Serum S100ß Levels Are Linked with Cognitive Decline and Peripheral Inflammation in Spinocerebellar Ataxia Type 2.

Experimental and clinical studies have indicated a potential role of the protein S100ß in the pathogenesis and phenotype of neurodegenerative diseases. However, its impact on spinocerebellar ataxia type 2 (SCA2) remains to be elucidated. The objective of the study is to determine the serum levels of S100ß in SCA2 and its relationship with molecular, clinical, cognitive, and peripheral inflammatory markers of the disease. Serum concentrations of S100ß were measured by enzyme-linked immunosorbent assay in 39 SCA2 subjects and 36 age- and gender-matched controls. Clinical scores of ataxia, non-ataxia symptoms, cognitive dysfunction, and some blood cell count-derived inflammatory indices were assessed. The SCA2 individuals manifested S100ß levels similar to the control group, at low nanomolar concentrations. However, the S100ß levels were directly associated with a better performance of cognitive evaluation within the SCA2 cohort. Moreover, the S100ß levels were inversely correlated with most peripheral inflammatory indices. Indeed, the neutrophil-to-lymphocyte ratio significantly mediated the effect of serum S100ß on cognitive performance, even after controlling for the ataxia severity in the causal mediation analysis. Our findings suggested that, within physiologic concentrations, the protein S100ß exerts a neuroprotective role against cognitive dysfunction in SCA2, likely via the suppression of pro-inflammatory mechanisms.

Reports of Recovered Memories in Therapy in Undergraduate Students.

Psychologists have debated the wisdom of recovering traumatic memories in therapy that were previously unknown to the client, with some concerns over accuracy and memory distortions. The current study surveyed a sample of 576 undergraduates in the south of the United States. Of 188 who reported attending therapy or counselling, 8% reported coming to remember memories of abuse, without any prior recollection of that abuse before therapy. Of those who reported recovered memories, 60% cut off contact with some of their family. Within those who received therapy, those who had a therapist discuss the possibility of repressed memory were 28.6 times more likely to report recovered memories, compared to those who received therapy without such discussion. These findings mirror a previous survey of US adults and suggest attempts to recover repressed memories in therapy may continue in the forthcoming generation of adults.

Memory experts' beliefs about repressed memory.

ABSTRACTWhat we believe about how memory works affects the decisions we make in many aspects of life. In Patihis, Ho et al. [Patihis, L., Ho, L. Y., Tingen, I. W., Lilienfeld, S. O., & Loftus, E. F. (2014). Are the "memory wars" over? A scientist-practitioner gap in beliefs about repressed memory. Psychological Science, 25, 519-530.], we documented several group's beliefs on repressed memories and other aspects of how memory works. Here, we present previously unreported data on the beliefs of perhaps the most credible minority in our dataset: memory experts. We provide the statistics and written responses of the beliefs for 17 memory experts. Although memory experts held similarly sceptical beliefs about repressed memory as other research-focused groups, they were significantly more sceptical about repressed memory compared to practitioners, students and the public. Although a minority of memory experts wrote that they maintained an open mind about repressed memories - citing research such as retrieval inhibition - all of the memory experts emphasised the dangers of memory distortion.

Black American College Students Report Higher Memory of Love for Mothers in Childhood Than White Students.

Cultural differences between Black and White individuals in the South are connected to the inequitable history of the United States. We wondered if these cultural differences would translate to a particularly precious aspect of life: memories of love felt in childhood toward one's parents. Some past studies have shown that Whites score higher on parental attachment measures to parents than Blacks, while other studies show no significant differences. However, no previous study has ever measured memory of feelings of love in relation to differences between ethnicities. In this study, Black (n = 124) and White (n = 125) undergraduates self-reported the strength and frequency of their past feelings of love toward their mother and father in first, sixth, and ninth grade as well as their current feelings of love. Results suggested that Black students reported feeling more love for their mothers in first, sixth, and ninth grades compared to White students. These findings were not explained when we statistically adjusted for age, gender, socioeconomic status, education levels, income, number of years spent living with mother or father, stress, or personality. Therefore, this relationship may be explained by unmeasured or unmeasurable cultural differences. The direction of this effect was in the opposite direction from what we expected based on past attachment research. Given the inequities in U.S. history and the current discussions around ethnicity and race in the United States, the finding that Blacks reported higher remembered feelings of love for their mothers in childhood is intriguing and worthy of dissemination and discussion.