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1.
Emerg Infect Dis ; 22(5): 780-5, 2016 May.
Article in English | MEDLINE | ID: mdl-27089251

ABSTRACT

In the United States, all previously reported cases of Rickettsia parkeri rickettsiosis have been linked to transmission by the Gulf Coast tick (Amblyomma maculatum). Here we describe 1 confirmed and 1 probable case of R. parkeri rickettsiosis acquired in a mountainous region of southern Arizona, well beyond the recognized geographic range of A. maculatum ticks. The likely vector for these 2 infections was identified as the Amblyomma triste tick, a Neotropical species only recently recognized in the United States. Identification of R. parkeri rickettsiosis in southern Arizona demonstrates a need for local ecologic and epidemiologic assessments to better understand geographic distribution and define public health risk. Education and outreach aimed at persons recreating or working in this region of southern Arizona would improve awareness and promote prevention of tickborne rickettsioses.


Subject(s)
Rickettsia Infections/microbiology , Rickettsia , Adult , Animals , Arizona/epidemiology , Female , Genes, Bacterial , Humans , Male , Middle Aged , Rickettsia/classification , Rickettsia/genetics , Rickettsia Infections/diagnosis , Rickettsia Infections/epidemiology , Rickettsia Infections/transmission , Sequence Analysis, DNA , Tick Bites , Tick-Borne Diseases/diagnosis , Tick-Borne Diseases/microbiology , Tick-Borne Diseases/transmission , Ticks/microbiology
2.
Proc Natl Acad Sci U S A ; 102(37): 13206-11, 2005 Sep 13.
Article in English | MEDLINE | ID: mdl-16141333

ABSTRACT

Nearly finished sequences for model organisms provide a foundation from which to explore genomic diversity among other taxonomic groups. We explore genome-wide microsynteny patterns between the rice sequence and two sorghum physical maps that integrate genetic markers, bacterial artificial chromosome (BAC) fingerprints, and BAC hybridization data. The sorghum maps largely tile a genomic component containing 41% of BACs but 80% of single-copy genes that shows conserved microsynteny with rice and partially tile a nonsyntenic component containing 46% of BACs but only 13% of single-copy genes. The remaining BACs are centromeric (4%) or unassigned (8%). The two genomic components correspond to cytologically discernible "euchromatin" and "heterochromatin." Gene and repetitive DNA distributions support this classification. Greater microcolinearity in recombinogenic (euchromatic) than nonrecombinogenic (heterochromatic) regions is consistent with the hypothesis that genomic rearrangements are usually deleterious, thus more likely to persist in nonrecombinogenic regions by virtue of Muller's ratchet. Interchromosomal centromeric rearrangements may have fostered diploidization of a polyploid cereal progenitor. Model plant sequences better guide studies of related genomes in recombinogenic than nonrecombinogenic regions. Bridging of 35 physical gaps in the rice sequence by sorghum BAC contigs illustrates reciprocal benefits of comparative approaches that extend at least across the cereals and perhaps beyond.


Subject(s)
Chromosome Structures , Physical Chromosome Mapping/methods , Poaceae/genetics , Recombination, Genetic , Synteny , Base Sequence , Euchromatin , Genome, Plant , Heterochromatin , Molecular Sequence Data , Oryza/genetics , Sorghum/genetics
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