Subject(s)
Embryo Disposition/ethics , Embryo Research/ethics , Embryonic Stem Cells , Guidelines as Topic , National Institutes of Health (U.S.) , Oocyte Donation , Tissue Donors , Cell Line , Disclosure , Embryo Disposition/standards , Female , Fertilization in Vitro , Humans , Informed Consent , United StatesABSTRACT
The use of iPSCs and tetraploid complementation for human reproductive cloning would raise profound ethical objections. Professional standards and laws that ban human reproductive cloning by somatic cell nuclear transfer should be revised to also forbid it by other methods, such as iPSCs via tetraploid complementation.
Subject(s)
Bioethics , Cloning, Organism/ethics , Pluripotent Stem Cells/cytology , Animals , Cell Differentiation , Cloning, Organism/methods , Guidelines as Topic , Humans , MiceABSTRACT
Stem cell researchers commonly use human pluripotent stem cell lines derived by other investigators. Researchers may use lines derived elsewhere, provided that their derivation met consensus core standards. Some types of derivation raise heightened levels of ethical concern and require greater scrutiny. To maintain public trust, research institutions need to justify why they allow researchers to use lines whose derivation would not have been permitted locally.
