Mecanismos moleculares de reparación mediante la técnica Electrólisis Percutánea Intratisular en la tendinosis rotuliana / Molecular repair mechanisms using the Intratissue Percutaneous Electrolysis technique in patellar tendonitis

Objetivo. Investigar los mecanismos moleculares de respuesta tisular tras el tratamiento con la técnica Electrólisis Percutánea Intratisular (EPI®) en la tendinosis inducida por colagenasa tipo i en ratas Sprague Dawley. Métodos. En una muestra de 24 ratas Sprague Dawley de 7 meses de edad y 300 g se indujo tendinosis mediante la inyección en el tendón rotuliano de 50 μg de colagenasa tipo i . Se procedió a dividir la muestra en 4 grupos: un grupo control, un grupo colagenasa y 2 grupos de tratamiento con técnica EPI® a 3 y 6 mA, respectivamente. Se aplicó una sesión de tratamiento EPI® y tras 3 días se procedió al análisis de los tendones mediante técnicas de inmunodetección y electroforesis. Se analizaron las proteínas citocromo C, Smac/Diablo, factor de crecimiento endotelial vascular y su receptor 2. También se analizó el factor de transcripción nuclear peroxisoma proliferador activado del receptor gamma. Resultados. Se observó un aumento estadísticamente significativo en la expresión del citocromo C, Smac/Diablo, factor de crecimiento endotelial vascular, su receptor 2 y peroxisoma proliferador activado del receptor gamma en los grupos a los que se les aplicó la técnica EPI® respecto al grupo control. Conclusiones. La técnica EPI® produce, en la lesión tendinosa inducida con colagenasa tipo i en ratas, un aumento de los mecanismos moleculares antiinflamatorios y angiogénicos (AU)

Objective. To investigate the molecular mechanisms of tissue response after treatment with the Intratissue Percutaneous Electrolysis (EPI®) technique in collagenase-induced tendinopathy in Sprague-Dawley rats. Methods. Tendinopathy was induced by injecting 50 μg of type i collagenase into the patellar tendon of 24 Sprague Dawley rats of 7 months of age and weighting 300 g. The sample was divided into 4 groups: the control group, collagenase group, and two EPI® technique treatment groups of 3 and 6 mA, respectively. An EPI® treatment session was applied, and after 3 days, the tendons were analysed using immunoblotting and electrophoresis techniques. An analysis was also made of cytochrome C protein, Smac/Diablo, vascular endothelial growth factor and its receptor 2, as well as the nuclear transcription factor peroxisome proliferator-activated receptor gamma. Results. A statistically significant increase, compared to the control group, was observed in the expression of cytochrome C, Smac/Diablo, vascular endothelial growth factor, its receptor 2 and peroxisome proliferator-activated receptor gamma in the groups in which the EPI® technique was applied. Conclusions. EPI® technique produces an increase in anti-inflammatory and angiogenic molecular mechanisms in collagenase-induced tendon injury in rats (AU)

[Molecular repair mechanisms using the Intratissue Percutaneous Electrolysis technique in patellar tendonitis]. / Mecanismos moleculares de reparación mediante la técnica Electrólisis Percutánea Intratisular en la tendinosis rotuliana.

OBJECTIVE: To investigate the molecular mechanisms of tissue response after treatment with the Intratissue Percutaneous Electrolysis (EPI(®)) technique in collagenase-induced tendinopathy in Sprague-Dawley rats. METHODS: Tendinopathy was induced by injecting 50 µg of type i collagenase into the patellar tendon of 24 Sprague Dawley rats of 7 months of age and weighting 300 g. The sample was divided into 4 groups: the control group, collagenase group, and two EPI(®) technique treatment groups of 3 and 6 mA, respectively. An EPI(®) treatment session was applied, and after 3 days, the tendons were analysed using immunoblotting and electrophoresis techniques. An analysis was also made of cytochrome C protein, Smac/Diablo, vascular endothelial growth factor and its receptor 2, as well as the nuclear transcription factor peroxisome proliferator-activated receptor gamma. RESULTS: A statistically significant increase, compared to the control group, was observed in the expression of cytochrome C, Smac/Diablo, vascular endothelial growth factor, its receptor 2 and peroxisome proliferator-activated receptor gamma in the groups in which the EPI(®) technique was applied. CONCLUSIONS: EPI(®) technique produces an increase in anti-inflammatory and angiogenic molecular mechanisms in collagenase-induced tendon injury in rats.

[Psycho-pathological risk factor of arterial disease (prevalence, superposition or vinculation with other factors)]. / Estudio oncativo: factores de riesgo psicopatológicos de enfermedad arterial (prevalencia, superposición o vínculo con otros factores).

Alexitimia and depression may or not coexist with others risk factors (comportment o physical). Frecuently they have relation with socio-echonomic status and with ethnia. Sometimes are determinants of the atherosclerotic process by increasing the vascular reactivity by the alteration of the evolution. There is no information in our country about this problem in general population. The present study result of the investigation of these aspects and the comportamental and physical factors of arterial disease, in a population of Cordoba province (Argentina Republic).

Estudio oncativo: factores de riesgo psicopatológicos de enfermedad arterial (prevalencia, superposición o vínculo con otros factores) / Psycho-pathological risk factor of arterial disease (prevalence, superposition or vinculation with other factors)

Entidades psicopatológicas como alexitimia y depresión, pueden coexistir o no con factores de riesgo de enfermedad arterial o ser entidades independientes. Tienen frecuentemente relación con aspectos socio-económico-culturales y con la etnia; a veces son determinantes del proceso ateroesclerótico por alterar la reactividad vascular (Alexitimai) o agravadores del proceso evolutivo (depresión). Materiales y métodos: Existe escasa información sobre esta tematica en nuestro país: la existente se refiere a los mismos en muestras seleccionadas, no de poblaciones generales (urbanas o rurales). Resultados: se exponen los resultados obtenidos de lainvestigación de esos factores en una población de la Provincia de Córdoba (RA), donde simultáneamente se estudiaron factores de orden fisico y conductual. Conclusiones: La prevalencia de la depresión es más elevada que en otras poblaciones

Alexitimia and depression may or not coexist with others risk factors (comportment o physical). Frecuently they have relation with socio-echonomic status and with ethnia. Sometimes are determinants of the atherosclerotic process by increasing the vascular reactivity by the alteration of the evolution. There is no information in our country about this problem in general population. The present study result of the investigation of these aspects and the comportamental and physical factors of arterial disease, in a population of Cordoba province (Argentina Republic).

[Medical-psychological consultation at San Roque hospital]. / Interconsulta médico-psicológica en el Hospital San Roque.

This paper has been done to comunicate a conception of Interconsultation (Liaison) developed in the Metal Health Service from San Roque Hospital. It begins with a general review around theoretical and technical evolution about Interconsultation in a general Hospital. Then it describes our theoretical point of view and its instrumentation, with especial enphasis in the idea of "to include the human being of our sick subject". The article affirms the necessity of thransferencial relantionship among Interconsultator and Interconsultant. All process is representated by diagrams. In them, we can see the identification of problems, the strategies and tactics that determine courses of action, and how to evaluate these procedures.

Interconsulta médico-psicológica en el Hospital San Roque / [Medical-psychological consultation at San Roque hospital]

This paper has been done to comunicate a conception of Interconsultation (Liaison) developed in the Metal Health Service from San Roque Hospital. It begins with a general review around theoretical and technical evolution about Interconsultation in a general Hospital. Then it describes our theoretical point of view and its instrumentation, with especial enphasis in the idea of [quot ]to include the human being of our sick subject[quot ]. The article affirms the necessity of thransferencial relantionship among Interconsultator and Interconsultant. All process is representated by diagrams. In them, we can see the identification of problems, the strategies and tactics that determine courses of action, and how to evaluate these procedures.

Interconsulta médico-psicológica en el Hospital San Roque. / [Medical-psychological consultation at San Roque hospital]

This paper has been done to comunicate a conception of Interconsultation (Liaison) developed in the Metal Health Service from San Roque Hospital. It begins with a general review around theoretical and technical evolution about Interconsultation in a general Hospital. Then it describes our theoretical point of view and its instrumentation, with especial enphasis in the idea of [quot ]to include the human being of our sick subject[quot ]. The article affirms the necessity of thransferencial relantionship among Interconsultator and Interconsultant. All process is representated by diagrams. In them, we can see the identification of problems, the strategies and tactics that determine courses of action, and how to evaluate these procedures.