ABSTRACT
Introduction. SIOPEN INES protocol yielded excellent 5-year survival rates for MYCN-non-amplified metastatic neuroblastoma. Patients deemed ineligible due to lack or delay of MYCN status or late registration were treated, but not included in the study. Our goal was to analyse survival at 10 years among the whole population. Materials and methods. Italian and Spanish metastatic INES patients data are reported. SPSS 20.0 was used for statistical analysis. Results. Among 98 infants, 27 had events and 19 died, while 79 were disease free. Five- and 10-year event-free survival (EFS) were 73 and 70 %, and overall survival (OS) was 81 and 74 %, respectively. MYCN status was significant for EFS, but not for OS in multivariate analysis. Conclusions. The survival rates of patients who complied with all the inclusion criteria for INES trials are higher compared to those that included also not registered patients. Five-year EFS and OS for INES 99.2 were 87.8 and 95.7 %, while our stage 4s population obtained 78 and 87 %. Concerning 99.3, 5-year EFS and OS were 86.7 and 95.6 %, while for stage 4 we registered 61 and 68 %. MYCN amplification had a strong impact on prognosis and therefore we consider it unacceptable that many patients were not studied for MYCN and probably inadequately treated. Ten-year survival rates were shown to decrease: EFS from 73 to 70 % and OS from 81 to 74 %, indicating a risk of late events, particularly in stage 4s. Population-based registries like European ENCCA WP 11-task 11 will possibly clarify these data (AU)
No disponible
Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Neuroblastoma/complications , Neuroblastoma/diagnosis , Neoplasm Metastasis/diagnosis , Neoplasm Metastasis/physiopathology , Eligibility Determination/standards , Prognosis , Clinical Protocols , 28599 , Survivorship/physiology , Informed Consent/standardsABSTRACT
Introducción: la atopia se define como la tendencia a producir anticuerpos IgE específicosfrente a alérgenos y se expresa clínicamente como dermatitis-eccema, asma y rinoconjuntivitis. En los últimos años se ha documentado el aumento de la prevalencia de atopia en los países desarrollados. La detección de los alérgenos implicados es necesaria para unas medidas terapéuticasóptimas.El objetivo del estudio es describir el perfil de sensibilizaciones en los niños con atopia delmunicipio de Zaragoza. Material y métodos: durante el verano de 2009 se revisaron las historias clínicas de los niñosde 0-14 años, de las consultas de 6 pediatras de Atención Primaria. Se obtuvo una muestrade 194 niños con clínica y estudio alérgico positivo en los últimos 5 años. Resultados: distribución por sexo: 62,9% varones y 37,1% mujeres. Hallazgos clínicos: asma:78%, rinitis: 68%, conjuntivitis: 50% y dermatitis: 29%; con frecuencia se asociaron diferentes diagnósticos. Los alérgenos positivos fueron: gramíneas: 48%, hongos: 35%, árboles: 34%, animales: 26%, alimentos: 24%, ácaros: 19% y malezas: 18%. Conclusiones: las causas más importantes de sensibilización en nuestro estudio son primerolas gramíneas y luego la Alternaria; olivo, animales, ácaros y malezas les siguen por este orden.En nuestra zona geoclimática, si hay síntomas en invierno o al final del verano se debe estudiarel ciprés, plátano de sombra, Chenopodium y Salsola. La alta sensibilización a alimentosencontrada se corresponde con otros estudios. La identificación de las sensibilizaciones permiterelacionarlas con la clínica, tomar las medidas terapéuticas oportunas y mejorar la calidad de vidade los niños (AU)
Introduction: atopy is defined as the tendency to produce allergen-specific IgE antibodiesand is expressed clinically as dermatitis, eczema, bronchial asthma and rhino-conjunctivitis. Inthe last years, an increased prevalence of atopy in developed countries has been documented.The detection of allergens involved is necessary for optimal therapeutic measures. The aim ofthis study is to describe the profiles of sensitizations in children with atopy in the municipalityof Zaragoza.Material and methods: in the summer of 2009 the clinical histories of 0-14 year-old children,of 6 pediatricians consultations were reviewed. A sample of 194 children with clinicalfindings and allergic positive study in the last 5 years was collected.Results: distribution between sexes: 62.9% male and 37.1% female. Clinical findings:78% asthma, 68% rhinitis, 50% conjunctivitis and 29% dermatitis; often several diagnoseswere associated. The allergens found were: 48% gramineae, 35% fungi, 34% trees, 26% animals,24% food, 19% dust-mites and 18% weeds.Conclusions: the most important causes of sensitization in our study are gramineae in thefirst place followed by Alternaria. Olive tree, animals, dust-mites and weeds follow them in thisorder. We must study cypress, platanus orientalis and Chenopodium, and Salsola, which areprevalent in our geoclimatic zone, if there are symptoms in winter or in late summer. The high sensitization to food matches other studies. The identification of the sensitizations will allow usto relate them to the clinic, take the appropriate therapeutic measures and to improve the quality of life of these children (AU)
Subject(s)
Humans , Male , Female , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Allergy and Immunology/standards , Hypersensitivity/diagnosis , Immunoglobulin E/analysis , Receptors, IgE/immunology , Asthma/immunology , Primary Health Care/methods , Primary Health Care/trends , Conjunctivitis/immunology , Conjunctivitis, Allergic/immunology , Dermatitis/immunology , Rhinitis/immunology , Retrospective StudiesABSTRACT
No disponible
Subject(s)
Humans , Growth Disorders/therapy , Growth Hormone/therapeutic use , Gonadotropin-Releasing Hormone/analogs & derivatives , Diagnosis, Differential , Aromatase Inhibitors/therapeutic useABSTRACT
Las anomalías del arco aórtico derecho se adscriben a un grupo de malformaciones poco frecuentes y escasamente descritas en la bibliografía en su forma prenatal; sin embargo, no es infrecuente hallarlas como causa de patología respiratoria o digestiva (refractarias a tratamiento) en pacientes adultos e incluso como procesos vasculares severos con morbimortalidad elevada. La relación de los grandes vasos con la tráquea en el mediastino alto, en el estudio fetal, permite un diagnóstico relativamente sencillo, cuando se contempla su posibilidad diagnóstica
The use of the three vessels and trachea view, described by Yagel in 2001, allows diagnosis of aortic arch malformations, which can help to guide fetal chromosome study and identify patients who will benefit from lifelong follow-up. Right-sided aortic arch anomalies belong to a group of infrequent malformations. Few cases of prenatal forms have been described in the literature. Nevertheless, it is not infrequent to find these anomalies as the cause of respiratory or digestive disease (refractory to treatment) in adult patients and even as severe vascular processes with high morbidity and mortality. The position of the great vessels in relation to the trachea at the level of the superior mediastinum in fetal study allows a relatively simple diagnosis, especially when the diagnostic possibilities are considered
Subject(s)
Female , Pregnancy , Adult , Humans , Aorta, Thoracic/abnormalities , Ultrasonography, Prenatal/methods , Cardiovascular Abnormalities , Pregnancy Complications, Cardiovascular , Subclavian Artery/abnormalitiesABSTRACT
Se estudian las características psicológicas en niños diagnosticados de acondroplasia que se someterán a un alargamiento quirúrgico óseo de sus extremidades.Se analizó el perfil psicológico, cociente intelectual e integración social de estos niños de baja estatura, cuyas edades oscilan entre los 7 y 12 años, para ello se ha realizado una valoración psicológica previa a la intervención, mediante pruebas de inteligencia WISC-R, pruebas proyectivas, cuestionario de adaptación, una entrevista semiestructurada y el cuestionario Child Behavior Checklist a los padres, además del informe escolar.Los resultados obtenidos han permitido observar tendencias psicológicas características en los niños de baja estatura, encontrándose que aparecen más inseguros, dependientes, introvertidos, retraídos, con una baja autoestima y autodesvalorización, y con tendencia a la tiranización, en comparación con el grupo control.La media obtenida en el cociente intelectual estaba dentro de los límites de la normalidad (AU)
