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1.
Article in English | MEDLINE | ID: mdl-32522350

ABSTRACT

We examined possible early-effect biomarkers and polymorphisms of susceptibility in primary school children living near the Atoyac River in central México, which receives waste from multiple industries. We observed a significant increase in micronucleated reticulocytes associated with the oxidative stress index (OSI) and the OGG1 GG (S326C) genotype, and a significant decrease of reticulocytes carrying the transferrin receptor, inversely correlated with OSI.


Subject(s)
DNA Glycosylases/genetics , Environmental Pollution/adverse effects , Oxidative Stress/drug effects , Polymorphism, Genetic/drug effects , Reticulocytes/drug effects , Adolescent , Biomarkers/metabolism , Child , Female , Genotype , Humans , Male , Micronucleus Tests/methods
2.
Environ Mol Mutagen ; 59(7): 639-652, 2018 08.
Article in English | MEDLINE | ID: mdl-29968258

ABSTRACT

Although the Atoyac River has been classified as highly polluted by environmental authorities, several communities are settled on its banks, affecting around 1.5 million persons, as well as farmland, due to an environmental distribution of toxics in the area. Our aim was to demonstrate that this environment affects important physiological processes that have an impact in health, so we conducted a study of schoolchildren from small communities on the banks of the river and in another similar town located far from it. 91 and 93 students, boys and girls, were studied from each site for oxidative stress index (OSI), calculated from the total antioxidant capacity and the total oxidative status, BTEX metabolite excretion and relevant metabolic polymorphisms participating in the bioactivation-detoxification of most VOC: CYP2E1 RsaI, NQO1 C609T, and null polymorphisms of GSTT1 and GSTM1. Results showed that OSI was significantly higher in children living by the river (5.23 ± 3.4 vs 2.59 ± 1.46, 95% C.I.). At this site, OSI was correlated with diminished metabolite excretion and a diminished antioxidant capacity; an association with genotypes CYP2E1RsaI (c2c2), GSTT1 present and NQO1*2 (CC) was also observed. Furthermore, boys at this site exhibited a diminished BMI compared to boys from the other community who were younger. IN CONCLUSION: children living at polluted sites like this, show early biological effects that might lead to health problems in their adult life. Environmental protection should be enforced to protect people's health in these sites where not even environmental monitoring is done. Environ. Mol. Mutagen. 59:639-652, 2018. © 2018 Wiley Periodicals, Inc.


Subject(s)
Environmental Exposure/adverse effects , Industrial Waste/adverse effects , Oxidative Stress/drug effects , Volatile Organic Compounds/metabolism , Volatile Organic Compounds/urine , Water Pollutants/metabolism , Water Pollutants/urine , Adolescent , Child , Female , Genotype , Glutathione Transferase/genetics , Glutathione Transferase/metabolism , Humans , Inactivation, Metabolic , Industrial Waste/analysis , Male , Mexico , Polymorphism, Genetic , Rivers/chemistry , Volatile Organic Compounds/adverse effects , Volatile Organic Compounds/analysis , Water Pollutants/adverse effects , Water Pollutants/analysis
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