ABSTRACT
OBJECTIVE: We evaluated temporal 67gallium (Ga) uptake in temporal arteritis (TA) and the contribution of Ga scans to the diagnosis of TA. METHODS: Ga scans were performed prospectively in 19 patients with biopsy-proven TA and five TA patients with negative temporal artery biopsy. Controls were 18 elderly patients undergoing Ga scans for various inflammatory diseases. The temporal region of interest on head profiles was defined for comparison of uptake with a control parietal region of the same area. The Ga uptake ratio (GaUR) [(temporal region - parietal region)/parietal region] was evaluated for each temple by a computer and intra- and intergroup comparisons were made. RESULTS: GaUR was significantly higher in biopsy-proven TA patients (0.35+/-0.19) and biopsy-negative TA patients (0.31+/-0.03) than in controls (0.18+/-0.12) (P < 0.001), independently of recent temporal artery biopsy or short-duration steroid therapy. High GaUR (>0.4) had a 94% specificity and a 90% positive predictive value for TA diagnosis. After 6 months of steroid therapy, when patients were in remission, GaUR returned to baseline. CONCLUSION: Ga is specifically incorporated into the temporal area in TA patients which may be due to the granulomatous vasculitic process. Ga uptake ceases during remission. A high GaUR may contribute to TA diagnosis in temporal artery biopsy-negative patients and its role in the diagnosis of other localizations of the disease requires further evaluation.
Subject(s)
Gallium Radioisotopes , Giant Cell Arteritis/diagnostic imaging , Adrenal Cortex Hormones/therapeutic use , Aged , Aged, 80 and over , Female , Giant Cell Arteritis/drug therapy , Humans , Inflammation/diagnostic imaging , Male , Middle Aged , Prospective Studies , Radionuclide ImagingSubject(s)
Candidiasis , Discitis/microbiology , Adolescent , Adult , Aged , Aged, 80 and over , Humans , Middle AgedSubject(s)
Peritonitis/etiology , Pneumococcal Infections/complications , Salpingitis/complications , Adult , Amoxicillin/therapeutic use , Ceftriaxone/therapeutic use , Cephalosporins/therapeutic use , Female , Follow-Up Studies , Humans , Penicillins/therapeutic use , Peritonitis/diagnosis , Peritonitis/drug therapy , Pneumococcal Infections/diagnosis , Pneumococcal Infections/drug therapy , Salpingitis/diagnosis , Time Factors , Tomography, X-Ray ComputedABSTRACT
We report two cases of bone and joint amyloidosis involvement related to plasma cell dyscrasia. The radiographic appearances mimic numerous benign or malignant diseases. MR imaging shows a diffuse low signal in T1 and an heterogeneous low or mild low signal in T2 weighted spin-echo sequence.
Subject(s)
Amyloidosis/complications , Dysgammaglobulinemia/complications , Joint Diseases/blood , Spinal Diseases/diagnostic imaging , Aged , Female , Humans , Joint Diseases/complications , Joint Diseases/diagnostic imaging , Magnetic Resonance Imaging , Male , Middle Aged , Plasmacytoma/diagnosis , Radiography, Thoracic , Spine/diagnostic imagingABSTRACT
Discovery on a protein electrophoregram of a bisalbuminemia can orientate according to its migration fast or slow to an hereditary mutation of an amino acid, or an acquired form by excess of beta lactamines due to renal insufficiency or by the rupture of a pancreatic pseudocyst in the peritoneum. This is this late mechanism that we report in this case of bisalbuminemia related to an opened pancreatic pseudocyst secondary to an adenoma of the parathyroid gland.
Subject(s)
Hyperparathyroidism/complications , Pancreatic Fistula/etiology , Pancreatic Pseudocyst/complications , Serum Albumin/analysis , Blood Protein Electrophoresis , Chronic Disease , Fistula/etiology , Humans , Hyperparathyroidism/blood , Male , Middle Aged , Pancreatic Fistula/blood , Pancreatic Pseudocyst/blood , Pancreatitis/etiology , Peritoneal Diseases/etiologySubject(s)
Autoantibodies/immunology , Autoantigens/immunology , Fetal Heart/immunology , Heart Block/congenital , Heart Defects, Congenital/embryology , RNA, Small Cytoplasmic , Ribonucleoproteins/immunology , Female , Fetal Heart/pathology , Heart Block/immunology , Heart Conduction System/abnormalities , Heart Conduction System/embryology , Heart Conduction System/immunology , Heart Defects, Congenital/immunology , Humans , Pregnancy , SS-B AntigenSubject(s)
Tuberculosis, Pulmonary/complications , Uveitis, Anterior/etiology , Adult , Female , HumansSubject(s)
Brachial Plexus Neuritis/etiology , Abdomen , Aged , Brachial Plexus Neuritis/diagnosis , Humans , MaleABSTRACT
BCG has been disappointing as immunotherapy of numerous cancers, but it has been clinically successful in the intravesical treatment of bladder carcinomas sparing the muscle coat; it has indeed become the reference treatment for this type of cancer. However, complications are repeatedly reported, including generalized BCGitis. We report such a case with positive BCG culture. From the cases already published there emerges a homogeneous and often subacute clinical presentation suggestive of an ordinary pathogen. Bacteriology is not very helpful, even when recent techniques are used, and therefore the diagnosis rests on the context and, when samples are taken, on suggestive histological findings. To discuss the physiopathology of BCGitis--generalized immune reaction or multifocal BCG proliferation--is not useless since treatment depends on it. It is probable that these 2 mechanisms working together can be incriminated justifying the prescription of both antibiotics and corticosteroids. When this is done, the prognosis seems to be favourable in most patients. Yet a strict respect of contra-indications and a very careful subsequent radiotherapy should reduce the risks.
Subject(s)
BCG Vaccine/adverse effects , Mycobacterium Infections/etiology , Mycobacterium bovis/isolation & purification , Papilloma/drug therapy , Urinary Bladder Neoplasms/drug therapy , Administration, Intravesical , Aged , Anti-Bacterial Agents , BCG Vaccine/administration & dosage , BCG Vaccine/therapeutic use , Drug Therapy, Combination/therapeutic use , Hepatomegaly/etiology , Herpes Zoster/etiology , Humans , Male , Mycobacterium Infections/drug therapy , Mycobacterium Infections/microbiologyABSTRACT
The antiphospholipid syndrome is usually defined by the association of a clinical manifestation (recurrent venous and/or arterial thrombosis, recurrent spontaneous miscarriages) and a biological abnormality (anticardiolipin antibody, lupus anticoagulant). We retrospectively analyzed the records of 5 patients (4 females, 1 male, aged 30 +/- 12 years) with antiphospholipid syndrome, primary (n = 1) or secondary to systemic lupus erythematosus (n = 4), who developed malignant systemic hypertension with renal insufficiency, in the absence of lupus nephritis. Before the episode of malignant hypertension, all patients had normal systemic blood pressure and renal function. During malignant hypertension the systolic pressure was 206 +/- 39 mmHg and the diastolic pressure 130 +/- 25 mmHg, peak serum creatinine was 204 +/- 95 mumol/l, daily proteinuria was 1.1 +/- 0.8 gr, and complement serum levels were normal in all patients. Renal angiography found normal proximal renal arteries. Renal biopsy showed ischaemic glomeruli without proliferative lesions (n = 5), focal intimal fibrosis either isolated (n = 3) or associated with thrombosis (n = 2) of the intrarenal vessels, and the absence of vasculitis. Immunofluorescence study did not reveal typical lupus deposits. Patients were treated with antihypertensive agents, increasing doses of prednisone (n = 3), and anticoagulant (n = 2) or anti-aggregant therapy (n = 1). After a mean follow-up of 6.8 +/- 5.2 years, 4 patients were still alive with normal blood pressure and renal function, whereas 1 patient died of a probable catastrophic antiphospholipid syndrome. Patients with antiphospholipid syndrome, primary or secondary to systemic lupus erythematosus, may develop malignant hypertension with renal insufficiency and intrarenal vascular lesions, in the absence of lupus nephritis.
Subject(s)
Antiphospholipid Syndrome/complications , Hypertension, Malignant/complications , Adolescent , Adult , Antiphospholipid Syndrome/etiology , Antiphospholipid Syndrome/pathology , Female , Humans , Hypertension, Malignant/etiology , Hypertension, Malignant/pathology , Kidney/pathology , Lupus Erythematosus, Systemic/complications , Lupus Erythematosus, Systemic/pathology , Lupus Nephritis/complications , MaleABSTRACT
A false left ventricular aneurysm and coronary artery aneurysm were discovered in a 29 year old patient with Behçet's syndrome. The operation under cardiopulmonary bypass consisted of closing the neck of the false aneurysm by an endo-aneurysmal approach with a Gore-Tex patch. The coronary artery aneurysms were respected. There were no postoperative complications. Cardiac involvement is rare in Behçet's syndrome (6%). The originality of this case is the association of two aneurysmal pathologies: the coronary and ventricular aneurysms due to the angiitis and the myocardial fragility induced by ischaemia.
Subject(s)
Behcet Syndrome/complications , Coronary Aneurysm/etiology , Heart Aneurysm/etiology , Adult , Coronary Aneurysm/diagnosis , Coronary Angiography , Heart Aneurysm/diagnosis , Heart Failure/etiology , Heart Ventricles , Humans , Male , Myocardial Infarction/etiology , Tomography, X-Ray ComputedABSTRACT
We report two cases of polychondritis associated with mesenteric panniculitis. Case 1. In February 1989, a woman born in 1949 presented with 40 degrees C fever accompanied by pain in the abdomen and pelvis. Eight days later, nodular skin lesions appeared on her lower limbs. The abdomen was swollen with gas and undepressible. An abdominal CT scan revealed partitioned peritoneal collections, and a guided needle aspiration produced a chylous fluid. Direct and indirect bacteriological examinations gave negative results. Histology showed intense inflammatory reaction with giant cells and lipophages, thereby confirming the presence of mesenteric panniculitis. Six months later, the development of chondritic lesions on the nose and the helix of the ear clinched the diagnosis of polychondritis. The patient was put on corticosteroid therapy for a few months, and in January this year (1993) she is durably asymptomatic. Case 2. In October 1977, a woman born in 1937 presented with polychondritis with prolonged fever, inflammatory syndrome and chondritic lesions of the nose, larynx and helix of the ear. In December 1978, she developed signs of abdominal obstruction. Laparotomy revealed infiltration by multiple nodular formations of the entire posterior line of attachment of the mesentery. Biopsies withdrew a puriform fluid. Histology showed a partly necrotic adipose tissue with giant cells and lipophages. High-dose corticosteroid therapy partially controlled the chondritic and abdominal manifestations. The occurrence of abdominal pain in patients with polychondritis may result from several disorders, such as iatrogenic complications, digestive tract vasculitis or ulcerative colitis, but also associated mesenteric panniculitis.
Subject(s)
Panniculitis, Peritoneal/etiology , Polychondritis, Relapsing/complications , Abdomen, Acute/etiology , Adult , Female , Humans , Middle Aged , Panniculitis, Peritoneal/diagnosisSubject(s)
Colostomy , Diverticulum, Colon/complications , Pyoderma/etiology , Skin Ulcer/etiology , Aged , Aged, 80 and over , Diverticulum, Colon/surgery , Female , HumansABSTRACT
During a mean therapeutic follow-up of 4 years, 25 out of 61 patients with Wegener's granulomatosis had one or several relapses. As in 7 of them the initial diagnosis had proved erroneous, this study concerns the remaining 18 patients who together totalled 31 relapses after the correct diagnosis was made. Twenty relapses occurred early on, within 4 months of a change in treatment, and they corresponded to recurrent activity of the disease. Ten relapses occurred later on, after treatment had been discontinued or kept at maintenance dose level. The relapses appeared as early as the first year in 41 percent of the cases. The ENT region was affected in 61 percent of the patients. Nine relapses occurred in the absence of treatment, including 6 which took place 1 to 8 years after treatment. Three relapses occurred less than 3 months after a prednisone and oral cyclophosphamide therapy was initiated. Compared with the group of patients without relapse, those in the relapse group were younger, more often treated with azathioprine and cyclophosphamide administered intravenously, and followed up for a longer period; their probability of survival was also higher. In case of early relapse after withdrawal of treatment the mean duration of that treatment had been shorter than in the absence of relapse. None of the patients whose treatment had been stopped more than 20 months after its onset had an early relapse. These data prompted us to make the following proposals: initially, cyclophosphamide should be administered as bolus injections (the time required to obtain results is then shorter than with the oral route), and maintenance therapy should last at least 20 months. Azathioprine should be used only when cyclophosphamide is contra-indicated. The relative indications for intravenous and oral cyclophosphamide remain to be determined. Discontinuing all treatments is a difficult decision to make, but even then the patients should be under close supervision in view of the possibility of late relapses.