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Angew Chem Int Ed Engl
; 48(24): 4422-5, 2009.
Article
in English
| MEDLINE
| ID: mdl-19431172
ABSTRACT
Simplify, simplify, simplify! Pretubulysin (structure without the green substituents), a simplified tubulysin was prepared in the laboratory and also found in a natural myxobacterial source. This biosynthetic precursor of the tubulysins is not as active as tubulysins A and D but is still effective in picomolar concentrations against cancer cell lines.