ABSTRACT
Resumen OBJETIVO: Evaluar los desenlaces con la aplicación del balón de Bakri para contener la hemorragia posparto. MATERIALES Y MÉTODOS: Estudio descriptivo, analítico, observacional y retrospectivo efectuado en pacientes atendidas en el Hospital Central, San Luis Potosí, a quienes de enero 2012 a diciembre 2017 se les colocó un balón de Bakri para contener la hemorragia posparto. Se excluyeron los expedientes incompletos y las pacientes a quienes se colocó el balón en otra institución. El análisis estadístico se procesó en una hoja de Excel Office 2013. RESULTADOS: Se realizaron 143 colocaciones del balón de Bakri, 84.06% (n = 121) durante el posparto, 9% (n =13) en la poscesárea y 6.2% (n = 9) durante la cesárea. La colocación del balón se consideró exitosa en 90.2% (n = 129); hubo 14 (9.79%) fallas en el control de la hemorragia que ameritaron otro procedimiento. El 48.9% de las pacientes no tenían factores de riesgo. El promedio de permanencia del balón fue de 20 h. Se registró una muerte obstétrica directa, por choque hipovolémico. CONCLUSIONES: El éxito del balón de Bakri para contener la hemorragia obstétrica fue similar al reportado en la bibliografía. Su aplicación es una estrategia de segunda línea, secundaria a atonía y complicaciones bajas.
Abstract OBJECTIVE: To evaluate the outcomes with the application of the Bakri balloon to contain postpartum hemorrhage. MATERIALS AND METHODS: Descriptive, analytical, observational and retrospective study carried out in patients attended at the Central Hospital in San Luis Potosi who between the months of January 2012 to December 2017 had a Bakri balloon placed to contain postpartum hemorrhage. Incomplete records and patients who had the balloon placed in another institution were excluded. Statistical analysis was processed in an Excel Office 2013 spreadsheet. RESULTS: 143 Bakri balloon placements were performed, 84.06% (n = 121) during postpartum, 9% (n =13) post cesarean section and 6.2% (n = 9) during cesarean section. Balloon placement was considered successful in 90.2% (n = 129); there were 14 (9.79%) failures to control bleeding that warranted another procedure. Of the patients, 48.9% had no risk factors. The average length of stay was 20 hours. One direct obstetric death was recorded, due to hypovolemic shock. CONCLUSIONS: The success of the Bakri Balloon in containing obstetric hemorrhage was similar to that reported in the literature. Its application is a second line strategy, secondary to atony and low complications.
ABSTRACT
OBJECTIVE: The presence in the brain of α-synuclein containing Lewy neurites, or bodies, is the histological hallmark of Parkinson's disease (PD). The discovery of α-synuclein aggregates in nerve endings of the heart, digestive tract, and skin has lent support to the concept of PD as a systemic disease. Our goals were, first, to demonstrate the presence of α-synuclein inclusions in the skin and, second, to detect quantitative differences between patients with PD and atypical parkinsonism (AP). METHODS: Skin biopsies were taken from 67 patients and 20 controls. The biopsies underwent immunohistochemistry (IHC) and immunofluorescence (IF) testing for α-synuclein, whereupon its presence was quantified as the percentage of positive cells. Patients were divided into those with PD and those with AP. AP patients included AP with neurodegenerative disease (proteinopathies) and secondary AP. RESULTS: Sixty-seven patients (34 with PD) and 20 controls were recruited. In the PD group, α-synuclein was detected in 58% of the cells in the spinous cell layer (SCL), 62% in the pilosebaceous unit (PSU), and 58% in the eccrine glands (EG). The AP-proteinopathies group showed 7%, 7%, and 0% expression of α-synuclein, respectively. No expression was found in the skin of the control group. CONCLUSIONS: The expression of α-synuclein in the skin was relatively high in the PD group, scarce in AP, and null for the individuals in the control group. While these findings require further confirmation, this minimally invasive technique may aid in the improvement of the accuracy of PD diagnoses.
