ABSTRACT
Los trastornos del espectro autista (TEA) consisten en una diada caracterizada por deficiencias en la comunicación e interacción social y patrones restrictivos y repetitivos de comportamiento. En conjunto tienen una prevalencia del 0,6% en la población general, aunque no se cuenta con estadísticas nacionales. Si bien la evolución es variable, se ha visto que la intervención temprana es un factor importante en la determinación del pronóstico. El objetivo del presente trabajo ha sido actualizar conceptos respecto a la evidencia actual disponible sobre la relevancia de intervenir tempranamente este tipo de trastornos. Con el análisis de la información recopilada se confirma la importancia de la intervención temprana en niños con TEA, como así también, el rol de pediatras y otros profesionales de la salud en la detección precoz de estos trastornos.
Autism Spectrum Disorders (ASD) are characterized by impairments in communication and social interaction, as well as restricted and repetitive patterns of behavior. They have a prevalence of 0.6% in the general population, although there are no national statistics. Even though their evolution is variable, it has been observed that early intervention is an important factor determining prognosis. The aim of this study is to update concepts regarding the current available evidence on the importance of early intervention. After analyzing the collected information, the importance of early intervention programs for children with ASD is confirmed, as well as the role of pediatricians and other health professionals in the early detection of these disorders.
Subject(s)
Humans , Child , Autism Spectrum Disorder/therapy , Prognosis , Early Diagnosis , Autism Spectrum Disorder/diagnosis , Autism Spectrum Disorder/physiopathologyABSTRACT
Background: Low molecular weight hepartin can be administered by the subcutaneous route and has stable and prolonged antithrombotic effect. These features have prompted clinical essays about its use as an alternative to unfractional heparin in the treatmen of unstable angina. Aim: To compare the clinical effects of low molecular weight heparin and unfractionated conventional heparin in patients with unstable angina or non Q infarction. Patients and methods: Seventy patients (47 male) admitted to the hospital with the diagnosis of unstable angina or non Q acute myocardial infarction were randomly assigned to receive unfractionated intravenous heparin or subcutaneous low molecular weight heparin bid. All received aspirin po and iv nitroglycerin. The incidence of recurrent angina, acute myocardial infarction or a need for emergency surgical revascularization during hospital stay were assessed in both groups. Results: Compared to patients with low molecular weight heparin, patients receiving unfractionated heparin had a higher incidence of recurrent resting angina (23 and 47.75 percent respectively, p< 0.04) and higher need for emergency surgical revascularization (3.3 and 17.5 percent respectively, p< 0.06). Patients treated with unfractionated conventional heparin had a 3 times higher risk of having an adverse cardiovascular event than patients receiving low molecular weight heparin (O.R. 0.33, confidence intervals 0.11-0.58). Conclusions: Low molecular weight heparin is superior to unfractionated conventional heparin in the treatment of unstable angina and non Q acute myocardial infarction
