ABSTRACT
Azabicyclo[2.1.1]hexanes (aza-BCHs) and bicyclo[1.1.1]pentanes (BCPs) have emerged as attractive classes of sp3-rich cores for replacing flat, aromatic groups with metabolically resistant, three-dimensional frameworks in drug scaffolds. Strategies to directly convert, or "scaffold hop", between these bioisosteric subclasses through single-atom skeletal editing would enable efficient interpolation within this valuable chemical space. Herein, we describe a strategy to "scaffold hop" between aza-BCH and BCP cores through a nitrogen-deleting skeletal edit. Photochemical [2+2] cycloadditions, used to prepare multifunctionalized aza-BCH frameworks, are coupled with a subsequent deamination step to afford bridge-functionalized BCPs, for which few synthetic solutions currently exist. The modular sequence provides access to various privileged bridged bicycles of pharmaceutical relevance.
ABSTRACT
We describe practical methods to prepare DOTAGA-DBCO and DFO-DBCO from commercially available starting materials. DOTAGA-DBCO is available in five steps from cyclen with a 33 % overall yield at gram scale. Our synthesis of DFO-DBCO also proceeds in five steps from commercially available starting materials. These bifunctional molecules possess chelating functionality for the binding of medically important radiometals and a strained alkyne suitable for Huisgen cyclization with an azide. These syntheses represent an important step toward improved radioimmunoconjugates for imaging and therapeutic applications.
Subject(s)
Cyclams , Immunoconjugates , Alkynes/chemistry , Azides/chemistry , Cyclization , Immunoconjugates/pharmacology , Immunoconjugates/therapeutic useABSTRACT
Herein a method for the radical alkylation of heteroaryl halides that relies upon the combination of photoredox and nickel catalysis is described. The use of aliphatic N-(acyloxy)phthalimides as redox-active esters affords primary and secondary radicals for the decarboxylative dual cross-coupling with pyrimidine and pyridine heteroaryl chlorides, bromides, and iodides. The method provides an additional synthetic tool for the incorporation of medicinally relevant heterocyclic motifs.
Subject(s)
Esters , Nickel , Alkylation , Molecular Structure , Oxidation-Reduction , Photochemical ProcessesABSTRACT
An asymmetric total synthesis of (+)-6-hydroxythiobinupharidine (1b) and (-)-6-hydroxythionuphlutine (2b), a set of hemiaminal containing dimeric sesquiterpenes isolated from yellow water lilies of the Nuphar genus, is described. The central bis-spirocyclic tetrahydrothiophene ring was forged through the Stevens rearrangement of a sulfonium ylide, generated in situ from the coupling of a copper-carbene with a spirocyclic thietane. This strategy diverges both from the proposed biosynthesis1 and previous syntheses of this family of alkaloids,2,3 all of which employ dimerization of symmetric monomers to form the aforementioned thiaspirane. The coupling of unsymmetrical monomers allowed access to the unsymmetrically oxidized product 2b for the first time.
Subject(s)
Alkaloids/chemistry , Copper/chemistry , Nuphar/chemistry , Sesquiterpenes/chemical synthesis , Catalysis , Oxidation-Reduction , Sesquiterpenes/chemistry , Sesquiterpenes/isolation & purificationABSTRACT
The use of copper in directed C-H oxidation has been relatively underexplored. In a seminal example, Schönecker showed that copper and O2 promoted the hydroxylation of steroid-containing ligands. Recently, Baran (J. Am. Chem. Soc. 2015, 137, 13776) improved the reaction conditions to oxidize similar substrates with excellent yields. In both reports, the involvement of Cu2O2 intermediates was suggested. In this collaborative article, we studied the hydroxylation mechanism in great detail, resulting in the overhaul of the previously accepted mechanism and the development of improved reaction conditions. Extensive experimental evidence (spectroscopic characterization, kinetic analysis, intermolecular reactivity, and radical trap experiments) is provided to support each of the elementary steps proposed and the hypothesis that a key mononuclear LCuII(OOR) intermediate undergoes homolytic O-O cleavage to generate reactive RO⢠species, which are responsible for key C-H hydroxylation within the solvent cage. These key findings allowed the oxidation protocol to be reformulated, leading to improvements of the reaction cost, practicability, and isolated yield.
Subject(s)
Copper/chemistry , Oxides/chemistry , Steroids/chemical synthesis , Hydroxylation , Ligands , Models, Molecular , Molecular Structure , Oxidation-Reduction , Oxygen/chemistry , Steroids/chemistryABSTRACT
Steroids bearing C12 oxidations are widespread in nature, yet only one preparative chemical method addresses this challenge in a low-yielding and not fully understood fashion: Schönecker's Cu-mediated oxidation. This work shines new light onto this powerful C-H oxidation method through mechanistic investigation, optimization, and wider application. Culminating in a scalable, rapid, high-yielding, and operationally simple protocol, this procedure is applied to the first synthesis of several parent polyoxypregnane natural products, representing a gateway to over 100 family members.
Subject(s)
Copper/chemistry , Polymers/chemical synthesis , Pregnanes/chemical synthesis , Models, Molecular , Molecular Conformation , Oxidation-Reduction , Polymers/chemistry , Pregnanes/chemistryABSTRACT
A stereodivergent approach to the central thiolane subunit of Nuphar sesquiterpene thioalkaloids has been developed. This approach features a rhodium-catalyzed Stevens-type rearrangement in conjunction with an enzyme resolution reaction. Further elaboration into a polycyclic ring system via alcohol oxidation and ring-closing metathesis is also described.
Subject(s)
Alkaloids/chemical synthesis , Nuphar/chemistry , Sesquiterpenes/chemical synthesis , Sulfhydryl Compounds/chemical synthesis , Alkaloids/chemistry , Catalysis , Oxidation-Reduction , Rhodium/chemistry , Sesquiterpenes/chemistry , Structure-Activity Relationship , Sulfhydryl Compounds/chemistryABSTRACT
A direct α-fluorination of N-acyloxazolidinones based on the unique reactivity of group IVa metal enolates has been developed. The reaction is an experimentally simple, low-cost, quick, and energy-efficient alternative for asymmetric α-fluorination of N-acyloxazolidinones. Preliminary studies have shown compatibility with alkyl, alkenyl, and alkynyl, aromatic, and several heteroaromatic substituents. High diastereoselectivities have been achieved with most substrates tested, and the reaction is typically complete within 1 h at ambient temperature.
Subject(s)
Alkenes/chemistry , Alkynes/chemistry , Oxazolidinones/chemistry , Catalysis , Halogenation , Molecular Structure , Stereoisomerism , TemperatureABSTRACT
A Ru-catalyzed direct thermal trifluoromethylation and perfluoroalkylation of N-acyloxazolidinones has been developed. The reaction is experimentally simple and requires inexpensive reagents while providing good yields of products with good levels of stereocontrol. Preliminary studies have shown notable compatibility with functional groups, aromatics, and certain heteroaromatic substituents. The described method provides a useful alternative for the synthesis of fluorinated materials in an experimentally convenient manner.
Subject(s)
Ketones/chemistry , Organometallic Compounds/chemistry , Oxazolidinones/chemical synthesis , Ruthenium/chemistry , Zirconium/chemistry , Catalysis , Free Radicals/chemistry , Methylation , Molecular Conformation , Oxazolidinones/chemistry , StereoisomerismABSTRACT
A new protecting-group-free synthesis of the marine monocyclic ether (+)-brevisamide is reported. The enantioselective synthesis utilizes a key asymmetric Henry reaction and an Achmatowicz rearrangement for the formation of the tetrahydropyran ring. A penultimate Stille cross-coupling allows for an efficient installation of the conjugated (E,E)-diene side chain ultimately delivering (+)-brevisamide.
Subject(s)
Alkaloids/chemical synthesis , Pyrans/chemical synthesis , Alkaloids/chemistry , Marine Biology , Molecular Structure , Pyrans/chemistry , StereoisomerismSubject(s)
Oxazolidinones/chemistry , Ruthenium/chemistry , Titanium/chemistry , Alkylation , Catalysis , IsomerismABSTRACT
A hydroxyl group-directed, highly regio- and stereoselective transposition of allylic alcohols based on rhenium catalysis has been developed. The method is suitable for a direct isomerization of acetals into the thermodynamically preferred isomer as long as one of the hydroxyl groups is allylic. This method will expand the scope of rhenium-catalyzed alcohol transpositions for complex molecule synthesis.