female , Humans , Middle Aged , Neoplasm Recurrence, Local/diagnosis , Sarcoma/diagnosis , Vulvar Neoplasms/diagnosisABSTRACT
The neurotoxic effects of two glutamate agonists, kainic acid (KA) and monosodium glutamate (MSG), were analyzed in the pigmented rat cochlea. Neural damage occurring after KA or MSG treatments were evidenced by the presence of a majority of swollen fibers in the inner spiral bundle. The use of diltiazem (DI), a Ca2+ L-channel antagonist, to prevent cochlear neural damage induced by glutamate agonists resulted in a significant increase of unswollen afferent nerve fibers. MSG-treated animals, after DI pretreatment, recovered the normal latency of the compound action potential, and only unswollen nerve fibers were observed.
Subject(s)
Cochlea/innervation , Diltiazem/pharmacology , Kainic Acid/adverse effects , Nerve Fibers/drug effects , Neurons, Afferent/drug effects , Sodium Glutamate/adverse effects , Action Potentials/physiology , Animals , Cochlea/drug effects , Cochlea/physiology , Male , Microscopy, Electron , Rats , Rats, Inbred StrainsABSTRACT
A case of neurilemoma of the left breast in an 83-year-old man is presented, including the fine needle aspiration and biopsy diagnosis. A review of the literature did not reveal the existence of such a tumor in a man's breast. The aspirate yielded a cellular smear composed of clusters of spindle-shaped cells showing minimal atypia and Verocay bodies. The final diagnosis was established on the excised mass through histopathologic study.
Subject(s)
Breast Neoplasms/pathology , Neurilemmoma/pathology , Aged , Aged, 80 and over , Biopsy, Needle , Humans , MaleABSTRACT
A Zollinger-Ellison syndrome due to an ovarian mucinous cystadenoma of borderline malignancy is reported in a 76-year-old woman. Immunostaining procedures showed reactivity for gastrin in neoplastic cells. After operation, the patient has remained without symptoms for 6 years. This is the fifth case reported in the literature. All of these ovarian tumors were considered mucinous cystadenomas histologically.
