ABSTRACT
The experiment was carried out on Wistar rat males weighting about 200 g. Animals from experimental group I received 20% ethanol for drinking (ad libitum), animals from experimental group II--cephalexin in the dose of 42 mg/24 h, animals from experimental group III--cephalexin and ethanol in mentioned doses. After 10 days animals were decapitated and specimens of the stomach were taken from the greater curvature. It was stated that 10-day administration of 20% ethanol causes hyperemia of the gastric mucous membrane and the decrease of secretory activity of the glands. On the contrary, cephalexin causes the increase of secretory activity of chief and parietal cells. Concomitant administration of ethanol and cephalexin damages the gastric mucous membrane causing its narrowing, flattening of gastric pits and atrophy of secretory cells in the glands.
Subject(s)
Alcohol Drinking/adverse effects , Cephalexin/toxicity , Chief Cells, Gastric/drug effects , Ethanol/toxicity , Gastric Mucosa/drug effects , Parietal Cells, Gastric/drug effects , Animals , Atrophy/pathology , Cell Count , Chief Cells, Gastric/pathology , Drug Synergism , Gastric Mucosa/pathology , Male , Parietal Cells, Gastric/pathology , Rats , Rats, WistarABSTRACT
The Wistar rat males weighing approximately 200 g were administered 20% ethanol ad libitum during 10 days, cephalexin in the dose of 42 mg/24 h, and simultaneously ethanol and cephalexin in the above-mentioned doses. After 10 days the animals were decapitated and stomach specimens were taken from the major curvature region for examinations. They were fixed in 10% formalin, dehydrated and immersed in paraffin. For the purpose of estimation changes in activity of gastric gland mucous cells Mc Manus's PAS reaction was performed on 7 micro-thick sections. It was found that ethanol causes functional decrease in the activity of mucous cells. However, cephalexin increases the activity of superficial mucous cells and orifice mucous cells of gastric glands, and inhibits the activity of cervix mucous cells. A simultaneous administration of ethanol and cephalexin causes atrophic changes in gastric glands, and thereby strong reduction of mucous cells activity.
Subject(s)
Alcohol Drinking/adverse effects , Anti-Bacterial Agents/toxicity , Cephalexin/toxicity , Ethanol/toxicity , Gastric Mucosa/drug effects , Animals , Drug Synergism , Gastric Mucosa/pathology , Male , Rats , Rats, Wistar , Secretory Rate/drug effectsABSTRACT
The purpose of the studies was to assess the electrolyte concentration in blood serum of pregnant Wistar rats, in which pregnancy coexisted with adriamycin-induced nephrotic syndrome. The results displayed hiponatremia in serum blood of these female rats. After puerperium sodium concentration came to the level similar to that before pregnancy, in comparison to control. Hiponatremia could cause neurological complications, which in pregnancy could activate eclampsia.
